[Cytologic picture of medullary carcinoma of the thyroid gland]. / K cytologickému obrazu medulárního karcinomu stítné zlázy.

The authors present cytological and clinical features of six cases of medullary carcinoma of the thyroid. They are quoting a review of the literature about the cytological picture of medullary carcinoma of the thyroid and they draw attention to the advances of immunocytology.

Niemann-Pick disease type C with enhanced glycolipid storage. Report on further case of so-called lactosylceramidosis.

A case of infantile neurovisceral disease was classified according to the morphological and chemical analysis of fixed tissue as a chemically different type of Niemann-Pick disease (NPD) type C, with glycolipids dominating the storage process. The diagnosis was reached on the basis of massive accumulation of neutral glycolipids in visceral storage elements (hepatocytes and macrophages) as an outstanding feature of lipid histochemistry. Chemical lipid analysis corroborated the findings by detecting a manyfold increase of glucosyl ceramide, lactosyl ceramide, ceramide trihexoside and GM3 ganglioside. In addition, macrophages contained variable quantities of sphingomyelin. The brain showed slightly increased quantities of lactosylceramide (Slower fraction) and glucosyl ceramide. Apart from the classical neuronal storage changes there was also marked neuroaxonal dystrophy. In terms of quality, the glycolipid spectrum was comparable to that of NPD type C, in terms of quantity, the changes were consistent with those in so-called lactosylceramidosis, which, however, was reclassified as NPD type C only recently. In our view, the present case is the second published observation of lactosylceramidosis classifiable as a glycolipid (GL) variety of NPD type C in which the normally considerable tendency to glycolipid storage is further enhanced while the storage of sphingomyelin is less expressed.

[Morphological findings on the endometrium, decia and chorion following long-term use of intrauterine anticonceptive devices]. / Morflologické nálezy na endometriu, decidui a chóriu po dlhsie trvajúcom pouzití intrauterinného antikoncepcného telieska.

PIP: 60 endometrial biopsies were taken from women who had metrorrhagia, menorrhagia, or some other endometrial disease contracted through the prolonged use of an IUD, and from women who became pregnant with the device in place. No serious morphological changes in the endometrium, chorion laeve, and in the adjacent parietal decidua were revealed. Foci showing signs of flattening and the eventual disappearance of superficial epithelium, edema, and fibrosis of subepithelial stromal layer of endometrium are thought to be caused by pressure of the contraceptive device on the surrounding tissue. 1 case of terminal gravidity after 9-24 months of IUD use is described in detail, showing that the IUD had no teratogen influence on the pregnancy.^ieng