Peak skin and eye lens radiation dose from brain perfusion CT: CTDIvol and Monte Carlo based estimations.

PURPOSE: To quantify the eye lens, peak skin and brain doses associated with head CT perfusion exam by means of thermoluminescent dosimeters (TLDs) measurements in a cadaver and compare them to Monte Carlo (MC) dose estimations as well as to the CTDIvol. METHOD: 18 TLDs were inserted in the brain, skin, and eye lenses of a female cadaver head, who underwent a CT brain perfusion scan using a Siemens Definition Flash. The table-toggling protocol used 80 kVp, 200 mAs, 32 × 1.2 mm collimation and 30 sequences. From the CT images, a voxel model was created. Doses were calculated with a MC framework (EGSnrc) and compared to TLD measurements. TLD measurements were also compared to the displayed CTDIvol. RESULTS: The average measured doses were: 185 mGy for the eyes lenses, 107 mGy for the skin, 172 mGy for the brain and 273 mGy for the peak skin. The reported CTDIvol of 259 mGy overestimated the averaged organ doses but not the peak skin dose. MC estimated organ doses were 147 mGy for the eyes (average), 104 mGy for the skin and 178 mGy for the brain (-20 %, -3% and 4% difference respect to the TLDs measurements, respectively). CONCLUSIONS: CTDIvol remains a conservative metric for average brain, skin and eyes lenses doses. For accurate eye lens and skin dose estimates MC simulations can be used. CTDIvol should be used with caution as it was of the same order of magnitude as the peak skin dose for this protocol and this particular CT scanner.

Rotating and translating anthropomorphic head voxel models to establish an horizontal Frankfort plane for dental CBCT Monte Carlo simulations: a dose comparison study.

In order to carry out Monte Carlo (MC) dosimetry studies, voxel phantoms, modeling human anatomy, and organ-based segmentation of CT image data sets are applied to simulation frameworks. The resulting voxel phantoms preserve patient CT acquisition geometry; in the case of head voxel models built upon head CT images, the head support with which CT scanners are equipped introduces an inclination to the head, and hence to the head voxel model. In dental cone beam CT (CBCT) imaging, patients are always positioned in such a way that the Frankfort line is horizontal, implying that there is no head inclination. The orientation of the head is important, as it influences the distance of critical radiosensitive organs like the thyroid and the esophagus from the x-ray tube. This work aims to propose a procedure to adjust head voxel phantom orientation, and to investigate the impact of head inclination on organ doses in dental CBCT MC dosimetry studies. The female adult ICRP, and three in-house-built paediatric voxel phantoms were in this study. An EGSnrc MC framework was employed to simulate two commonly used protocols; a Morita Accuitomo 170 dental CBCT scanner (FOVs: 60 × 60 mm2 and 80 × 80 mm2, standard resolution), and a 3D Teeth protocol (FOV: 100 × 90 mm2) in a Planmeca Promax 3D MAX scanner. Result analysis revealed large absorbed organ dose differences in radiosensitive organs between the original and the geometrically corrected voxel models of this study, ranging from -45.6% to 39.3%. Therefore, accurate dental CBCT MC dose calculations require geometrical adjustments to be applied to head voxel models.

CUSTOMISATION OF A MONTE CARLO DOSIMETRY TOOL FOR DENTAL CONE-BEAM CT SYSTEMS.

A versatile EGSnrc Monte Carlo (MC) framework, initially designed to explicitly simulate X-ray tubes and record the output data into phase space data files, was modified towards dental cone-beam computed tomography (CBCT) dosimetric applications by introducing equivalent sources. Half value layer (HVL) measurements were conducted to specify protocol-specific energy spectra. Air kerma measurements were carried out with an ionisation chamber positioned against the X-ray tube to obtain the total filtration attenuation characteristics. The framework is applicable to bowtie and non-bowtie inherent filtrations, and it accounts for the anode heel effect and the total filtration of the tube housing. The code was adjusted to the Promax 3D Max (Planmeca, Helsinki, Finland) dental CBCT scanner. For each clinical protocol, calibration factors were produced to allow absolute MC dose calculations. The framework was validated by comparing MC calculated doses and measured doses in a cylindrical water phantom. Validation results demonstrate the reliability of the framework for dental CBCT dosimetry purposes.

Accuracy of CT dose monitor values: a multicentric study.

