1.
Am J Nephrol
; 8(1): 35-9, 1988.
Article
in English
| MEDLINE
| ID: mdl-2835905
ABSTRACT
We assessed the effect of acyclovir therapy on renal function during a course of therapy for herpesvirus disease. Renal function was assessed by measuring the clearances of inulin, albumin, and beta 2-microglobulin at the beginning and end of acyclovir therapy. Thirty-two patients had valid paired inulin clearances and 21 had valid paired albumin and beta 2-microglobulin clearances. No significant mean decrement of renal function was observed; however, 2 patients had a reversible renal dysfunction associated with acyclovir therapy which disappeared soon after discontinuation of the drug and was unassociated with a prior or recurrent renal dysfunction in short-term follow-up.
Subject(s)
Acyclovir/adverse effects , Herpesviridae Infections/drug therapy , Immunosuppression Therapy/adverse effects , Kidney Diseases/chemically induced , Acyclovir/therapeutic use , Aged , Albuminuria/chemically induced , Child , Creatinine/blood , Female , Herpesviridae Infections/immunology , Humans , Infusions, Intravenous , Inulin , Kidney Transplantation , Male , beta 2-Microglobulin/urine
2.
Clin Chem
; 30(10): 1718-9, 1984 Oct.
Article
in English
| MEDLINE
| ID: mdl-6478610