ABSTRACT
Kaposiform hemangioendothelioma is a locally aggressive, endothelial-derived spindle cell neoplasm that occurs exclusively in infants and adolescents. Lesions are characterized by rapid growth and extension, and are often associated with Kasabach-Merritt syndrome and lymphangiomatosis. Clinically nonspecific, they can appear as tender rapidly expanding red plaques, nodules, grouped papules, or telangiectasias. The histology is distinctive, however, as it combines features of tufted angioma, progressive lymphangioma, and Kaposi's sarcoma in a characteristic pattern. We describe a patient with kaposiform hemangioendothelioma currently controlled with systemic prednisone.
Subject(s)
Hemangioendothelioma/diagnosis , Skin Neoplasms/diagnosis , Vascular Neoplasms/diagnosis , Adolescent , Antineoplastic Agents, Hormonal/therapeutic use , Disseminated Intravascular Coagulation/pathology , Endothelium, Vascular/pathology , Glucocorticoids/therapeutic use , Hemangioendothelioma/drug therapy , Hemangioendothelioma/pathology , Hemangioma/pathology , Humans , Lymphangioma/pathology , Male , Neoplasm Invasiveness , Prednisone/therapeutic use , Sarcoma, Kaposi/pathology , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Syndrome , Telangiectasis/diagnosis , Telangiectasis/pathology , Thrombocytopenia/pathology , Vascular Neoplasms/drug therapy , Vascular Neoplasms/pathologyABSTRACT
BACKGROUND AND OBJECTIVE: The objective of this study was to establish the 585 nm flashlamp-pulsed tunable dye laser (PTDL) as a potentially effective modality in the treatment of plantar verrucae. Furthermore, this study attempted to identify if certain regions of the plantar surface yielded a different clearance rate in comparison to others. STUDY DESIGN/MATERIALS AND METHODS: Thirty-three patients were recruited for this case series study, representing a total of 97 plantar warts. Patients were treated using the flashlamp-PTDL with a pulse duration of 450 microseconds, a spot diameter of 5.0 mm, and energy fluences ranging between 8.1 and 8.4 J/cm2. Patients were followed-up an average of 2-24 weeks assessing for recurrence of verrucae. RESULTS: Each patient exhibited one to eight plantar lesions. Of the 97 verrucae treated by the flashlamp-PTDL, 68 (70.1%) resolved with 100% clearance of the lesion. The overall mean clearance of the 97 lesions was 95.1 +/- 16.5%. Of the 97 lesions treated to maximal clearance, 14 lesions recurred after a mean follow-up period of 9.0 weeks. CONCLUSION: Results of this study have established the 585 nm flashlamp-pulsed tunable dye laser as a potentially effective modality treatment of plantar warts. Furthermore, it was determined that there was no significant difference in the clearance rate of warts located at a given plantar site when compared to the clearance rates of the other plantar sites (F3/44 = 0.58, P = 0.634).
Subject(s)
Foot Dermatoses/radiotherapy , Laser Therapy , Warts/radiotherapy , Adolescent , Adult , Child , Female , Foot Dermatoses/pathology , Humans , Male , Middle Aged , Radiotherapy Dosage , Treatment Outcome , Warts/pathologyABSTRACT
In pyodermatitis-pyostomatitis vegetans annular pustular cutaneous lesions may precede, accompany, or follow the usually extensive vegetating oral disease. Sometimes only cutaneous or only oral lesions occur and previously have been described as separate entities. Clinical, histopathologic, and immunopathologic evidence clearly indicates this is one disease and suggests that it is distinct from pemphigus vegetans. The association between pyodermatitis-pyostomatitis vegetans and inflammatory bowel disease, most commonly ulcerative colitis, has been amply confirmed. Pyodermatitis-pyostomatitis vegetans should be considered a marker for inflammatory bowel disease.
