Introduction: ECOC 2013 in London.

We introduce the Optics Express special issue from the 39th European Conference on Optical Communication and Exhibition (ECOC). This issue consists of expanded papers selected to represent the best presentations from the six subcommittees of ECOC 2013.

Nanomechanical optical fiber.

Optical fibers are an excellent transmission medium for light and underpin the infrastructure of the Internet, but generally after fabrication their optical properties cannot be easily modified. Here, we explore the concept of nanomechanical optical fibers where, in addition to the fiber transmission capability, the internal core structure of the fiber can also be controlled through sub-micron mechanical movements. The nanomechanical functionality of such fibers is demonstrated in the form of dual core optical fibers, in which the cores are independently suspended within the fiber. The movement-based optical change is large compared with traditional electro-optical effects and we show that optical switching of light from one core to the other is achieved through moving one core by just 8 nm.

Continuously tunable optical buffer with a dual silicon waveguide design.

We propose a design for an optical buffer that comprises two coupled silicon waveguides, which is capable of generating a large continuously tunable change in the propagation delay time. The optical delay can be varied by more than 100% through varying the spacing between the waveguides.

Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney.

CONTEXT: Clear cell sarcoma of the kidney (CCSK) is a prognostically unfavorable renal neoplasm of childhood. Previous cytogenetic studies of CCSK have reported balanced translocations t(10;17)(q22;p13) and t(10;17)(q11;p12). Although the tumor suppressor gene p53 is located at the chromosome 17p13 breakpoint, p53 abnormalities are rarely present in these tumors. OBJECTIVE: To identify cytogenetic abnormalities in CCSK and correlate these findings with other clinicopathologic parameters. DESIGN: A retrospective review of CCSK patients from 1990 to 2005 was conducted at our medical center. We performed clinical and histologic review, p53 immunohistochemical and classic cytogenetics (or ploidy analysis), and p53 fluorescence in situ hybridization analyses. RESULTS: Five male patients (age range, 6 months to 4 years) were identified with cytogenetic abnormalities. Of 3 cytogenetically informative cases, one revealed a clonal balanced translocation t(10;17)(q22;p13) and an interstitial deletion of chromosome 14, del(14)(q24.1q31.1), and the other 2 patients had normal karyotypes. Fluorescence in situ hybridization for p53 in the t(10;17) case revealed no deletion. Immunohistochemical evaluation of p53 demonstrated lack of nuclear protein accumulation in all cases. CONCLUSIONS: Together with the published literature, our results indicate that translocation (10;17) and interstitial deletions of chromosome 14q are recurring cytogenetic lesions in CCSK. To date, 3 cases of CCSK or "sarcomatoid Wilms tumors" have been reported to exhibit t(10;17). One previously reported case of CCSK contained deletion 14q. Results of p53 immunohistochemistry and/or p53 fluorescence in situ hybridization in this report suggest lack of mutations or deletions of this tumor suppressor in these CCSK cases. The t(10;17) breakpoint and deletion of chromosome 14q24 suggest that other genes are involved in tumor pathogenesis.