Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 17 de 17
Filter
1.
Nutrients ; 16(6)2024 Mar 10.
Article in English | MEDLINE | ID: mdl-38542699

ABSTRACT

COVID-19, the most recent multi-dimensional global food crisis, challenged leadership and impacted individuals' personal networks. Two cross-sectional surveys were disseminated to women involved in their state's women's leadership committee to understand food waste behaviors. An egocentric network analysis was chosen as the methodology to better understand personal advice network characteristics and examine the impacts of Farm Bureau women's leadership committee members' advice networks on their food waste behavior. A multilevel model was conducted to identify factors related to respondents leading their network members toward positive food waste decisions. Independent variables included in the variables at the individual (e.g., each respondent's race, generation), dyadic (e.g., length respondent has known each member of her network), and network levels (e.g., proportion of the respondent's network that was female) were included in the model. Women were more likely to report connections with people they led to positive food waste behaviors and food security when: they had higher food waste sum scores, they were part of Generation X, the network member they led to more positive food waste behaviors was a friend, and if there were fewer women in their advice networks.


Subject(s)
Food Loss and Waste , Refuse Disposal , Humans , Female , Cross-Sectional Studies , Food , Food Security
2.
Foods ; 12(21)2023 Oct 29.
Article in English | MEDLINE | ID: mdl-37959075

ABSTRACT

We examined the impact of artisan cooperatives on East African women related to changes in consumer perception and food choice. We sought to understand how artisan cooperatives were impacting women's food security, diet, and nutrition. To comprehend the lived experiences of women, a qualitative, phenomenological study was conducted within three purposively selected cooperatives in Rwanda and Kenya. Data was collected using Rapid Rural Appraisal (RRA) methodologies with three activities. When given a choice, women did not always eat healthier despite having more money and information about healthy diets. Diets shifted to include more sugar and fruit but less vegetables. Culture and location impacted how they cooked, what food was available to them, and what foods they chose to consume. Women explained how a higher income provided greater agency when buying food. It is crucial to comprehend how culture affects a person's diet before implementation of nutrition programs. Further research is needed to determine if cooperatives geared toward women's empowerment and economic sustainability can enhance the nutritional benefits of increased income in culturally relevant ways. This study has implications regarding sustainable development goals with international development programs that utilize locally sourced foods and are culturally viable.

3.
Foods ; 12(11)2023 May 31.
Article in English | MEDLINE | ID: mdl-37297453

ABSTRACT

Precision farming provides one of the most important solutions for managing agricultural production to advance global food security. Extending professionals' competencies to promote precision farming practices can increase the adoption rate, ultimately impacting food security. Many studies have addressed barriers to the adoption of precision farming technologies from the farmers' perspective. However, few are available data on the perspectives of extension professionals. Agricultural extension professionals play an important role in innovative agricultural technology adoption. Thus, this study applied four constructs from the unified theory of acceptance and use of technology (UTAUT) model to investigate behavioral intentions to promote precision farming among extension professionals from two extension systems. In total, 102 (N = 102) agricultural extension professionals were surveyed. The results indicated that performance expectancy and social influence were individually significant predictors of extension professional behavioral intentions to promote precision farming technologies. There were no significant differences between the professionals of two extension systems. Gender, age, and years of service did not affect extension professionals' intention to promote precision agriculture technologies. The data suggested the need for training programs to develop advanced competencies to promote agricultural innovation. This study contributes to the future professional development programs for extension professionals on communicating innovations to address food security and sustainability issues.

4.
Article in English | MEDLINE | ID: mdl-36231410

ABSTRACT

Mental illness significantly impacts agricultural producers, whose occupation puts them at increased risk for compromised mental health and related disorders. Help-seeking intention, which can be mediated by variables such as social identity, social capital, and self-stigma, can lead to improved mental health outcomes. This cross-sectional study aimed to describe the intention of agricultural producers to seek mental health assistance and determine whether these three variables are associated with help-seeking intention. Researchers administered a cross-sectional survey of agricultural producers from two regions in 32 Texas counties. Researchers surveyed a sample of Texas agricultural producers (n = 429) to understand their social identity, social capital, and degree of self-stigma, and their intent to seek help for personal or emotional problems and for suicide ideation. Researchers identified a relationship between social identity and social capital, which indicated that social identity is moderately associated with greater levels of social capital. The multiple linear regression analyses confirmed that social capital and self-stigma are significant predictors of producers' help-seeking intention for both help-seeking types. These results signify the importance of efforts to increase social capital, increase mental health literacy and tailor training to address self-stigma and enhance positive help-seeking behavior among agricultural producers.


Subject(s)
Mental Disorders , Social Capital , Cross-Sectional Studies , Humans , Intention , Mental Disorders/epidemiology , Mental Disorders/psychology , Mental Health , Patient Acceptance of Health Care/psychology , Social Identification , Social Stigma
5.
Sensors (Basel) ; 22(18)2022 Sep 09.
Article in English | MEDLINE | ID: mdl-36146184

ABSTRACT

The study sought to: (1) evaluate agriculturalists' characteristics as adopters of IoT smart agriculture technologies, (2) evaluate traits fostering innovation adoption, (3) evaluate the cycle of IoT smart agriculture adoption, and, lastly, (4) discern attributes and barriers of information communication. Researchers utilized a survey design to develop an instrument composed of eight adoption constructs and one personal characteristic construct and distributed it to agriculturalists at an agricultural exposition in Rio Grande do Sul. Three-hundred-forty-four (n = 344) agriculturalists responded to the data collection instrument. Adopter characteristics of agriculturalists were educated, higher consciousness of social status, larger understanding of technology use, and more likely identified as opinion leaders in communities. Innovation traits advantageous to IoT adoption regarding smart agriculture innovations were: (a) simplistic, (b) easily communicated to a targeted audience, (c) socially accepted, and (d) larger degrees of functionality. Smart agriculture innovation's elevated levels of observability and compatibility coupled with the innovation's low complexity were the diffusion elements predicting agriculturalists' adoption. Agriculturalists' beliefs in barriers to adopting IoT innovations were excessive complexity and minimal compatibility. Practitioners or change agents should promote IoT smart agriculture technologies to opinion leaders, reduce the innovation's complexity, and amplify educational opportunities for technologies. The existing sum of IoT smart agriculture adoption literature with stakeholders and actors is descriptive and limited, which constitutes this inquiry as unique.


Subject(s)
Agriculture , Brazil
6.
Article in English | MEDLINE | ID: mdl-35457444

ABSTRACT

Sub-Saharan Africa will accommodate more population this century by having a multitude of births across the continent. Family planning methods provide women with techniques to manage their health and wellbeing. This study investigated how radio communications in family planning changed the perception of Ghanaian, