[The role of immunomodulating therapy in the treatment and prevention of exacerbations of chronic cystitis].

The article presents the results of the examination and treatment of 60 women with chronic cystitis aged 20 to 80 years. The mean disease duration was 4,9 years (ranged from 6 months to 40 years). Immunomodulator Tilorone was included in the complex therapy of 30 patients of the main group. Besides the standard examination, immunological studies, including the definition of netrophil phagocytic rates in the patients were performed. It was revealed that the inclusion of immunomodulator in the treatment regimen of exacerbations of chronic cystitis contributes to an increase of index of activation of neutrophil phagocytic reserve, significant reduction in the frequency of exacerbations of the disease after the basic and preventive courses of treatment.

[Lavomax treatment of chronic cystitis].

Lavomax--a synthetic fluorenon compound and a classic oral low-molecular interferon inductor--was for the first time used in combined treatment of chronic recurrent cystitis. We compared clinico-immunological indices in the treatment of exacerbations of chronic cystitis in females given lavomax and treated without it. The course of treatment consisted of 10 tablets 0.125 g each, a prophylactic course--1 tablet a week for 6 weeks. A total of 60 females aged 19-80 years entered the trial. In women given lavomax it elevated leukocyte production of alpha and gamma interferon: on treatment day 17 interferon alpha rose to 31.25 pg/ml, gamma--to 27.29 pg/ml (double baseline level). Nine weeks since the start of the treatment the above indices lowered but stayed above normal values (25.84 and 24.4 pg/ml, 23.05 and 16.39 pg/ml, respectively). As an adjuvant, lavomax promoted faster elimination of cystitis symptoms: complaints disappeared in 50% patients while in the control group only in 17%). Eradication of the bacteria was achieved in 66.7% patients. In the controls it was 2 times less. Adjuvant use of lavomax in therapy of chronic cystitis reduced frequency of cystitis recurrences.