Perceived improvements and challenges following sequential bilateral cochlear implantation in children and adults.

OBJECTIVE: Semi-structured interviews were conducted with sequentially implanted bilateral cochlear-implant (biCI) recipients to examine functional aspects of communication that are affected by listening with one versus two CIs. DESIGN: Participants were 15 adult biCI recipients and parents of 30 children (categorized into three groups by age) with biCIs. All CI users had sequential placement of biCIs with at least six months' experience with the first CI before activation of the second device, and at least three months' experience with both CIs prior to the interview. The parent/paediatric and adult interviews were all conducted by the same examiner. Electronic transcripts of the interview responses were coded for perceived changes or lack thereof in 23 behaviours following biCI. Extent of reported benefit was quantified for each subject within and across these behaviours and at the group level as a function of age. RESULTS: Most adults and parents of children reported multiple functional changes following biCI use, and changes often translated to enhanced social communication. Nearly all participants were consistent users of biCIs, and were satisfied with their perceived gains in communicating in everyday settings. Most reported ongoing challenges listening in noisy settings. Although many reports on children paralleled those of adults, developmental differences were apparent. Thirteen percent of adults and twenty percent of parents of children in each of the respective groups reported low levels of change. CONCLUSIONS: Results suggest that many biCI users experience meaningful functional benefits that may be underestimated by traditional outcome measures. We suggest the need to expand measurement approaches to better quantify the nature of these benefits.

ECAP spread of excitation with virtual channels and physical electrodes.

The primary goal of this study was to evaluate physiological spatial excitation patterns for stimulation of adjacent physical electrodes and intermediate virtual channels. Two experiments were conducted that utilized electrically evoked compound action potential (ECAP) spread-of-excitation (SOE) functions obtained with the traditional forward-masking subtraction method. These two experiments examined spatial excitation patterns for virtual-channel maskers and probes, respectively. In Experiment 1, ECAP SOE patterns were obtained for maskers applied to physical electrodes and virtual channels to determine whether virtual-channel maskers yield SOE patterns similar to those predicted from physical electrodes. In Experiment 2, spatial separation of SOE functions was compared for two adjacent physical probe electrodes and the intermediate virtual channel to determine the extent to which ECAP SOE patterns for virtual-channel probes are spatially separate from those obtained with physical electrodes. Data were obtained for three electrode regions (basal, middle, apical) for 35 ears implanted with Cochlear (N = 16) or Advanced Bionics (N = 19) devices. Results from Experiment 1 showed no significant difference between predicted and measured ECAP amplitudes for Advanced Bionics subjects. Measured ECAP amplitudes for virtual-channel maskers were significantly larger than the predicted amplitudes for Cochlear subjects; however, the difference was <2 µV and thus is likely not clinically significant. Results from Experiment 2 showed that the probe set in the apical region demonstrated the least amount of spatial separation amongst SOE functions, which may be attributed to more uniform nerve survival patterns, closer electrode spacing, and/or the tapered geometry of the cochlea. As expected, adjacent physical probes demonstrated greater spatial separation than for comparisons between each physical probe and the intermediate virtual channel. Finally, the virtual-channel SOE functions were generally weighted toward the basal electrode in the pair.

Effect of stimulus and recording parameters on spatial spread of excitation and masking patterns obtained with the electrically evoked compound action potential in cochlear implants.

