ABSTRACT
Sarcoidosis is a chronic systemic granulomatous disease that occasionally affects the larynx. When the larynx is affected, the symptoms are frequently mild, but severe airway obstruction can occur. Although systemic corticosteroids are helpful, patients may become refractory to further drug administration. The current methods of treatment are here summarized, and the patient literature is reviewed. We also report a case of a young patient suffering from laryngeal sarcoidosis successfully treated by the antileprosy agent clofazimine and propose it as an alternative treatment of laryngeal sarcoidosis in patients refractory to corticosteroids.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Clofazimine/therapeutic use , Laryngeal Diseases/drug therapy , Leprostatic Agents/therapeutic use , Sarcoidosis/drug therapy , Adult , Airway Obstruction/etiology , Anti-Inflammatory Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Biopsy , Clofazimine/pharmacology , Deglutition Disorders/etiology , Dyspnea/etiology , Hoarseness/etiology , Humans , Laryngeal Diseases/complications , Laryngeal Diseases/pathology , Laryngoscopy , Leprostatic Agents/pharmacology , Male , Prednisone/therapeutic use , Sarcoidosis/complications , Sarcoidosis/pathology , Sleep Apnea Syndromes/etiology , Treatment OutcomeABSTRACT
628 pupils from both the northern and southern parts of West Germany (Baden-Württemberg, Bavaria, Lower Saxony, Schleswig-Holstein) were interviewed via an "infectious diseases" questionnaire: 44 questions dealt with vaccination (vaccination history, opinions of efficiency of different vaccines), 38 with problems concerning AIDS/HIV. The results indicated significant lack in the acceptance of most of the common immunisations. Improvement of AIDS/HIV-information, especially on HIV-transmission and psychosocial, economical and political consequences seems to be necessary. Possibilities of future health education for pupils are discussed.
Subject(s)
Acquired Immunodeficiency Syndrome/prevention & control , Attitude to Health , Communicable Disease Control/methods , Health Education/methods , School Health Services , Vaccination , Acquired Immunodeficiency Syndrome/psychology , Adolescent , Adult , Female , Humans , Male , Vaccination/psychologyABSTRACT
628 pupils from both the northern and southern parts of West Germany (Baden-Württemberg, Bavaria, Lower Saxony, Schleswig-Holstein) were interviewed via an "infectious diseases" questionnaire: 44 questions dealt with vaccination (vaccination history, opinions of efficiency of different vaccines), 38 with problems concerning AIDS/HIV. The results indicated significant lack in the acceptance of most of the common immunisations. Improvement of AIDS/HIV-information, especially on HIV-transmission and psychosocial, economical and political consequences seems to be necessary. Possibilities of future health education for pupils are discussed.
