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4.
J Cutan Pathol ; 49(12): 1025-1030, 2022 Dec.
Article in English | MEDLINE | ID: mdl-35751643

ABSTRACT

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.


Subject(s)
Skin Neoplasms , Humans , Skin Neoplasms/genetics , Skin Neoplasms/pathology , Gene Fusion , Transcription Factors/genetics , Melanocytes/pathology , Biomarkers, Tumor , Tripartite Motif Proteins/genetics , Ubiquitin-Protein Ligases/genetics
7.
Pediatr Dermatol ; 38(2): 477-480, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33534174

ABSTRACT

Whitening of the nail, or leukonychia, can have a wide range of etiologies including genetic disorders, trauma, poisoning, autoimmune disorders, and infections. Here we detail a case of idiopathic acquired leukonychia totalis in a 17-year-old boy. This condition has been reported 13 times in the literature previously, with only young boys being affected. Proper diagnosis may help minimize unnecessary investigations and prevent additional psychological stress over whether an underlying disease is present.


Subject(s)
Hypopigmentation , Nail Diseases , Adolescent , Humans , Male , Nail Diseases/congenital , Nail Diseases/diagnosis , Nail Diseases/etiology , Nails
12.
J Cutan Pathol ; 46(3): 238-241, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30582191

ABSTRACT

Primary cutaneous Ewing sarcoma is a rare clinical presentation of Ewing sarcoma, usually occurring as a small, localized tumor on the extremities of young adults and associated with favorable prognosis. We report a case of primary cutaneous Ewing sarcoma, which presented on the sole of the foot of a 27-year-old patient with relapsed acute myeloid leukemia and neutropenia. Diagnosis was determined through histological features and staining, as well as fluorescence in situ hybridization and molecular testing. The patient underwent wide-local excision with plan to begin targeted chemotherapy, but unfortunately died from adenovirus pneumonia while neutropenic before targeted chemotherapy was initiated.


Subject(s)
Immunocompromised Host , Leukemia, Myeloid, Acute/complications , Neutropenia/complications , Sarcoma, Ewing/immunology , Skin Neoplasms/immunology , Adult , Female , Humans
16.
Pediatr Dermatol ; 33(1): e16-9, 2016.
Article in English | MEDLINE | ID: mdl-26645569

ABSTRACT

Plaque-like CD34-positive dermal fibromas, also known as medallion-like dermal dendrocyte hamartomas (MDDHs), are a recently recognized group of congenital and acquired spindle cell neoplasms that may appear histologically similar to dermatofibrosarcoma protuberans. Recognizing the clinical heterogeneity of this neoplasm and the subtle pathologic differences are crucial to making the correct diagnosis and avoiding the aggressive surgical intervention required to treat a dermatofibrosarcoma protuberans. We present the case of a 9-year-old girl with an acquired variant of a plaque-like CD34-positive dermal fibroma without clinical epidermal change. Our case expands the clinical spectrum to include an acquired variant of a plaque-like CD34-positive dermal fibroma without clinical epidermal change. Examination of more cases is needed to determine whether all clinical variants are truly subtypes of the same neoplasm or represent distinct CD34-positive spindle cell proliferations.


Subject(s)
Antigens, CD34/metabolism , Fibroma/pathology , Skin Neoplasms/pathology , Child , Diagnosis, Differential , Female , Fibroma/metabolism , Humans , Skin Neoplasms/metabolism
18.
Am J Dermatopathol ; 37(10): 790-4, 2015 Oct.
Article in English | MEDLINE | ID: mdl-25747810

ABSTRACT

IMPORTANCE: Posttransplant lymphoproliferative disorder (PTLD) is an uncommon complication after solid organ transplants and hematopoietic stem cell transplants. Extranodal involvement in PTLD can involve several organ systems, including the central nervous system, bone marrow, lungs, gastrointestinal tract, and skin. Isolated involvement of the skin without systemic involvement in PTLD is rare. Primary cutaneous PTLD is generally categorized as either cutaneous T-cell lymphomas or cutaneous B-cell lymphomas, with variable Epstein-Barr virus (EBV) positivity. Herein, we describe an exceedingly uncommon case of a polymorphic variant of primary cutaneous PTLD. OBSERVATIONS: A woman in her 30s, who received an EBV+ deceased donor kidney transplant, presented with a 2-week history of 2 indurated patches over the lower abdomen. A skin biopsy revealed an atypical lymphoid proliferation with immunohistochemical stains demonstrating a mixed population of both B and T cells that stained strongly positive for EBV-encoded RNA. A bone marrow biopsy and positron emission tomography/computed tomography were negative for systemic involvement. The patient was treated with immunosuppression reduction and rituximab infusions. CONCLUSIONS AND RELEVANCE: This case highlights a rare polymorphic variant of primary cutaneous EBV-associated PTLD and increases awareness of this uncommon posttransplant complication. Cutaneous PTLD is reviewed, therefore dermatologists are aware of this uncommon disorder.


Subject(s)
Epstein-Barr Virus Infections/virology , Herpesvirus 4, Human/isolation & purification , Kidney Transplantation/adverse effects , Lymphoproliferative Disorders/virology , Skin Diseases, Viral/virology , Adult , Biopsy , Epstein-Barr Virus Infections/drug therapy , Epstein-Barr Virus Infections/immunology , Epstein-Barr Virus Infections/pathology , Female , Herpesvirus 4, Human/immunology , Humans , Immunohistochemistry , Immunologic Factors/therapeutic use , Immunosuppressive Agents/adverse effects , Lymphoproliferative Disorders/drug therapy , Lymphoproliferative Disorders/immunology , Lymphoproliferative Disorders/pathology , Positron-Emission Tomography , Rituximab/therapeutic use , Skin Diseases, Viral/drug therapy , Skin Diseases, Viral/immunology , Skin Diseases, Viral/pathology , Tomography, X-Ray Computed , Treatment Outcome
20.
J Low Genit Tract Dis ; 18(3): e80-3, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24402357

ABSTRACT

OBJECTIVE: Vulvar ulcers may be caused by various etiologies including infection, trauma, dermatosis, and cancer. We report a case of a vulvar ulcer caused by botryomycosis. CASE: An 85-year-old woman presented with vulvar itching, pain, bleeding, and ulcerations suspicious for cancer. Biopsies of the ulcers returned without dysplasia or malignancy. She was referred to the tertiary care vulvar vaginal disease clinic. Dermatopathologic reevaluation of pathologic slides diagnosed lichen sclerosus and botryomycosis. The patient was treated with ciprofloxacin for 7 weeks with complete resolution of vulvar ulcerations. CONCLUSION: Botryomycosis should be included in the differential diagnosis of infectious etiology of vulvar ulcers.


Subject(s)
Botrytis/isolation & purification , Mycoses/diagnosis , Mycoses/pathology , Ulcer/etiology , Ulcer/pathology , Vulvar Diseases/diagnosis , Vulvar Diseases/pathology , Aged, 80 and over , Female , Humans , Mycoses/microbiology , Ulcer/microbiology , Vulvar Diseases/microbiology
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