Surgical Treatment Strategies for Injuries of the "Unforgiving" Superficial Branch of the Radial Nerve.

BACKGROUND: Neuropathic pain caused by adhesions or neuroma formation of the superficial branch of the radial nerve (SBRN) is difficult to treat. The authors evaluated the effectiveness of different routinely used surgical techniques for SBRN neuralgia to provide a basis for future studies on SBRN neuralgia and explored the prognostic value of a preoperative diagnostic nerve block. METHODS: The authors performed a retrospective cohort study by reviewing surgical records for procedures to treat SBRN neuralgia. Patient satisfaction was scored as satisfied or unsatisfied, and pain intensity was scored with a numeric rating scale. RESULTS: The authors included 71 patients who had 105 surgeries on the SBRN. Patients with a neuroma ( n = 43) were most satisfied after proximal denervation with burying into the brachioradialis muscle compared with burying elsewhere (53 versus 0 percent; p < 0.001). Adhesions of the SBRN ( n = 28) were treated with neurolysis (39 percent satisfied). If neurolysis or denervation did not suffice, an additional denervation of the lateral antebrachial cutaneous nerve or posterior interosseous nerve led to satisfaction in 38 percent. A decrease of less than 3.5 points on the numeric rating scale score after diagnostic nerve block led to higher postoperative pain scores (4.0 versus 7.5; p = 0.014). The authors found that the outcome of the diagnostic nerve block can predict the outcome of SBRN denervation and burying into brachioradialis muscle. CONCLUSIONS: The most effective burying technique is burying the SBRN into the brachioradialis muscle. Future studies on the treatment of SBRN neuralgia should therefore compare newer techniques, with burying the SBRN into the brachioradialis muscle as the control group.

[Operative treatment of painful neuromas]. / Operatieve behandeling van pijnlijke neuromen.

3-5% of patients with traumatic or iatrogenic peripheral nerve injury develop a painful neuroma, especially following trauma of small cutaneous sensory nerve branches. Neuroma pain is difficult to treat and often leads to loss of function and reduction of quality of life. Patients with a painful neuroma present with spontaneous electric, shooting or burning pain, allodynia, hyperalgesia and cold intolerance. The diagnosis is based on the medical history and physical examination, supplemented by Tinel's test and a diagnostic nerve blockade. Lasting pain relief is possible by means of surgical neuroma treatment performed by a plastic surgeon. Surgical treatment consists of repair or denervation of the nerve with relocation of the nerve stump in bone or muscle tissue or a vein. Referral of neuroma patients without delay to a plastic surgeon or multidisciplinary consultation is important, because the symptoms become increasingly difficult to treat over time. 3-5% of patients with traumatic or iatrogenic peripheral nerve injury develop a painful neuroma, especially following trauma of small cutaneous sensory nerve branches. Neuroma pain is difficult to treat and often leads to loss of function and reduction of quality of life. Patients with a painful neuroma present with spontaneous electric, shooting or burning pain, allodynia, hyperalgesia and cold intolerance. The diagnosis is based on the medical history and physical examination, supplemented by Tinel's test and a diagnostic nerve blockade. Lasting pain relief is possible by means of surgical neuroma treatment performed by a plastic surgeon. Surgical treatment consists of repair or denervation of the nerve with relocation of the nerve stump in bone or muscle tissue or a vein. Referral of neuroma patients without delay to a plastic surgeon or multidisciplinary consultation is important, because the symptoms become increasingly difficult to treat over time.

Surgical management of neuroma pain: a prospective follow-up study.

Painful neuromas can cause severe loss of function and have great impact on the daily life of patients. Surgical management remains challenging; despite improving techniques, success rates are low. To accurately study the success of surgical neuroma treatment and factors predictive of outcome, a prospective follow-up study was performed. Between 2006 and 2009, pre- and post-operative questionnaires regarding pain (VAS, McGill), function (DASH), quality of life (SF-36), symptoms of psychopathology (SCL-90), epidemiologic determinants and other outcome factors were sent to patients surgically treated for upper extremity neuroma pain. Pain scores after diagnostic nerve blocks were documented at the outpatient clinic before surgery. Thirty-four patients were included, with an average follow up time of 22 months. The mean VAS score decreased from 6.8 to 4.9 after surgery (p<0.01), 19 (56%) of patients were satisfied with surgical results. Upper extremity function improved significantly (p=0.001). Neuroma patients had significantly lower quality of life compared to a normal population. Employment status, duration of pain and CRPS symptoms were found to be prognostic factors. VAS scores after diagnostic nerve block were predictive of post-operative VAS scores (p=0.001). Furthermore, smoking was significantly related to worse outcome (relative risk: 2.10). The results could lead to improved patient selection and treatment strategies. If a diagnostic nerve block is ineffective in relieving pain, patients will most likely not benefit from surgical treatment. Patients should be encouraged to focus on activity and employment instead of their symptoms. Smoking should be discouraged in patients who will undergo surgical neuroma treatment.

Insufficient pain relief after surgical neuroma treatment: Prognostic factors and central sensitisation.

BACKGROUND: Treatment of patients with neuromatous pain is difficult. Numerous treatment methods have been described, but none has been completely effective in providing sufficient pain relief. Patient-specific prognostic factors, predicting pain after surgical neuroma treatment, can help clinicians in the process of patient treatment and care. METHODS: A computerised bibliographical database (PubMed Medline) was searched for articles concerning prognostic factors predicting the outcome of surgical neuroma treatment, and all the reference lists were checked. RESULTS: Evidence for predicting the outcome was found for neuromas of the radial sensory branch and digital nerves, discrete nerve syndrome, workers compensation, employment status, litigation involvement, duration of pain and number of previous operations. Psychosocial problems are often found in neuroma patients. In chronic neuropathic pain patients, changes in the central nervous system at the level of spinal cord and in the somatosensory cortex can be found. CONCLUSIONS: Neuromas of the radial sensory branch and digital nerves, discrete nerve syndrome, workers' compensation, employment status, litigation involvement, duration of pain and number of previous operations appear to predict the amount of pain after neuroma surgery. However, in a minority of patients, a bad outcome cannot be explained by these factors; in these patients, central sensitisation and psychosocial factors may play a role in maintaining pain. Research focussing on prognostic factors and the central changes induced by painful peripheral injury can lead to new and improved clinical treatment algorithms for the relief and prevention of chronic neuropathic pain.

Cold intolerance in surgically treated neuroma patients: a prospective follow-up study.

PURPOSE: Cold intolerance may impose great changes on patients' lifestyle, work, and leisure activities, and it is often severely disabling. This study aims to investigate the prevalence and severity of cold intolerance in patients with injury-related neuromas of the upper extremity and improvement of symptoms after surgical treatment. Furthermore, we try to find predictors for cold intolerance and correlations with other symptoms. METHODS: Between January 2006 and February 2009, 34 consecutive patients with surgically treated neuroma-specific neuropathic pain of the upper extremities were sent a questionnaire composed of general questions concerning epidemiologic variables and several specific validated questionnaires, including the Visual Analog Scale for pain. To estimate the prevalence of cold intolerance objectively in neuroma patients, we used the validated CISS (Cold Intolerance Symptom Severity) questionnaire with a prespecified cutoff point. RESULTS: The CISS questionnaire was filled out by 33 patients before and 30 after surgery for neuroma-specific neuropathic pain, with a mean follow-up time of 24 months. We found a prevalence of cold intolerance of 91% before surgery, with a mean CISS score above the cutoff point for abnormal cold intolerance. After surgery, the prevalence of cold intolerance and the mean CISS score were not significantly different, whereas the mean Visual Analog Scale score decreased significantly (p < .01). CISS scores were lower in patients with neuromas associated with sharp injury of the peripheral nerve (p = .02). A higher VAS score correlated significantly with a higher CISS score (p = .01). CONCLUSIONS: Cold intolerance is a difficult and persistent problem that has a high prevalence in patients with a painful injury-related neuroma. There seems to be a relationship between severity of cold intolerance as measured by CISS, pain as measured by the Visual Analog Scale, and type of injury. Cold intolerance may not disappear with time or surgical treatment. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

Stent placement or brachytherapy for palliation of dysphagia from esophageal cancer: a prognostic model to guide treatment selection.

BACKGROUND: Brachytherapy was found to be preferable to metal stent placement for the palliation of dysphagia because of inoperable esophageal cancer in the randomized SIREC trial. The benefit of brachytherapy, however, only occurred after a relatively long survival. The objective is to develop a model that distinguishes patients with a poor prognosis from those with a relatively good prognosis. METHODS: Survival was analyzed with Cox regression analysis. Dysphagia-adjusted survival (alive with no or mild dysphagia) was studied with Kaplan-Meier analysis. Patient data is from the multicenter, randomized, controlled trial (SIREC, n = 209) and a consecutive series (n = 396). Patients received a stent or single-dose brachytherapy. RESULTS: Significant prognostic factors for survival included tumor length, World Health Organization performance score, and the presence of metastases (multivariable p < 0.001). A simple score, which also included age and gender, could satisfactorily separate patients with a poor, intermediate, and relatively good prognosis within the SIREC trial. For the poor prognosis group, the difference in dysphagia-adjusted survival was 23 days in favor of stent placement compared with brachytherapy (77 vs. 54 days, p = 0.16). For the other prognostic groups, brachytherapy resulted in a better dysphagia-adjusted survival. CONCLUSIONS: A simple prognostic score may help to identify patients with a poor prognosis in whom stent placement is at least equivalent to brachytherapy. If further validated, this score can provide an evidence-based tool for the selection of palliative treatment in esophageal cancer patients.