1.
Biofizika
; 58(6): 981-6, 2013.
Article
in Russian
| MEDLINE
| ID: mdl-25486756
ABSTRACT
The study reports a thermodynamic model describing microarray oligo-target hybridization. The relationship between hybridization signal intensity and Gibbs free energy change for oligo-target duplex formation was our function of interest. The behavior of this function that we called energetical hybridization isotherm in response to target concentration change was modeled considering different ratios of oligo-probes/target concentrations. The results of modeling were compared with the relevant and currently available from literature microarray adsorption experiment.