ABSTRACT
Radioactive caesium nuclids were measured in follicular fluid and seminal plasma after the nuclear power station accident of Chernobyl. Immediately after the event (June - Aug. 86) both Cs 137 and Cs 134 were negative, with the exception of one sample. Increased levels of Cs 137 were found in the next three periods of measurement (Nov. 86 - Jan. 87), (June - Aug. 87), (March 88), with the highest results one year after the accident. Increased levels of Cs 134 were found only in the last two periods of measurement. In seminal plasma, both Cs 137 and Cs 134, were elevated in some samples. An influence on the results of IVF was not registered.
Subject(s)
Accidents , Cesium Radioisotopes/analysis , Nuclear Reactors , Ovarian Follicle/radiation effects , Power Plants , Radiation Injuries/diagnosis , Semen/radiation effects , Adult , Austria , Female , Fertilization in Vitro , Humans , Male , Soil Pollutants, Radioactive/analysis , UkraineABSTRACT
A 1-year-old boy with trisomy 18 (pter----q12) following a paternal balanced translocation revealed microcephaly, a pattern of minor dysmorphic features including upslanting narrow palpebral fissures, receding forehead, large nose and receding mandible, cryptorchidism, flexion contractures of fingers, a cardiac malformation and moderate mental retardation. While pure trisomy 18p generally goes along with a near-normal phenotype, additional trisomy of only a short segment of the proximal long arm 18 has a distinct negative influence on the phenotype, as seen in our proband.
Subject(s)
Abnormalities, Multiple/genetics , Chromosomes, Human, Pair 18 , Chromosomes, Human, Pair 21 , Translocation, Genetic , Trisomy , Face/abnormalities , Heart Defects, Congenital/etiology , Humans , Infant , Intellectual Disability/genetics , Male , Skull/abnormalitiesABSTRACT
Data of 67 patients, in whom 114 inseminated oocytes with morphological abnormalities were registered by means of light microscopy, were compared with those of a control group consisting of 69 patients where in vitro fertilization (IVF) proved successful. Significant correlations were found between certain parameters of the IVF attempt and the appearance of the described pathological changes in the oocytes. A significantly higher incidence of oocyte pathology was found with elevated progesterone and also LH values during the follicular phase. With a great number of follicles and in the case of small-sized follicles there were significantly more pathological ova--both degenerated and pathologically fertilized. A good oestrogen increase after ovulation induction with human chorionic gonadotrophin (HCG) was associated with fewer morphological abnormalities of the inseminated oocytes. When spermatozoa with lower total motility (less than or equal to 40%) or an increased percentage of pathological forms (greater than 60%) were used for IVF, significantly more pathological oocytes appeared. A pathological spermiogram was noticeably correlated with an increased occurrence of a solitary decayed nuclear structure of the mature ovum. The significance of these connections and a hypothesis of the development of the described nuclear structure are discussed.
