Subject(s)
Amino Acids, Cyclic , Amino Acids/isolation & purification , Antimetabolites/isolation & purification , Cyclobutanes/isolation & purification , Herbicides/isolation & purification , Streptomyces/metabolism , Amino Acids/pharmacology , Antimetabolites/metabolism , Antimetabolites/pharmacology , Cyclobutanes/pharmacology , Fermentation , Herbicides/metabolism , Herbicides/pharmacology , Structure-Activity RelationshipABSTRACT
The structures of five naturally-occurring herbicidal nucleosides have been determined by spectral analysis. Three (5'-deoxyguanosine, coaristeromycin and 5'-deoxytoyocamycin) are novel natural products while the remaining two (coformycin and adenine 9-beta-D-arabinofuranoside) are known natural products which have not previously been reported to be herbicidal.
Subject(s)
Actinomycetales/metabolism , Deoxyguanosine/analogs & derivatives , Herbicides/chemistry , Inosine/analogs & derivatives , Nucleosides/chemistry , Toyocamycin/analogs & derivatives , Chromatography, High Pressure Liquid , Coformycin/chemistry , Coformycin/isolation & purification , Deoxyguanosine/chemistry , Deoxyguanosine/isolation & purification , Fermentation , Herbicides/isolation & purification , Inosine/chemistry , Inosine/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Nucleosides/isolation & purification , Purine Nucleosides/chemistry , Purine Nucleosides/isolation & purification , Toyocamycin/chemistry , Toyocamycin/isolation & purification , Vidarabine/chemistry , Vidarabine/isolation & purificationSubject(s)
Fatty Acids, Monounsaturated/isolation & purification , Fungi/metabolism , Herbicides/isolation & purification , Fatty Acids, Monounsaturated/chemistry , Fatty Acids, Monounsaturated/pharmacology , Fermentation , Herbicides/chemistry , Herbicides/pharmacology , Magnetic Resonance Spectroscopy , Molecular Structure , Solubility , SpectrophotometryABSTRACT
5,8 alpha-Epidioxy-(22E)-24-nor-5 alpha-cholesta-6,22-dien-3 beta-ol (8 approximately) has been isolated from the sea pen Virgularia sp. and has been observed as a component of a mixture isolated from the opisthobranch mollusk Adalaria sp. The structure of 8 approximately was deduced from spectroscopic data. A further six sterol peroxides isolated from Adalaria and six from Virgularia were tentatively identified on the basis of spectroscopic analysis of mixtures.
