Impact of a pharmacist-driven protocol to decrease proton pump inhibitor use in non-intensive care hospitalized adults.

PURPOSE: Results of a pharmacist-driven protocol to decrease proton pump inhibitor (PPI) use in non-intensive care unit (ICU) hospitalized adults are presented. METHODS: This concurrent preintervention and postintervention study included subjects at least 18 years of age receiving PPIs while hospitalized in general medical or surgical beds. Patients were identified for inclusion in the postintervention group using a daily list of hospitalized patients with active PPI orders. A pharmacist evaluated these subjects for PPI appropriateness, and then recommended discontinuing or changing PPIs to histamine H2-receptor antagonists. Per protocol, the pharmacist could change PPIs to H2-antagonists if prescribers did not respond to recommendations. Preintervention group patients were gathered retrospectively and treated as the retrospective control group. Patients were excluded if they had cumulative ICU or ICU step-down stays of at least two days, had predefined appropriate indications for PPIs, or were not evaluated within one day of PPI orders. The primary outcome was the rate of PPI use. Secondary objectives included rates of prescriber acceptance of pharmacist recommendations and hospital-onset Clostridium difficile infections (HO-CDI). RESULTS: PPIs were discontinued in 66.0% (n = 62) of postintervention group patients compared to 41.1% (n = 39) of the preintervention group (absolute risk reduction, 24.9%; p = 0.001). In the postintervention group, 31.9% (n = 30) of recommendations were accepted, whereas 11.7% (n = 11) were rejected. No subjects in either group were diagnosed with HO-CDI during the study period. CONCLUSION: The pharmacist-driven protocol described in this study decreased PPI use in non-ICU hospitalized adults.

Impact of Clinical Pharmacist Interventions on 30-Day Readmission Rate in Hospitalized Patients With Acute Myocardial Infarction.

Background: Limited literature exists on the positive impact of pharmacists specifically on hospital readmission of patients with acute myocardial infarction (AMI). Objective: To evaluate the overall effect of clinical pharmacist interventions on preventing hospital readmissions and improving the health of patients with AMI. Secondary objectives include identifying trends in the demographic characteristics of AMI patients, identifying potential barriers to adherence, and assessing the average time spent by a pharmacist counseling AMI patients. Methods: This prospective, nonrandomized, single-center study was approved by the institutional review board. The hospital's 30-day AMI readmission rate prior to study initiation was used as the control group. An AMI report was generated daily to identify patients admitted to the hospital diagnosed with either non-ST or ST segment elevation myocardial infarction. The clinical pharmacist then counseled the included patient prior to discharge and provided a follow-up phone call 48 hours after discharge. The primary outcome was the all-cause 30-day readmission rate for AMI patients. Results: Out of 71 patients screened, 50 patients were included in the study. Only 3 of the 50 patients included were readmitted (6.0%). The prestudy rate from October 2012 to October 2013 was 11.6%, or 58 readmissions out of 498 AMI admissions. Although the study group was much smaller in size, a 6% readmission rate is encouraging and offers potential for a future intervention. Conclusion: Clinical pharmacist services for AMI patients, including counseling, interventions, and a follow-up phone call after discharge, may benefit decreasing the 30-day AMI readmission rate; however, further studies are needed.