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2.
Transplantation ; 24(3): 218-22, 1977 Sep.
Article in English | MEDLINE | ID: mdl-339432

ABSTRACT

Isogenic bone marrow transplantation was performed in "nude" and normal C3H mice after lethal doses of dimethylmyleran (DMM), meso-DMM, and (+/-) DMM were given. Nude mice were not more sensitive to DMM or its isomers than normal mice. With adequate cell doses in the range of 3 X 10(6) to 30 X 10(6) bone marrow cells or 10 X 10(6) to 30 X 10(6) spleen cels, the survival rate after lethal chemotherapy was not significantly different between nude mice reconstituted with a graft from nude donors and normal mice reconstituted with a graft from normal donors. Only with suboptimal cell dose (1 X 10(6) bone marrow cells) was survival superior in normal mice. Thinsic factor. Nude mice accepted also bone marrow grafts from allogeneic nude donors.


Subject(s)
Bone Marrow Transplantation , Busulfan/therapeutic use , Mice, Nude/immunology , Animals , Bone Marrow/drug effects , Busulfan/analogs & derivatives , Busulfan/poisoning , Mice , Mice, Inbred C3H , Species Specificity , Spleen/transplantation , Transplantation, Homologous , Transplantation, Isogeneic
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