Four hundred and ninety-five adult patients in 16 medical centres participated in this study aiming to investigate the congruence between the volume CT dose index (CTDIvol) monitor values and measured ones during common CT procedures, performed by 20 systems. Tube output CTDIair measurements were carried out on single and multislice scanners for any kV, slice thickness, mA and FOV combination used. The maximum/minimum ratio of measured CTDIvol values found to be 3.1, 3.5, 7.4, 7.5, 4.2, 11.3 and 5.5 for head base, head cerebrum, thorax, abdomen, pelvis, cervical spine and lumbar spine protocols, respectively. The mean divergence between the measured and displayed CTDIvol values was 4.2, 3.5, -1.0, 2.7, 4.9, -3.9 and -2.8 % for protocols as mentioned above, respectively. From the perspective of the number of detector rows of the scanners, the mean divergence was -6.7, -6.0, 0.8, -1.1, -0.4, -1.9, -5.3, 5.2 and 10.1 % for single, dual, 4, 6, 16, 24, 64, 128 and dual source 256-slice systems, respectively.

Mobile health to improve tuberculosis care and control: a call worth making.

The use of mobile phones has substantially increased throughout the world over the last decade. This has opened up opportunities for the integration of mobile phones as health intervention tools in many aspects of health care, including prevention, diagnosis, data collection, treatment and adherence monitoring and surveillance. Several applications have been explored in human immunodeficiency virus care. The field of tuberculosis (TB) has not exploited the potential of mobile health (m-health) to the same extent, although the opportunities have been recognized. A number of proof-of-concept and pilot studies have been published on m-health in TB care, and an even larger number of studies are available in the grey literature. This article summarizes publications and recent developments at the intersection of TB care and m-health. We show that more rigorous studies evaluating different applications and implementation strategies are needed to establish an evidence base that serves to inform policy and decision making. We outline further areas of research that should be addressed and potential challenges that lie ahead if m-health applications are to enhance the accessibility and quality of TB care.

The effect of a combined tube current modulation system on dose delivered to patients undergoing thoracic and abdominal CT with a 128-slice scanner.

Combined tube current modulation techniques (such as Care Dose4D used in this study) during computed tomography (CT) procedures bring together the benefits of the angular and z-axis modulation techniques, measuring X-ray attenuation profile in the z-axis together with the data from the perpendicular x-y direction with a sophisticated algorithm. The purpose of this study was to investigate the radiation dose, in terms of computed tomography dose index (CTDI(vol)), delivered to patients during thoracic and abdominal CT using this technique and compare it with the corresponding CTDI(vol) of the fixed tube current CT technique. The results revealed a 5-32% dose reduction for chest CT and a dose reduction of 7.6-60% for the three-sequence abdominal CT scan of normal and overweight patients. In the case of obese patients a 15.4-18.7% dose increase for chest CT and a (-1.5) - (26.3)% dose increase for the three-stage abdominal examinations for females and males, respectively, was revealed.

The value of corneal transplantation in reducing blindness.

PURPOSE: To analyse the role of keratoplasty in reducing world blindness due to corneal diseases. METHODS: Review of published literature. We collected and analysed articles published in the English language literature related to the prevalence and causes of blindness in different parts of the world, causes of corneal blindness, and outcome of corneal transplantation for various corneal diseases. RESULTS: A total of 80% of the world's blind live in developing countries. Retinal diseases are the most important causes of blindness (40-54%) in established economy nations while cataract (44-60%) and corneal diseases (8-25%) are the most common causes of blindness in countries with less developed economies. Keratitis during childhood, trauma, and keratitis during adulthood resulting in a vascularized corneal scar and adherent leucoma are the most frequent causes of corneal blindness in developing countries. Corneal diseases are responsible for 20% of childhood blindness. Nearly 80% of all corneal blindness is avoidable. The outcome of keratoplasty for vascularized corneal scar and adherent leucoma is unsatisfactory, necessitating repeat surgery in a high proportion of these cases. Other barriers for keratoplasty in these nations are suboptimal eye banking, lack of trained human resources, and infrastructure. CONCLUSIONS: Since the developing world carries most of the load of corneal blindness and the major causes of corneal blindness are corneal scar and active keratitis, development of corneal transplantation services need a comprehensive approach encompassing medical standards in eye banking, training of cornea specialists and eye banking personnel and exposure of ophthalmologists to care of corneal transplants for better follow-up care. However, concerted efforts should be made to develop and implement prevention strategies since most corneal blindness is preventable.