[Antialcoholic properties of a subalin probiotic drug].

Efficiency of a subalin probiotic drug created on the basis of live microbic cultures was investigated, at acute alcoholic intoxication developed in experimental animals. It was shown that after one time administration of this drug to animals there was no considerable influence on activity of the main enzymes of ethanol metabolism--alcohol- and aldehyde dehydrogenase both in animals with an alcoholic intoxication and without. However subalin induced considerable changes in the quantitative maintenance of acetaldehyde in blood of animals with alcoholic intoxication, which concentration decreased almost in 20 times.

[Metabolic changes in the rat liver during emotional stress]. / Narusheniia protsessov obmena veshchestv v pecheni krys pod vliianiem émotsional'nogo stressa.

Emotional stress of rats is accompanied by essential alterations in glycolysis and tricarboxylic acid cycle in the liver. These alterations were observed over a few days after the termination of stressor action. Perhaps it is one of the trigger mechanisms responsible for pathological changes in the organism.

[Change in the intensity of biosynthesis of proteins, lipids and glycogen in animal tissues during long-term administration of morphine]. / Izmenenie intensivnosti biosinteza belkov, lipidov i glikogena v tkaniakh zhivotnykh pri dlitel'nom vvedenii morfina.

The intensity of biosynthesis processes in animal organism has been studied as affected by long-term administration of morphine. It was established that morphine administration to rats for five weeks intensified protein biosynthesis in the brain, kidneys, skeletal muscles: specific radioactivity of blood serum proteins also increased. Incorporation of 2-/14C/glycine label to the brain, cardiac and skeletal muscles increased as affected by morphine: the label incorporation to the liver lipids decreased and that to the kidney and spleen lipids did not change. Specific radioactivity of glycogen multiply increased in the rat liver as affected by morphine.

[Redox processes in the retina and tunic tissues of the rat eye in experimental alkalosis]. / Okislitel'no-vosstanovitel'nye protsessy v tkaniakh setchatki i sosudistoi obolochki glaza krys pri éksperimental'nom alkaloze.

It is shown in experiments is vivo that development of experimental metabolic alkalosis in rats is followed by changes in redox processes in the eye retina and tunic. For the first two months of the experiment the number of sulphydryl group decreases, while that of disulphide ones of water-soluble proteins and low-molecular compounds increases. The amount of oxidized metabolites of glycolysis and of a cycle of tricarboxylic acids (pyruvate, oxaloacetate, alpha-ketoglutarate) increases relative to the reduced ones (lactate, isocitrate, malate), as well as activities of hexokinase, pyruvate kinase, NAD-dependent malate dehydrogenase, while activities of fructose diphosphatase, glucoso-6-phosphate dehydrogenase, glutathione peroxidase and glutathione reductase fall. The content of malonic dialdehyde increases. 90 days later disorders of certain compensatory mechanisms of the metabolic system of alkalosis regulation probably occurred in the eye retina and tunic tissues: hexokinase and pyruvate kinase activity fell to the control values, while that of NAD-dependent malate dehydrogenase--below the control level; the content of lactate increased. Activity of glutathione-dependent enzymes remained low and the amount of malonic dialdehyde grew much more than in the previous terms.

[Features of metabolic disorders in the liver during morphine poisoning of various duration]. / Osobennosti metabolicheskikh narushenii v pechenii pri morfinnoi intoksikatsii razlichnoi dlitel'nosti.

Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.

[Correction with formate of metabolic disorders in alcoholic intoxication]. / Korrektsiia formiiatom metabolicheskikh narushenii pri alkogol'noi intoksikatsii.

Formate was studied for its effect on the content of acetaldehyde, activity of the total aldehyde dehydrogenase, content of substrates of glycolysis and tricarbonic-cycle and pool of free amino acids of rat tissues during alcohol intoxication. The introduction of formate during the acute alcohol intoxication lowers the acetaldehyde content in the blood; the ethanol load being prolonged--it increases the activity of aldehyde dehydrogenase and normalizes the content of pyruvate, glutamate and malate in the liver and glutamate and oxaloacetate in the brain, that evidences for the correction of metabolic disturbances in the organism.

[Effect of carbostimulin on metabolism in rats with deep burns]. / Vliianie karbostimulina na obmen veshchestv u krys pri ozhogovoi bolezni.

It is established that at early stages of the burn disease (deep burn of III-B degree, 20% of body surface) in rats there appears metabolic acidosis, the content of urea increases in the liver and blood serum, a pronounced hydration of the liver and muscles is observed in the burn zone. Administration per os of carbostimulin just a day after burn removes symptoms of metabolic acidosis. When the preparation is fed to rats during 7 days after burn the intensity of radioactive label incorporation into proteins, lipid and glycogen of the liver as well as in proteins and lipids of kidneys and spleen increases.

[Effect of carboxylation reactions stimulation on intensity of 14CO2 fixation in rabbits with posthemorrhage anemia and on repairing of blood components in human anemia]. / Vpliv stimuliatsii karboksiliuvannia na intensivnist' fiksatsii 14CO2 u kroliv z postgemoragichnoiu anemieiu ta na vidnovlennia komponentiv krovi u liudei za anemii.

The repair processes with posthemorrhage anemia were studied in experiment and clinics as affected by the preparation (sodium bicarbonate and magnesium, manganese and zinc sulphates in a ratio of 25:5:0.1:0.1) which stimulates the carboxylation reactions in the organism. Stimulation of the carboxylation reactions in the rabbits with experimental posthemorrhage anemia increases the intensity of 14CO2 carbon transformation of organic compounds in the tricarboxylic cycle, intensifies 14C incorporation into the liver, kidneys, spleen and marrow proteins as well as into serum albumin and globulins. Under clinical conditions stimulation of CO2 fixation with the preparation favours an intensified formation of the red series cells and biosynthesis of hemoglobin and serum proteins as well as the repair of their disturbed balance in patients with posthemorrhage anemia. The content of magnesium in blood plasma normalizes.