ABSTRACT
The effect of CO2 induced pH changes on the response of airway smooth muscle to theophylline was studied. Our data show that simulated respiratory acid-base disturbances (pH range 7.0 to 7.8) have no significant effect on the response of isolated guinea pig tracheal cylinders at basal tone to theophylline. On the other hand, tracheal cylinders precontracted with histamine showed a diminished sensitivity to theophylline at pH values above 7.40, and an enhanced sensitivity at pH values below 7.40.
Subject(s)
Carbon Dioxide/pharmacology , Theophylline/pharmacology , Trachea/drug effects , Animals , Guinea Pigs , Histamine/pharmacology , Hydrogen-Ion Concentration , In Vitro Techniques , Male , Muscle Contraction/drug effects , Muscle, Smooth/drug effectsSubject(s)
Bronchoscopy , Fiber Optic Technology , Bronchoscopes , Evaluation Studies as Topic , HumansABSTRACT
Evaluation of data from fiberoptic bronchoscopic procedures revealed that for peripheral bronchogenic carcinomas, the diagnostic yield was influenced by the size of the lesion and its distance from the hilum. Failure to diagnose visible carcinomas was related to inability to obtain deep specimens for biopsy. Biopsy, brushing, and washing were complementary procedures in diagnosing bronchogenic carcinomas.
Subject(s)
Bronchoscopy , Carcinoma, Bronchogenic/diagnosis , Lung Neoplasms/diagnosis , Biopsy , Bronchi/cytology , False Negative Reactions , False Positive Reactions , Fiber Optic Technology , Humans , Sputum/analysisABSTRACT
Pneumoperitoneum occurred in three adults receiving mechanical ventilatory support. Since the presence of a perforated viscus could not be confirmed by combinations of clinical, surgical, or autopsy findings in any of these patients, it appears that the free abdominal air in these patients was a complication of the ventilatory therapy. It is possible that such a complication may be more common than is currently recognized and thus should be added to the differential diagnosis of pneumoperitoneum.
