Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
2.
Ter Arkh ; 73(7): 34-40, 2001.
Article in Russian | MEDLINE | ID: mdl-11523406

ABSTRACT

AIM: To compare the capacity of ionophore for calcium ions and growth factors (granulocytic-macrophagal colony-stimulating factor, interleukin-4, tumor necrosis factor) to induce costimulatory molecules on the surface of blast cells from patients with acute myeloid leukemia (AML). MATERIALS AND METHODS: The study was carried out in 6 patients with primary and resistant AML using culturing and flow cytometry. RESULTS: Blast cells obtained from patients during diagnosis of AML and after drug therapy of resistant AML acquire the dendrite phenotype under the effects of growth factors and Ca ion ionophore. CONCLUSION: Calcium metabolism modulators can be used for creation of antileukemic vaccines.


Subject(s)
Antigen-Presenting Cells , Immunotherapy , Leukemia, Myeloid/therapy , Acute Disease , Adult , Calcium/pharmacology , Cells, Cultured , Dendritic Cells/drug effects , Dendritic Cells/immunology , Female , Flow Cytometry , Growth Substances/pharmacology , Humans , Immunophenotyping , Ionophores , Ions , Leukemia, Myeloid/immunology , Leukemia, Myeloid/pathology , Male , Middle Aged , T-Lymphocytes/immunology
SELECTION OF CITATIONS
SEARCH DETAIL
...