Subject(s)
Cardiac Surgical Procedures/methods , Extracellular Matrix/transplantation , Foreign-Body Migration/pathology , Heart Defects, Congenital/surgery , Intestinal Mucosa/transplantation , Intestine, Small/transplantation , Adult , Animals , Biopsy , Cardiac Surgical Procedures/adverse effects , Child , Child, Preschool , Extracellular Matrix/pathology , Female , Foreign-Body Migration/etiology , Foreign-Body Migration/surgery , Heterografts , Humans , Infant, Newborn , Intestinal Mucosa/pathology , Intestine, Small/pathology , Male , Reoperation , Retrospective Studies , Sus scrofa , Time Factors , Treatment FailureABSTRACT
AIM: Bone osteoradionecrosis is a serious complication of radiation treatment. Current treatment approaches are not curative and treatment response is often poor leading to high social and healthcare costs. CASE REPORT: We report on the first case of osteoradionecrosis with successful restitutio ab integro by repeated administration of platelet gel (PLT-gel) and surgery in a critically ill patient. The administration of PLT-gel during a severe septic episode helped regeneration of bone and soft tissues, shortening the hospital stay of the patient. It was also noted that following applications of PLT-gel, both the use of morphine and the numbers of infective episodes were reduced. CONCLUSION: Additional studies are needed to confirm the promising effect of PLT-gel for the treatment of osteoradionecrosis.
