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Vestn Akad Med Nauk SSSR ; (6): 40-4, 1990.
Article in Russian | MEDLINE | ID: mdl-2220037

ABSTRACT

The possibility of using ectericide, having antibacterial, detergent, antioxidative, and reparative effects, as a dispersion medium for liposome production has been studied. Its application allows for elaboration of a simplified liposome production technique simultaneously imparting them stability against oxidation, heating, and pH changes. A technology to produce multivesicular liposomes with ectericide++, containing rifampicin in the membranous envelope and gentamicin in the inner volume, has been developed. Liposomal antibiotics proved to be effective in clinical trials.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Anti-Infective Agents, Local/chemical synthesis , Bacterial Infections/drug therapy , Drug Compounding/methods , Liposomes/chemical synthesis , Technology, Pharmaceutical/methods , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents, Local/pharmacology , Anti-Infective Agents, Local/therapeutic use , Bacteria/drug effects , Drug Carriers , Drug Evaluation, Preclinical , Drug Synergism , Humans , In Vitro Techniques , Liposomes/therapeutic use , Tissue Extracts
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