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1.
Cognition ; 111(3): 364-71, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19375075

ABSTRACT

In some cases people judge it morally acceptable to sacrifice one person's life in order to save several other lives, while in other similar cases they make the opposite judgment. Researchers have identified two general factors that may explain this phenomenon at the stimulus level: (1) the agent's intention (i.e. whether the harmful event is intended as a means or merely foreseen as a side-effect) and (2) whether the agent harms the victim in a manner that is relatively "direct" or "personal". Here we integrate these two classes of findings. Two experiments examine a novel personalness/directness factor that we call personal force, present when the force that directly impacts the victim is generated by the agent's muscles (e.g., in pushing). Experiments 1a and b demonstrate the influence of personal force on moral judgment, distinguishing it from physical contact and spatial proximity. Experiments 2a and b demonstrate an interaction between personal force and intention, whereby the effect of personal force depends entirely on intention. These studies also introduce a method for controlling for people's real-world expectations in decisions involving potentially unrealistic hypothetical dilemmas.


Subject(s)
Retrospective Moral Judgment , Adult , Cognition/physiology , Crime Victims , Female , Generalization, Psychological , Humans , Male , Physical Stimulation
2.
Nucleic Acids Res ; 31(22): 6663-73, 2003 Nov 15.
Article in English | MEDLINE | ID: mdl-14602927

ABSTRACT

The DNA-binding protein Fis frequently uses pairs of sites 7 or 11 base pairs (bp) apart. Two overlapping Fis sites separated by 11 bp are found in the Escherichia coli origin of chromosomal replication. Only one of these sites is bound by Fis at a time, so the structure is a molecular flip-flop that could direct alternative firing of replication complexes in opposite directions. Alternatively, the flip-flop could represent part of an on-off switch for replication. Because they can be used to create precise switched states, molecular flip-flops could be used as the basis of a novel molecular computer.


Subject(s)
DNA-Binding Proteins/metabolism , Factor For Inversion Stimulation Protein/metabolism , Bacterial Proteins/metabolism , Base Sequence , Binding Sites/genetics , Binding, Competitive , DNA-Binding Proteins/chemistry , Dimerization , Electrophoretic Mobility Shift Assay , Escherichia coli/genetics , Factor For Inversion Stimulation Protein/chemistry , Models, Genetic , Models, Molecular , Molecular Sequence Data , Oligonucleotides/chemistry , Oligonucleotides/genetics , Oligonucleotides/metabolism , Protein Binding , Replication Origin/genetics , Sequence Homology, Nucleic Acid
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