OBJECTIVES: Spread of excitation within the cochlea in response to electrical stimulation can be measured with the electrically evoked compound action potential (ECAP). Different spread of excitation measurement techniques have been reported in the literature. One method uses a fixed stimulus location while varying the recording electrode along the length of the implanted array. This results in a relatively coarse estimate of spatial spread (SS) along the cochlea. Another method uses a forward-masking paradigm to evaluate the relative overlap of stimulated neural populations between electrodes. Both the probe and recording electrodes are fixed in location while a masker stimulus is systematically applied across electrodes. This method, which yields a more precise estimate of spatial excitation patterns, is termed spatial masking (SM). Five experiments were conducted to examine potential effects of stimulus and/or recording parameters on SS and SM patterns. Experiment 1 examined whether SS patterns were systematically broader than SM patterns across electrodes and subjects. Experiments 2 and 3 evaluated the effects of stimulus level on SS and SM patterns, respectively, to determine whether increased stimulus level systematically resulted in broader patterns. Experiment 4 evaluated whether recording electrode location affected SM patterns, and Experiment 5 evaluated whether SM patterns varied significantly across repeated trials within a test session. DESIGN: Data were collected for 27 ears in 26 adult and teenage subjects (N = 6 ears with Advanced Bionics CII, N = 8 ears with Advanced Bionics HiRes 90K, N = 10 ears with Nucleus 24R[CS], N = 3 ears with Nucleus 24RE[CA] Freedom). A standard forward-masking subtraction paradigm was used for all ECAP measures. For SS patterns, the masker and probe were fixed on the same electrode at the same level while the recording electrode varied across the remaining electrodes in the array. For SM patterns, the probe and recording locations were fixed while the masker location varied across all electrodes except the recording electrode. RESULTS: In experiment 1, SS patterns were broader than SM patterns. Subjects with Advanced Bionics devices exhibited relatively broad patterns for both measures, whereas Nucleus subjects typically exhibited narrower SM functions relative to SS functions. In experiments 2 and 3, there was a significant effect of stimulus level on the spread of both SS and SM patterns in roughly one-third of measures in each experiment. In experiment 4, there was a significant effect of recording electrode location on the width/spread of SM patterns for only 11.5% of comparisons. In experiment 5, there were no significant differences in SM amplitudes across repeated trials for 94% of comparisons, which suggests that ECAP measures are highly robust within a test session. CONCLUSIONS: Results showed that SS functions were generally broader than SM functions, which suggests that SS measures reflect volume conduction of the ECAP response along the length of the cochlea. Differences in the spread of SM functions across devices are likely due to differences in modiolar proximity between the respective electrode array designs. Stimulus level had a more significant effect on the spread of SM functions than recording electrode location. Finally, ECAP measures were shown to be highly stable across repeated measurements within a test session; however, repeatability was not assessed across sessions or over extended time intervals.

Psychophysical and physiological measures of electrical-field interaction in cochlear implants.

The primary purpose of this study was to determine whether the electrically evoked compound action potential (ECAP) can be used to predict psychophysical electrical-field interaction patterns obtained with simultaneous stimulation of intracochlear electrodes. The second goal was to determine whether ECAP patterns are affected by recording location because differences might influence the relation between ECAP and psychophysical measures. The third goal was to investigate whether symmetrical threshold shifts are produced with phase inversion of the interaction stimulus. Nine adults with Advanced Bionics cochlear implants participated. ECAP and psychophysical thresholds were obtained for basal, middle, and apical probe electrodes in the presence of a subthreshold interaction stimulus delivered simultaneously to each of seven to eight interaction electrodes per probe. The results showed highly significant correlations between ECAP and psychophysical threshold shifts for all nine subjects, which suggests that the ECAP can adequately predict psychophysical electrical-field interaction patterns for subthreshold stimuli. ECAP thresholds were significantly higher for recordings from the basal (versus apical) side of the probe, which suggests that recording location may affect relations between ECAP and psychophysical measures. Interaction stimulus phase inversion generally produced symmetrical threshold shifts for psychophysical measures but not for half of ECAP measures.

Psychophysical versus physiological spatial forward masking and the relation to speech perception in cochlear implants.

OBJECTIVES: The primary goal of this study was to determine if physiological forward masking patterns in cochlear implants are predictive of psychophysical forward masking (PFM) patterns. It was hypothesized that the normalized amount of physiological masking would be positively correlated with the normalized amount of psychophysical masking for different masker-probe electrode separations. A secondary goal was to examine the relation between the spatial forward masking patterns and speech perception performance. It was hypothesized that subjects with less channel interaction overall (either psychophysically or physiologically) would have better speech perception ability because of better spectral resolution. DESIGN: Data were collected for 18 adult cochlear implant recipients [N = 9 Clarion CII or HiRes 90K, N = 9 Nucleus 24R(CS)]. Physiological spatial forward masking patterns were obtained with the electrically evoked compound action potential (ECAP) through the implant telemetry system. PFM patterns were obtained using a three-interval, two-alternative forced-choice adaptive procedure. Both measures used a fixed probe electrode with varied masker location. For each subject, spatial forward masking patterns were obtained for three probe electrodes with five masker locations per probe. RESULTS: On an individual basis, the correlation between ECAP FM and PFM was strong for 10 subjects (r = 0.68-0.85, p 0.14). Results across subjects and electrodes showed a highly significant correlation between ECAP FM and PFM (r = 0.55, p < 0.0001); the correlation was strongest for basal electrodes. There was no significant correlation between speech perception and ECAP FM or PFM. Subjects whose ECAP FM patterns correlated well with PFM patterns generally had the poorest speech perception and subjects with the poorest correlations had the best speech perception. CONCLUSIONS: ECAP FM and PFM patterns correlated well for two-thirds of the subjects. Although the group correlation was statistically significant, ECAP FM patterns only accounted for 30% of the variance in the PFM measures. This suggests that the ECAP measures alone are not sufficient for accurately predicting PFM patterns for individual subjects.