ABSTRACT
A 23-year-old man with AIDS developed a lesion with the clinical characteristics of an ectopic geographic tongue in the lower lip, near the right commissure.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Glossitis, Benign Migratory/complications , Lip Diseases/complications , Adult , Epithelium/pathology , Glossitis, Benign Migratory/pathology , Humans , Lip Diseases/pathology , MaleABSTRACT
We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein-negative by immunoperoxidase (PAP method). One patient showed comma-shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self-limiting condition that requires no treatment.
Subject(s)
Histiocytosis/pathology , Skin Diseases/pathology , Cheek , Child , Child, Preschool , Diagnosis, Differential , Facial Dermatoses/diagnosis , Facial Dermatoses/pathology , Histiocytosis/diagnosis , Histiocytosis, Langerhans-Cell/diagnosis , Humans , Skin Diseases/diagnosis , Skin Neoplasms/diagnosis , Xanthogranuloma, Juvenile/diagnosisABSTRACT
A multi-institutional double blind study was performed in 66 patients in order to evaluate the action of human leukocyte interferon, type alpha (IFN) in lesions produced by herpes simplex virus. Lesions were localized in genital area in 34 cases and in facial area in 32 of them. From the total, 38 patients were treated with 7,000 Ul/gm. of interferon ointment and 28 with carbowax 4,000 as placebo. The symptoms pain, ardor, itching and paresthesia were evaluated asking to patients. Erythema, vesicles, crust, scale adenopathy were objectivated. Signs and symptoms were controlled on days 3 and 7 of treatment. In 42 patients, lesions specimens were taken for virus isolation. In 23 of them, cytopathic effect was detected (54.76%). Results showed a rapid relief from pain (p less than 0.05), ardor (p less than 0.01) and paresthesia (p less than 0.001) and also accelerated healing of vesicles in patients treated with interferon. Tendency to reduce the total time of the disease in those patients treated with IFN was observed.
Subject(s)
Herpes Simplex/therapy , Interferon Type I/therapeutic use , Administration, Topical , Adolescent , Adult , Aged , Argentina , Child , Child, Preschool , Double-Blind Method , Drug Evaluation , Female , Humans , Infant , Interferon Type I/administration & dosage , Male , Middle Aged , Multicenter Studies as Topic , OintmentsABSTRACT
A case of cloacogenic carcinoma with cutaneous metastases in a 74 year old man is reported. The patient presented with a six months history of two polyps of the lowest portion of the anal canal. Physical examination of the inguino-scrotal area revealed a 5 X 7 cm. hard infiltrative plaque with three ulcero-vegetative scars. Histologic examination of both polyps revealed two of the four cytologic patterns described in this neoplasm. One polyp showed undifferentiated cells, type IV and second one, type II differentiated. The biopsy of the cutaneous metastases showed dermal infiltrative clusters of the cytologic type II differentiated epidermal cells. Treatment with radiotherapy and chemotherapy was ineffective. Cloacogenic carcinoma of the canal anal is a transitional cells neoplasm believed to arise from vestigial remnants of cloacal origin. Metastases occurred in 19% of cases but cutaneous colonization develops exceptionally.
Subject(s)
Anus Neoplasms/pathology , Carcinoma, Transitional Cell/secondary , Skin Neoplasms/secondary , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Anus Neoplasms/radiotherapy , Carcinoma, Transitional Cell/drug therapy , Carcinoma, Transitional Cell/radiotherapy , Fluorouracil/therapeutic use , Groin , Humans , Male , Skin Neoplasms/drug therapy , Vinblastine/therapeutic useABSTRACT
A clinical, histopathological and immunological study was carried on a series of seven patients of Familial Benign Chronic Pemphigus (FBCP). This condition is characterized by recurrent small blisters, mainly, on intertriginous areas and on the sides of the neck, that become wet and crusted rapidly. They are generally sharply marginated and Nikolsky's sign is often positive. The lesions appear spontaneously and may be precipitated by warm, humid environment, mechanical trauma, radiations, bacterial or mycotic infection. Healing occurs with residual non scarring hyperpigmentation. Histopathologically, the epidermal alteration respond to a primary acantholytic mechanism. Ultramicroscopic studies have suggested an alteration on the desmosome-tonofilament complex. Comparatively with Pemphigus, another acantholytic disease in which immunological pathogenesis is strongly suspected, only few reports are referred to immunological studies in FBCP. In the present paper, a direct immunofluorescent study on spontaneous and provoked blisters was made in order to investigate deposits of immunoglobulins and complement. Indirect IF was performed with sera of teh patients for detection of circulating antibodies. Two cases were also sensitized with erythrocytic antigen. The immunological response to this substance was evaluated. The clinical and histopathological findings of the present series, are similar with previous descriptions. The immunofluorescent studies do not provide evidence of antibodies to epidermal intercellular space, like Pemphigus.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Pemphigus/genetics , Adult , Aged , Antibodies/analysis , Child , Chronic Disease , Female , Hemagglutinins/analysis , Humans , Male , Middle Aged , Pemphigus/immunology , Pemphigus/pathologyABSTRACT
Five cases of aplasia cutis congenita are presented, three of them with the classic localization of the scalp. The fourth case involves the lower extremities and the fifth, the trunk. The malformations associated to each case are described. A review of the existing literature and of possible etiologies is done.
