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6.
Acta Biochim Pol ; 23(4): 285-91, 1976.
Article in English | MEDLINE | ID: mdl-1035019

ABSTRACT

In human erythrocytes and Ehrlich ascites tumour cells, NaF inhibites aerobic glucose utilization and lactate formation. The inhibition of glycolysis was accompanied by a decrease in cellular pyruvate and ATP, and by accumulation of 2-hosphoenolpyruvate. These results and direct enzymatic determinations showed that fluoride inhibits, in addition to enolase (phosphopyruvate hydratase, EC 4.2.1.11), also pyruvate kinase.


Subject(s)
Carcinoma, Ehrlich Tumor/metabolism , Erythrocytes/metabolism , Fluorides/pharmacology , Glycolysis/drug effects , Sodium Fluoride/pharmacology , Animals , Cell Line , Humans , Phosphopyruvate Hydratase/antagonists & inhibitors , Pyruvate Kinase/antagonists & inhibitors
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