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Aging Clin Exp Res ; 22(4): 303-7, 2010 Aug.
Article in English | MEDLINE | ID: mdl-19966538

ABSTRACT

This study was carried out to assess whether endothelial dysfunction, evaluated by flow-mediated dilation (FMD), is related to the occurrence of the Metabolic Syndrome (MetS) in old age. Eighty patients (25 men and 55 women), mean age 74.1±7.4 years (range 65-99 yrs) were studied. Information on all subjects, medical history and regular medications was obtained. Subjects underwent a clinical examination and laboratory tests. The presence of MetS was evaluated according to the revised NCEP-ATP III criteria. An ultrasound vascular examination (US) of the carotid and brachial arteries was performed in all patients. Intima-media thickness (IMT), presence of plaques (PL), endothelium-dependent (EDV) and -independent vasodilation (EIDV) were also evaluated. Patients were divided into two groups according to the presence/absence of MetS. Significant differences were found between MetS and non MetS patients in: EDV (p<0.01), EIDV (p<0.05) and Homeostatic model assessment index (HOMA) (p<0.02), but not in IMT or PL. MetS was significantly associated with FMD reduction (R 0.4, p<0.005) independently of all possible confounding factors other than EIDV, IMT and PL.


Subject(s)
Endothelium, Vascular/diagnostic imaging , Endothelium, Vascular/physiopathology , Metabolic Syndrome/diagnostic imaging , Metabolic Syndrome/physiopathology , Age Factors , Aged , Aged, 80 and over , Brachial Artery/diagnostic imaging , Brachial Artery/physiopathology , Cardiovascular Diseases/diagnostic imaging , Cardiovascular Diseases/etiology , Cardiovascular Diseases/physiopathology , Carotid Arteries/diagnostic imaging , Carotid Arteries/physiopathology , Female , Humans , Male , Metabolic Syndrome/complications , Risk Factors , Tunica Intima/diagnostic imaging , Tunica Media/diagnostic imaging , Ultrasonography , Vasodilation
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