Subject(s)
Skin Abnormalities , Biopsy , Female , Humans , Infant, Newborn , Male , Scalp/abnormalities , Skin/pathology , Skin Ulcer/congenitalABSTRACT
A patient with renal transplant developed muco-cutaneous Kaposi's sarcoma. The tumors appeared within a mont after surgery, while receiving daily 240 mgr . of methylprednisone and 150 mgr . of azathioprine. She received superficial radiotherapy ( Cesio 137) on her cutaneous lesions and the nasal tumor was removed with Laser radiation CO2 obtaining a favorable a response. Possible etiopathogenic mechanisms are mentioned. Clinical, epidemiologic, therapeutic and prognosis features of these transplanted subjects are discussed. Publications of other similar cases are reviewed.
Subject(s)
Kidney Transplantation , Neoplasms, Multiple Primary/etiology , Nose Neoplasms/etiology , Sarcoma, Kaposi/etiology , Skin Neoplasms/etiology , Adult , Female , Humans , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/therapy , Nose Neoplasms/surgery , Postoperative Complications , Radiotherapy Dosage , Sarcoma, Kaposi/pathology , Sarcoma, Kaposi/radiotherapy , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapyABSTRACT
Es una enfermedad que se hereda en forma autosomica dominante con alta penetrancia caracterizada por la aparicion unica o sucesiva de multiples lentigos. Se cominican dos nuevos casos, uno de ellos en un nino de 12 anos de edad, de raza amarilla con trastornos electrocardiograficos, hipertelorismo e hipospadia y el otro se trata de una mujer de 24 anos que asociaba hipertelorismo, hipoacusia, escoliosis dorsal, sindactilia y disostosis mandibular de Franchesqueti. Se efectua una revision bibliografica enumerando las patologias asociadas y se realizan comentarios etiopatogenicos. Los autores consideran la utilidad practica del acrostico Leopard para la sistematizacion del estudio de estos enfermos
Subject(s)
Child , Humans , Male , NevusABSTRACT
Es una enfermedad que se hereda en forma autosomica dominante con alta penetrancia caracterizada por la aparicion unica o sucesiva de multiples lentigos. Se cominican dos nuevos casos, uno de ellos en un nino de 12 anos de edad, de raza amarilla con trastornos electrocardiograficos, hipertelorismo e hipospadia y el otro se trata de una mujer de 24 anos que asociaba hipertelorismo, hipoacusia, escoliosis dorsal, sindactilia y disostosis mandibular de Franchesqueti. Se efectua una revision bibliografica enumerando las patologias asociadas y se realizan comentarios etiopatogenicos. Los autores consideran la utilidad practica del acrostico Leopard para la sistematizacion del estudio de estos enfermos
Subject(s)
Child , Humans , Male , NevusABSTRACT
La dermatosis ampollar cronica benigna del nino es una entidad caracterizada por la presencia de ampollas tensas, aisladas o agrupadas en forma de "roseta", que se localiza preferentemente en la zona pelviana pudiendo afectar otros sectores. La evolucion es benigna, con curacion en 2 o 3 anos. Fueron estudiados 6 casos en los cuales se destaca el predominio del sexo masculino (5/1) y algunas localizaciones poco frecuentes, como cuero cabelludo, orejas, manos, pies y mucosa lingual. La evolucion se efectuo por brotes, curando en el lapso de 3 a 41 meses, coincidiendo con la mayoria de los casos relatados.Desde el punto de vista histopatologico se observo una formacion ampollar dermoepidermica semejante a penfigoide ampollar en 3 casos y compatible com dermatitis herpetiformes en 2 de ellos. Los hallazgos de inmunofluorescencia directa no fueron constantes; en 2 casos se demostro deposito de IgA lineal en la zona de la union dermoepidermica, en otros 3 los resultados fueron negativos. En ninguno se pudo evidenciar anticuerpos circulantes con inmunofluorescencia
Subject(s)
Infant , Child, Preschool , Child , Humans , Male , Female , Skin Diseases, Vesiculobullous , Adrenal Cortex Hormones , Fluorescent Antibody Technique , Immunoglobulin A , SulfonesABSTRACT
La sebocistomatosis es una enfermedad hereditaria, trasmitida con caracter autosomico dominate. Se caracteriza por elementos quisticos aislados o agrupados,localizados en tronco, cara, orejas, cuello, torax, miembros y cuero cabelludo. Las lesiones mas superficiales pueden mostrar coloracion amarillenta: la expresion de esos elementos hace fluir liquido aceitoso. Otros elementos se inflaman y supuran. Histologicamente se observan quistes con pared delgada formada por celulas epiteliales asociadas con epitelio sebaceo y la estructura rudimentaria de la unidad pilosa, cuyo contenido es oleoso, con sebo y lanugo.Aunque en la mayor parte de los casos se trata de un proceso aislado, en otros puede asociarse con diversas enfermedades. En los dos casos que se comunican, la sebocistomatosis acompanaba acne e hipertricosis. Se plantean los diagnosticos diferenciales con otros quistes y otras hiperplasias sebaceas. Consideramos a esta entidad como una displasia sebacea genuina desde el punto de vista histogenetico
Subject(s)
Epidermal CystABSTRACT
La sebocistomatosis es una enfermedad hereditaria, trasmitida con caracter autosomico dominate. Se caracteriza por elementos quisticos aislados o agrupados,localizados en tronco, cara, orejas, cuello, torax, miembros y cuero cabelludo. Las lesiones mas superficiales pueden mostrar coloracion amarillenta: la expresion de esos elementos hace fluir liquido aceitoso. Otros elementos se inflaman y supuran. Histologicamente se observan quistes con pared delgada formada por celulas epiteliales asociadas con epitelio sebaceo y la estructura rudimentaria de la unidad pilosa, cuyo contenido es oleoso, con sebo y lanugo.Aunque en la mayor parte de los casos se trata de un proceso aislado, en otros puede asociarse con diversas enfermedades. En los dos casos que se comunican, la sebocistomatosis acompanaba acne e hipertricosis. Se plantean los diagnosticos diferenciales con otros quistes y otras hiperplasias sebaceas. Consideramos a esta entidad como una displasia sebacea genuina desde el punto de vista histogenetico
Subject(s)
Epidermal CystABSTRACT
La dermatosis ampollar cronica benigna del nino es una entidad caracterizada por la presencia de ampollas tensas, aisladas o agrupadas en forma de "roseta", que se localiza preferentemente en la zona pelviana pudiendo afectar otros sectores. La evolucion es benigna, con curacion en 2 o 3 anos. Fueron estudiados 6 casos en los cuales se destaca el predominio del sexo masculino (5/1) y algunas localizaciones poco frecuentes, como cuero cabelludo, orejas, manos, pies y mucosa lingual. La evolucion se efectuo por brotes, curando en el lapso de 3 a 41 meses, coincidiendo con la mayoria de los casos relatados.Desde el punto de vista histopatologico se observo una formacion ampollar dermoepidermica semejante a penfigoide ampollar en 3 casos y compatible com dermatitis herpetiformes en 2 de ellos. Los hallazgos de inmunofluorescencia directa no fueron constantes; en 2 casos se demostro deposito de IgA lineal en la zona de la union dermoepidermica, en otros 3 los resultados fueron negativos. En ninguno se pudo evidenciar anticuerpos circulantes con inmunofluorescencia
Subject(s)
Infant , Child, Preschool , Child , Humans , Male , Female , Skin Diseases, Vesiculobullous , Adrenal Cortex Hormones , Immunoglobulin A , Fluorescent Antibody Technique , SulfonesABSTRACT
A family with hereditary deficiency of the second component of complement was studied. Three siblings were homozygous for C2 deficiency and two of them had associated skin diseases. One sister presented with idiopathic atrophoderma and the other had clinical and pathological manifestations of discoid lupus erythematosus. This is the first description of an association between idiopathic atrophoderma and C2 deficient state.
Subject(s)
Complement C2/deficiency , Lupus Erythematosus, Discoid/complications , Skin Diseases/complications , Adolescent , Adult , Atrophy , Child , Child, Preschool , Complement C1 Inactivator Proteins , Complement C2/analysis , Complement System Proteins/analysis , Deficiency Diseases/genetics , Female , Humans , Male , Middle Aged , Pedigree , Skin Diseases/genetics , Skin Diseases/immunology , Skin Diseases/pathologyABSTRACT
Immunologic response to A and B erythrocytic antigen stimulation was studied in patients with pemphigus, in patients with systemic lupus erythematosus (SLE), and in normal subjects. Patients with pemphigus and normal subjects demonstrated a similar specific response (isohemagglutinins). A comparison between patients with pemphigus and SLE showed higher titers in the latter. Intercellular antibody titers increased after stimulation; corresponding titers were unaffected by isohemagglutinin absorption. Direct immunofluorescent studies showed IgG deposits in the intercellular spaces of the skin of the patients with pemphigus. However, C3 was found in the same sites in only three cases of pemphigus erythematosus. Immunofluorescent studies for IgG at the basal membrane were positive in only two cases of pemphigus erythematosus. Immunologic response of patients with pemphigus was similar to that of controls; however, it differed from that of patients with SLE.
