Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.

Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons are required for the production and specification of the proper number of layer 4 neurons in primary sensory areas by the neonatal stage. Part of these area-specific roles is played by the thalamus-derived molecule, VGF. Our work reveals that extrinsic cues from sensory thalamic projections have an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.

Action errors impair active working memory maintenance.

The ability to detect and correct action errors is paramount to safe and efficient behavior. Its underlying processes are subject of intense scientific debate. The recent adaptive orienting theory of error processing (AOT) proposes that errors trigger a cascade of processes that purportedly begins with a broad suppression of active motoric and-crucially-cognitive processes. While the motoric effects of errors are well established, an empirical test of their purported suppressive effects on active cognitive processes is still missing. Here, we provide data from seven experiments that clearly demonstrate such effects. Participants maintained information in working memory (WM) and performed different response conflict tasks during the delay period. Motor error commission during the delay period consistently reduced accuracy on the WM probe, demonstrating an error-related impairment of WM maintenance. We discuss the broad theoretical and practical implications of this finding, both for the AOT and beyond. (PsycInfo Database Record (c) 2022 APA, all rights reserved).