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Biochem Soc Trans ; 52(1): 89-97, 2024 Feb 28.
Article in English | MEDLINE | ID: mdl-38314621

ABSTRACT

RhoU and RhoV are members of the Rho family of small GTPases that comprise their own subfamily. RhoUV GTPases are classified as atypical due to the kinetics of their GTP/GDP binding cycles. They also possess unique N- and C-termini that regulate their subcellular localization and activity. RhoU and RhoV have been linked to cytoskeletal regulation, cell adhesion, and cell migration. They each exhibit distinct expression patterns during embryonic development and diseases such as cancer metastasis, suggesting they have specialized functions. In this review, we will discuss the known functions of RhoU and RhoV, with a focus on their roles in early development, organogenesis, and disease.


Subject(s)
GTP-Binding Proteins , rho GTP-Binding Proteins , GTP-Binding Proteins/metabolism , rho GTP-Binding Proteins/metabolism , Signal Transduction , Cell Adhesion
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