ABSTRACT
A bimaxillary osteotomy for mandibular prognathism and maxillary retrognathia was performed on 30 patients with an Angle Class III malocclusion. The Luhr condylar positioning device was used intraoperatively to reproduce the condylar position. Pre- and postoperative condylar positions were compared by recording joint movements with axiography. Steps, jags and jumps as symptoms of pathological joint function could not be identified. Only in one case could a pathological shortening of the joint track length be measured. This suggests that the Luhr device is effective in securing condyle position and therefore temporomandibular joint (TMJ) function. Pre- and postoperative axiography is an adequate method of controlling these results and a helpful supplement to the armentarium of orthognathic surgery.
Subject(s)
Jaw Relation Record/instrumentation , Malocclusion, Angle Class III/surgery , Mandible/surgery , Mandibular Condyle/anatomy & histology , Maxilla/surgery , Dental Articulators , Dental Occlusion , Follow-Up Studies , Humans , Incisor/anatomy & histology , Intraoperative Care , Jaw Relation Record/methods , Mandibular Condyle/physiology , Maxilla/abnormalities , Movement , Osteotomy/methods , Prognathism/surgery , Range of Motion, Articular , Temporomandibular Joint/physiologyABSTRACT
In an in vitro trial on 80 pregnant and nonpregnant mice, the sensitivity of the uterus myometrium to the vasoconstrictors vasopressin, ornipressin, epinephrine, and norepinephrine was examined in comparison with oxytocin as a standardized stimulative drug. The pregnant uterus showed a significantly increased sensitivity to ornipressin, vasopressin, and norepinephrine. Epinephrine showed no uterus-stimulating effect, and an increase of sensitivity caused by pregnancy was not detected.
Subject(s)
Myometrium/drug effects , Pregnancy, Animal/physiology , Vasoconstrictor Agents/pharmacology , Animals , Drug Tolerance , Epinephrine/pharmacology , Female , Mice , Norepinephrine/pharmacology , Ornipressin/pharmacology , Pregnancy , Vasopressins/pharmacologyABSTRACT
Phosphocreatine (PCr) is a critical intracellular energy reservoir used in the regeneration of ATP. The aim of this study was to determine the efficacy of exogenously added PCr on preservation of renal function in an in vitro model. The renal artery and ureter of a rat were cannulated and the kidney was subjected to 45 min of normothermic in vivo ischemia. The kidneys were then perfused ex vivo with either a Krebs-bicarbonate solution (Krebs) or a Krebs solution containing 3 mM PCr or an osmotically balanced solution containing 3 mM PCr. Our results indicate that the perfusion of kidneys subjected to 45 min of warm ischemia with solutions containing PCr resulted in significant improvements in GFR, RPF, and V, FRNa and FRH2O compared to KREBS alone. This suggests that the important factor in preservation of kidney function after an initial ischemic insult may be the addition of PCr rather that the electrolyte solution used.
