ABSTRACT
In the German Federal Republic, the incidence of urolithiasis is 0.54% and the prevalence is 4%. Calcium oxalate stones are to be expected in over 60% of the cases. Pathogenetic factors are discussed. It is demonstrated that the overconsumption of chocolate, rhubarb and spinach brings about risk situations for stone formation, while asparagus and tomatoes present no risk. The increased animal protein and alcohol intake may be the most important reasons for the accumulations of calcium oxalate stones. Beside the minimum investigation programme it is demonstrated by examples that recurrent stone formers need an extended investigation to find out more about the pathogenesis, in order to determine an effective treatment or to prevent recurrences.
Subject(s)
Urinary Calculi , Adult , Age Factors , Aged , Calcium Oxalate/metabolism , Female , Germany, West , Humans , Male , Middle Aged , Urinary Calculi/diagnosis , Urinary Calculi/epidemiology , Urinary Calculi/etiology , Urinary Calculi/metabolismSubject(s)
Beverages , Drug Combinations , Plant Extracts , Plants, Medicinal , Urinary Calculi/prevention & control , Adult , Calcium Oxalate , Female , Humans , Male , Middle Aged , RecurrenceABSTRACT
While adhering to a standardized intake of food and liquids the effect of Solubitrat medicinal tea was tested under hospital conditions on the important serum parameters for urinary calculus formation and on the excretion of lithogenic and inhibitory substances in the urine. No significant differences were found in the serum parameters and in the 24 hr urine between the control group and the trial group. Observation of the day and night rhythm in the urine of the test group showed a prevention of the otherwise normal excretion peaks of most parameters at night, in particular the Ca concentration showing a significant flattening. Solubitrat medicinal tea consequently reduces the risk of urinary calculus formation and can be recommended without restriction for the fluid supply in the prophylaxis of urinary calculus.
Subject(s)
Beverages , Plant Extracts/therapeutic use , Plants, Medicinal , Urinary Calculi/prevention & control , Adult , Calcium/urine , Female , Humans , Male , Middle Aged , Oxalates/urine , Urinary Calculi/urineABSTRACT
The action of a benzbromarone citrate combination (Harolan) in the prevention of uric acid and oxalate stones was studied in 21 patients suffering from calcium oxalate stones. The investigation was carried out under standard diet to eliminate possible variabilities in the excretion of lithogenous and inhibitory substances due to individual eating habits. Under Harolan a significant reduction in the serum uric acid level as well as simultaneous elevation of the urine pH-value could be achieved, the latter resulting in improved solubility of uric acid, the excretion of which is increased during the first days of treatment. Neither in 24 hour urine nor in the circadian rhythm was the solubility curve for uric acid exceeded during the test period. Side-effects were not observed.
