ABSTRACT
Investigation of the blood sera of patients with fresh syphilis forms before, immediately after, and in 6-18 months after treatment has confirmed a high sensitivity of the serologic tests for syphilis used in this country. The results of dynamic serologic monitoring of patients have demonstrated high efficacy of the therapeutic method used.
Subject(s)
Antibodies, Bacterial/biosynthesis , Penicillin G Procaine/administration & dosage , Syphilis/immunology , Treponema pallidum/immunology , Antibodies, Bacterial/blood , Drug Evaluation , Humans , Syphilis/drug therapy , Syphilis Serodiagnosis , Time FactorsABSTRACT
A clinical and serologic follow-up of 307 BALB/c mice and 12 rabbits injected with the blood and brain and spinal tissue of mice infected with 5 strains of T. pallidum has demonstrated the possibility of a prolonged (up to 465 days) preservation of pathogenic T. pallidum strains in these mice, as well as the regularity of a syphilitic infection development in rabbits. This permits recommending T. pallidum pathogenic strains to be maintained in mice at laboratories of institutions for skin and sexually transmitted diseases where experimental and diagnostic studies with the use of specific serologic tests for syphilis are carried out.
Subject(s)
Mice, Inbred BALB C/microbiology , Preservation, Biological/methods , Treponema pallidum/pathogenicity , Animals , Male , Mice , Rabbits , Serial Passage/methods , Syphilis/microbiology , Time FactorsABSTRACT
The results of rapid single-course oletetrine and tetracycline therapy of early syphilis are analyzed. The time of Treponema pallidum disappearance from syphilid discharge, of syphilid regression, and of the first negative results of the routine serologic tests, immunofluorescence 200/ABC and T. pallidum immobilization tests, as well as the blood serum tetracycline level indicate a high therapeutic efficacy of this method and recommend it for wide use.
