Isolation of two highly methylated polyketide derivatives from a yew-associated penicillium species

Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both compounds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.

Gloeolactone, a New Epoxy Lactone from a Blue-Green Alga

A novel lactone, gloeolactone (1), has been isolated from the blue-green alga, Gloeotrichia sp. The structure of this compound has been elucidated from a detailed analysis of the NMR spectra. This compound was shown to be toxic to brine shrimp.