Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Publication year range
2.
Pacing Clin Electrophysiol ; 21(1 Pt 2): 227-30, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9474677

ABSTRACT

This study investigates the influence of various lead geometry on intracardial signals like the monophasic action potential (MAP) to optimize the geometry of implantable MAP leads. The experimental results were compared with a field theoretical approach to the origin of MAP from the transmembrane potential (TAP). During the experiments several lead geometries (tip surface: 1.3 to 12 mm2; tip-ring distance: 0.8 mm to 25 cm; ring surface: 1.8 mm2 to 40 mm2) were investigated in endo- and epicardial positions in 12 dogs (17 +/- 9 kg). The electrodes were fixed passively (tines) or actively (screws). MAP was recorded during several interventions and correlated with MAP measured using an Ag-AgCl MAP catheter. The experimental results showed that small tips provided high MAP amplitudes with less pressure. No difference was observed using active and passive fixations. A tip-ring distance smaller than 5 mm with a ring surface smaller than the tip (< 5 mm2) avoided artifacts in the repolarization course. For the theoretical approach the quasistatic, anisotropic bidomain model was calculated in small unity volumes Vi where the TAP phi mi was constant and represented by the current density Ji. Two solutions for electrode positions at and outside the heart were achieved. By superposition of each solution phi ei the summed potential at the electrode position was calculated. The theoretical findings show in good correlation with the experimental results that a larger distance than 10 mm leads to distortions in repolarization course by signals proportional to phi out.


Subject(s)
Action Potentials , Electrodes, Implanted , Heart Conduction System/physiology , Animals , Cardiac Catheterization , Dogs , Equipment Design , Fractals , Iridium , Membrane Potentials , Models, Cardiovascular , Pacemaker, Artificial , Surface Properties
3.
Pacing Clin Electrophysiol ; 21(1 Pt 2): 231-4, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9474678

ABSTRACT

Ag/AgCl and Ir-coated electrodes allow the recording of the monophasic action potential (MAP) due to their electrical properties like non-polarisability. This study investigates the correlation of MAP recorded with both types of electrodes. In 20 mongrel dogs (18 +/- 6 kg) an Ag/AgCl and an Ir-coated catheter (Ir) were placed endocardially in the apex of the right ventricle. The effects of isoproterenol and verapamil were investigated during spontaneous rhythm and stimulation simultaneously recorded with both types of electrodes in 10 dogs without AV-node ablation. The correlation at different heart rates were investigated in 10 other dogs with complete AV-block. The morphology and amplitudes of MAP were comparable (AgCl: 15 +/- 7 mV; Ir: 13 +/- 8 mV). Following an i.v. bolus of 2 micrograms/kg isoproterenol the spontaneous rate increased (175 +/- 18 to 245 +/- 25 bpm). During stimulation with 250 ms cycle length the duration shortened (MAPd90: AgCl: 160 +/- 11 to 130 +/- 12 ms; Ir: 154 +/- 18 to 128 +/- 15 ms). The alterations reversed after 20 min. An i.v. bolus of 0.2 mg/kg verapamil decreased the spontaneous rate (167 +/- 11 to 104 +/- 23 bpm) and lengthened the MAPd90 (AgCl: 182 +/- 14 to 220 +/- 13 ms; Ir: 174 +/- 16 to 216 +/- 21 ms) at 300 ms stimulation. The correlation between the MAPd90 of both lead types was r = 0.98 during all measurements. Under the effect of beta-agonist and Ca(2+)-antagonist medication MAP showed a strong correlation recorded with both types of electrodes. Thus, both leads allow the recording of MAP but only the Ir-electrodes with their long-term stability are implantable and allows us to control the effects of drugs with implantable devices.


Subject(s)
Action Potentials , Electrodes, Implanted , Heart Conduction System/physiology , Iridium , Silver Compounds , Action Potentials/drug effects , Action Potentials/physiology , Adrenergic beta-Agonists/pharmacology , Animals , Calcium Channel Blockers/pharmacology , Cardiac Catheterization , Cardiac Pacing, Artificial , Dogs , Equipment Design , Heart Conduction System/drug effects , Isoproterenol/pharmacology , Pacemaker, Artificial , Surface Properties , Verapamil/pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL
...