[Application of interrupted normobaric hypoxia stimulation on healthy people]. / Primenenie preryvistoi normobaricheskoi gipoksicheskoi stimuliatsii u prakticheski zdorovykh liudei.

The INHS application with the practically healthy (sane) people gained the extraordinary widening. This method was theoretically grounded by M.M. Sirotinin's and his followers' works. It is used by physiologists, therapeutists surgeons and sports' doctors in many countries of the world. Up to now a days more than 350 hundreds of people feel the positive influence of the INHS. There are the contemporary literature review, the INHS application for the sports results and olympic achievements augmentation, the illnesses prevention, the population health scale increase regarded. The advantages and disadvantages of different variants of INH, their influence on the breathing parameters, the hemopoiesis and the regeneration processes are examined. The INH usage in order to decrease the biological age and to increase the human being life quality is rather perspective.

[The prospects for the use of a method of intermittent normobaric hypoxic stimulation (hypoxitherapy) in medical practice]. / Perspektivy primeneniia metoda preryvistoi normobaricheskoi gipoksicheskoi stimuliatsii (gipoksiterapii) v meditsinskoi praktike.

Hypoxitherapy proposed by Russian researchers promotes a 2-3-fold decrease in morbidity of poor-health subjects (high risk groups). As shown by the experience gained in the medical department of the Moskvich car corporation hypoxitherapy provides enhancement of the human resistance to extreme ecological conditions responsible for high mortality of population in the Russian Federation. The information on the production of special devices, hypoxicators, for creation of hypoxic mixtures (mountain air) is given. Large-scale application of hypoxitherapy for prevention, treatment and rehabilitation seems most effective in the conditions of sanatoria.

[Manifestation of oxygen effect during normobaric hypoxic hypoxia in the intrauterine and postnatal developmental periods]. / Proiavlenie kislorodnogo éffekta v usloviiakh normobaricheskoi gipoksicheskoi gipoksii vo vnutriutrobnyi i postnatalnyi periody razvitiia.

The experiments on rats have shown that hypoxic gas mixture containing 10% of oxygen and 90% of nitrogen (HGM-10) under normobaric conditions exerts a highly reliable radioprotective effect on progeny when 11-day pregnant animals are exposed to total irradiation (60Co, 20 Gy). As distinct from the known radioprotector, mexamine, (5-methoxytryptamine), HGM-10 has a pronounced radioprotective effect during the first days (1-5) after birth. Radioresistance of new-born rats correlates with the level of pO2 in the tissues which progressively decreases with respiration of HGM-10 and remains unchanged after mexamine (10 mg/kg) introduction.

[Effect of intermittent normobaric hypoxic activity on the development of acute radiation disease]. / Vliianie preryvistogo normobaricheskogo gipoksicheskogo vozdeistviia na razvitie ostroi luchevoi bolezni.

The experiments on 260 male mice of colony SHK, 352 mongrel rats and 20 Wistar rats were carried out to study the ability of using the normobaric hypoxic stimulation method for acute radiation sickness. Hypoxic stimulation using gas mixture with 10% of oxygen and 90% of nitrogen was conducted for two weeks after irradiation for 30 min. every day. It is shown that under influence of ionizing radiation (7 and 5.5 Gy) the postradiation hypoxic action increased the 30-day survival rate of mice, reduced disturbances of the qualitative composition of leukocytes in peripheric blood, promoted more rapid restoration of thromboelastography indices and caused no reliable changes in the postradial content of albumin and creatinine in blood.

[A decrease in the toxic action of x-ray contrast media using normobaric hypoxic stimulation]. / Snizhenie toksicheskogo deistviia rentgenokontrastnykh sredstv s pomoshch'iu normobaricheskoi gipoksicheskoi stimuliatsii.

A preliminary 30-min action of normobaric hypoxia was found to increase the duration of life of mice treated with lethal doses of billignost, triombrast and verographin. The severity of triombrast-induced pulmonary edema in rats was demonstrated.

[The effect of normobaric hypoxic stimulation on the aggregation properties of blood cells in an irradiated host]. / Vliianie normobaricheskoi gipoksicheskoi stimuliatsii na aggregatsionnye svoistva kletok krovi obluchennogo organizma.

The influence of a short-term intermittent stimulation by hypoxia on the aggregative properties of platelets and erythrocytes of irradiated body has been investigated. The results show a favourable effect of hypoxic stimulation on some platelet aggregation indices.

[Influence of hypoxia on the effects of ethanol and acetaldehyde]. / Vliianie gipoksii na deistvie étanola i atsetal'degida.

During experiments on male SHK mice it was established that a preliminary normobaric normocapnic hypoxic stimulation (30-minute inhalation of a gas mixture containing 10% of oxygen) increased the animal organism resistance to toxic effects of ethanol and its metabolite acetaldehyde.

[Use of cell cultures in the pharmacological experiment]. / Ispol'zovanie kletochnykh kul'tur v farmakologicheskom éksperimente.

A statistical method is proposed which makes it possible to evaluate quantitatively the significance and reliability of the effects of pharmacological agents during their study on cell cultures using a little scope of material samples. The method substantially reduces the expenditures of the researcher's time and labour.

[Effect of gaseous hypoxic mixture GHM-10 on the intestinal death of Wistar rats and Na+,K+-ATPase activity of the plasma membrane of the small intestine mucosa after irradiation]. / Vliianie gazovoi gipoksicheskoi smesi GGS-10 na kishechnuiu gibel' krys Vistar i aktivnost' NA+,K+-ATFazy plazmaticheskikh membran slizistoi tonkogo kishechnika posle oblucheniia.

