ABSTRACT
The cerebral blood flow was studied by means of transcranial ultrasonographic recording in hemorrhagic strokes. In acute phase of stroke the diastolic and mean velocity was slowed down and the pulsation index PI and resistance index RI were increased. Following of the changes of these indices may be of prognostic importance.
Subject(s)
Brain Ischemia/etiology , Brain/blood supply , Cerebral Hemorrhage/complications , Cerebral Hemorrhage/diagnostic imaging , Aged , Brain/physiopathology , Cerebral Arteries/physiopathology , Cerebral Hemorrhage/physiopathology , Echoencephalography , Female , Humans , Male , Middle Aged , Prognosis , Ultrasonography, Doppler, TranscranialABSTRACT
A 45-years old unconscious woman was admitted to the hospital, where she died 3 days later. For the preceding month she had suffered from a headache. She had no past medical history. Cerebrospinal fluid pressure was increased, there were 350 mg/100 of protein, and 105 mg/100 of glucose. Neuropathological examination revealed that the main microscopic abnormality was massive accumulation of PAS-positive polyglucosan bodies (PB) in the cerebral hemispheres, brain stem and cerebellum. These bodies were found most frequently around the vessels, or diffusely in the nervous tissue beneath the pia, particularly in depth of the cortical sulci. They were observed in the processes of nerve cells, astrocytes, and microglia cells. The material stored in PB was strongly positive in PAS, and PAS-dimedone, weakly stained in H&E, the reaction to GFAP, RCA-1 and Bielschowsky methods appeared rather on PB periphery. The neuropathologic features are consistent with adult polyglucosan body disease and are distinctive from other conditions in which PB may accumulate.
Subject(s)
Brain Chemistry , Brain/ultrastructure , Inclusion Bodies/ultrastructure , Astrocytes/ultrastructure , Basophils/ultrastructure , Brain/metabolism , Brain Stem/chemistry , Brain Stem/metabolism , Brain Stem/ultrastructure , Cerebellum/chemistry , Cerebellum/metabolism , Cerebellum/ultrastructure , Cerebrospinal Fluid Proteins/analysis , Fatal Outcome , Female , Humans , Inclusion Bodies/metabolism , Middle AgedABSTRACT
Four women with SSPE during pregnancy were observed. The influence of pregnancy on the course of illness was in all patients unfavourable: the disease exacerbated, what could be explained by physiological immunosuppression connected with gestation. Delivery (in three cases by sectio caesarea) had no beneficial influence on the fatal course of SSPE. In two cases intrauterine necrosis of foetus took place in the 8th and 20th week from the beginning of SSPE. In other two cases healthy children were born. One of them does not exhibit any neurological abnormalities during the first 5 years of life.
Subject(s)
Fetal Death/etiology , Pregnancy Complications/diagnosis , Subacute Sclerosing Panencephalitis/diagnosis , Adult , Cesarean Section , Female , Humans , Pregnancy , Pregnancy Complications/surgery , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Subacute Sclerosing Panencephalitis/complications , Subacute Sclerosing Panencephalitis/surgeryABSTRACT
The authors report the results of encephalovolumetric (EVM) investigations carried out in 75 patients with ischaemic stroke. The search for correlations between the clinical state of the patients and EVM findings demonstrated such a correlation between changing brain volume and the course of stroke. Changes in the course of EVM curves may be of prognostic importance in acute ischaemic stroke.
Subject(s)
Brain Ischemia/diagnosis , Adult , Aged , Aged, 80 and over , Brain/pathology , Brain Ischemia/pathology , Female , Humans , Male , Methods , Middle Aged , PrognosisABSTRACT
The authors present an analysis of the clinical course of 6 cases of Creutzfeldt-Jakob disease (patients were aged from 27 to 59 years). The diagnosis was established during the life of the patients. In the neurological status dementia and syndromes of pyramidal and extrapyramidal lesions predominated. Neuropathological examinations in 5 cases demonstrated also considerable cerebellar damage, however, clinical signs of this damage were noted in two patients only. EEG findings were of greatest importance among the laboratory investigations.
Subject(s)
Creutzfeldt-Jakob Syndrome/diagnosis , Adult , Basal Ganglia Diseases/classification , Basal Ganglia Diseases/diagnosis , Cerebellar Diseases/diagnosis , Creutzfeldt-Jakob Syndrome/classification , Dementia/classification , Dementia/diagnosis , Diagnosis, Differential , Electroencephalography , Female , Humans , Male , Middle AgedABSTRACT
The method of vascular casts was used for investigation of the cerebral vessels in subjects with atherosclerosis. The studied material comprised 35 brains taken from patients aged 70-85 years who died after strokes and 5 brains of patients aged 21-30 years who died after traffic accidents as a control group. It was found that small vessels in the atherosclerotic brains were tortuous and had numerous narrowings, they appeared elongated, and their course differed from that in young subjects. The casting method provided oval-shaped impressions of endothelial cell nuclei which could not have been visualized so clearly with the previously used histological methods.
Subject(s)
Brain Ischemia/pathology , Brain/blood supply , Cerebral Infarction/pathology , Intracranial Arteriosclerosis/pathology , Models, Cardiovascular , Aged , Brain Ischemia/complications , Cerebral Infarction/etiology , Female , Humans , Intracranial Arteriosclerosis/complications , Latex , MaleABSTRACT
A case of segmental spinal necrosis is described involving the area of supply of the sulcocommissural artery. The location of the necrosis and recurrent course of the disease suggest a vasogenic mechanism of the disease in the patient with atherosclerosis and hypertension.
