ABSTRACT
We examined the possibility that the common cold or afebrile upper respiratory tract infection might interfere with successful immunization in children who receive standard measles-mumps-rubella vaccine. Infants 15 to 18 months of age presenting at our well-child clinics for routine examination and immunizations were divided into two groups. Those infants with a history and physical findings of upper respiratory tract infection were compared with healthy control group infants who did not have upper respiratory tract infections, and who did not have a history of upper respiratory tract infection symptoms within the previous month. Both groups were studied for their serologic response to measles-mumps-rubella vaccination. Prevaccination serum samples were obtained prior to vaccine administration and postvaccination serum samples were obtained 6 to 8 weeks later. Measles antibody was measured in these serum samples by an indirect fluorescein-tagged antibody test. Ten (21%) of 47 infants with colds failed to develop measles antibody, while only one (2%) of 51 well infants failed to develop antibody. We conclude that infants with colds have a significant seroconversion failure rate associated with measles vaccine administration and that this may be the cause of some primary measles vaccine failures.
Subject(s)
Antibodies, Viral/analysis , Common Cold/complications , Measles Vaccine/administration & dosage , Measles virus/immunology , Measles/immunology , Mumps Vaccine/administration & dosage , Rubella Vaccine/administration & dosage , Common Cold/immunology , Drug Combinations , Female , Humans , Infant , Male , Measles/prevention & control , Measles-Mumps-Rubella Vaccine , Mumps/immunology , Mumps/prevention & control , Mumps virus/immunology , Rubella/immunology , Rubella/prevention & control , Rubella virus/immunologySubject(s)
Child Health Services , Preventive Health Services , Diagnosis , Female , Humans , Infant , Male , Military Medicine , United StatesABSTRACT
A child health assessment and screening program, staffed by volunteers, has evaluated approximately 5,000 children in a general pediatric clinic. A sample of 500 children was studied to determine characteristics of the population served, quality of the work of the volunteers and the number of new problems identified. Use of well-trained volunteers, provided with adequate supervision and follow-up physical examination of the children, identified many new problems at minimal cost and proved an effective means of expanding quality health care.