It was shown that gas hypoxic mixture containing O2 (10%) and N2 (90%) significantly decreases "intestinal" death of Wistar rats on the 5th day following irradiation and normalizes Na+,K+-ATPase activity of the small intestine mucosa plasma membranes.

[Modification of the radiation injury of hematopoiesis in rats using the gaseous hypoxic mixture GHM-10]. / Modifikatsiia luchevogo porazheniia krovetvoreniia u krys s pomoshch'iu gazovoi gipoksicheskoi smesi GGS-10.

In experiments on Wistar rats it was shown that gas hypoxic mixture containing O2 (10%) and N2 (90%) had a radioprotective action with regard to the survival rate for 30 days and to the haemopoietic system status. The application of gas hypoxic mixture reduced the postirradiation cytopenia in the blood and lowered the degree of the bone marrow depletion by the 3d day following irradiation; DMF was 1.25 as determined by total bone marrow cellularity.

[The immediate and late results of protecting the patient's normal tissues by using the gas hypoxic mixture GHM-10 in the radiation therapy of breast cancer]. / Neposredstvennye i otdalennye rezul'taty zashchity normal'nykh tkanei patsienta s pomoshch'iu gazovoi gipoksicheskoi smesi GGS-10 pri luchevoi terapii raka molochnoi zhelezy.

The effect of inhalation of gaseous hypoxic mixture GHM-10 (oxygen--10 +/- 1.0 and nitrogen--90.0 +/- 1.0%) on radiation response of normal tissues was studied in 184 breast cancer patients. The mixture was administered to 120 patients while 74 controls received a standard course of radiotherapy. Administration of the mixture improved normal tissue resistance to radiotherapy for breast cancer and was followed by lower incidence of long-term radiation injury, lower frequency and shorter duration of general vegetative reactions to radiation.

[Increased body resistance to the toxic action of cyclophosphane through the use of short-term hypoxic hypoxia]. / Povyshenie rezistentnosti organizma k toksicheskomu deistviiu tsiklofosfana s pomoshch'iu kratkovremennoi gipoksicheskoi gipoksii.

Experiments were carried out on 535 SHK albino male mice weighing 24.0 +/- 4.0 g to study the modifying effect of gas hypoxic mixture containing 10.0 +/- 1.0% O2 and 90.0 +/- 1.0% N2 (GHM-10) on cyclophosphane toxicity after intraperitoneal injection of 800, 1000, 1200, 1400, 1600, 1800, and 2000 mg/kg. Before the injection, the animals were kept in a hypoxic medium for 30 min, which reduced mortality rate. It is found that human organism can endure GHM-10 quite well.

[Effect of whole-body irradiation of females on pregnancy and postnatal development of the offspring]. / Vliianie obshchego gamma-oblucheniia samok na beremennost' i postnatal'noe razvitie potomstva.

In 218 primigravida rats of Wistar strain with body mass 200-250 g radiosensitivity during the whole period of pregnancy has been studied after a single total gamma-radiation with 60Co given in LD50 2.0 Gy. The multifactor analysis includes: dynamics of the body mass of the pregnant rats, ability to implantation and pregnancy, duration of pregnancy, number of births that failed, body mass loss during delivery, death of the embryos during the antenatal period, number of viable offsprings, dynamics of body mass in the offsprings and their viability during 30 days after birth, time for covering with fur and eyes opening, developmental anomalies etc. Quantitative and qualitative postradiative disorders of the intrauterine and postnatal development of the offsprings are described. The most sensitive days of pregnancy are revealed (the 1st--3d and the 9th--11th days).

[Radioprotective effectiveness of gas hypoxic mixture GHM-10 in experiments on dogs]. / Radiozashchitnaia éffektivnost' gazovoi gipoksichesko smesi GGS-10 v opytakh na sobakakh.

In experiments on 128 dogs (males and females) weighing 7-24 kg it was demonstrated that inhalation of gas hypoxic mixture containing O2 (10%) and N2 (90%) decreased significantly the level of PO2 in radiosensitive tissues and exerted a radioprotective effect on the exposed animals (60Co, doses of 2.8, 3.5-3.8 and 4.2 Gy, DMF = 1.3). At a dose of 8 Gy the average life of animals increased from 6.2 +/- 0.8 days (control) up to 9.3 +/- 1.1 days after the application of GHM -10.

[Radioprotective action of a gas hypoxic mixture GHM-10 in multiple irradiations of rat and human skin]. / Izuchenie radiozashchitnogo deistviia gazovoi gipoksicheskoi smesi GGS-10 pri mnogokratnom obluchenii kozhnykh pokrovov krys i cheloveka.

Gas hypoxic mixture (GHM-10) decreased significantly the occurrence and duration of radioepidermitis after local therapeutic fractionated irradiation of Wistar rat skin with a cumulative dose of 66 Gy. In patients subjected to radiation therapy and protected with GHM-10 erythema and epidermitis developed at a much higher cumulative dose than in the controls. With erythema dose modifying coefficient was 1.38 +/- 0.06.

[Modification of the intestinal syndrome using a hypoxic gas mixture under different conditions of animal irradiation]. / Modifitsirovanie kishechnogo sindroma s pomoshch'iu gazovoi gipoksicheskoi smesi v razlichnykh usloviiakh oblucheniia zhivotnykh.

In experiments on 1152 CBA mice and SHK colony and on 1180 Wistar rats it was demonstrated that a gas hypoxic mixture containing oxygen (10%) and nitrogen (90%) (GHM-10) reduced the intestinal syndrome of the acute radiation sickness in animals exposed to ionizing radiation at rest, during physical exercises, after radiation sickness endured earlier, after exposure to SHF, after fractionated irradiation, and after radiation-and-thermal damage.