ABSTRACT
This paper reports on an investigation of the emotional adjustment by children and their parents to paediatric hospital admission for planned ear, nose and throat surgery. It discusses the first phase of that adjustment and the importance of the initial clinic consultation in shaping subsequent coping. The study developed directly from clinical practice and the findings are expected to feed back into practice. The assessment of an experimental approach to preparation, which tests the efficacy of a fresh appraisal of the way in which children and their parents are prepared for this elective surgery, is studied. While there are important findings that relate to all three phases of the experience, that is, the pre-admission, in-hospital and post-hospital adjustment phases, the impact of the initial clinic consultation alone is discussed in relation to the implications for practice arising from the study.
Subject(s)
Adaptation, Psychological , Child, Hospitalized/psychology , Parents/psychology , Patient Education as Topic/standards , Stress, Psychological/nursing , Child , Child, Preschool , Humans , Pediatric Nursing/methods , Stress, Psychological/diagnosisABSTRACT
236 patients with uncomplicated gonorrhoea were randomly allocated to receive either aztreonam or procaine penicillin plus probenecid. 115 patients (50 men and 65 women) with uncomplicated gonorrhoea were treated with 1 g aztreonam as a single intramuscular injection. The success rate among those who attended at least one follow up examination after treatment was 99%. The antibiotic was well tolerated and there were no side effects. The observed minimum inhibitory concentrations (MICs) of aztreonam in vitro were very much lower than obtainable serum concentrations. The penicillin treated patients who were evaluable showed a failure rate of 12.8%. We conclude that aztreonam is effective against Neisseria gonorrhoeae, including penicillinase-producing strains, both in vivo and in vitro.
Subject(s)
Aztreonam/therapeutic use , Gonorrhea/drug therapy , Penicillin G Procaine/therapeutic use , Penicillin G/therapeutic use , Probenecid/therapeutic use , Clinical Trials as Topic , Drug Therapy, Combination , Female , Humans , Male , Microbial Sensitivity Tests , Penicillin G Procaine/administration & dosage , Penicillinase/biosynthesis , Probenecid/administration & dosage , Random AllocationABSTRACT
A total of 225 female patients with uncomplicated gonorrhoea was treated at random with either a single intramuscular injection of 1 g aztreonam or with 2.4 mega units procaine penicillin intramuscularly plus 1 g probenacid orally. Patients were followed up at 1, 2 and 3 weeks for bacteriological tests. The success rate among 101 of 116 patients on aztreonam who attended at least 1 follow-up examination after treatment was 100%, including 11 cases with penicillinase-producing N. gonorrhoeae. The minimum inhibiting concentrations of aztreonam in vitro were very much lower than the serum concentration, all strains being sensitive at 0.5 micrograms/ml or less. In a comparative group of 109 women treated with penicillin, there were 11 failures (penicillinase-producing N. gonorrhoeae strains) in 98 women who were followed-up. Aztreonam was well tolerated and there were no side-effects.
Subject(s)
Aztreonam/therapeutic use , Gonorrhea/drug therapy , Aztreonam/administration & dosage , Drug Evaluation , Female , Humans , Injections, Intramuscular , Microbial Sensitivity Tests , Penicillin G/therapeutic use , Probenecid/therapeutic useABSTRACT
Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation.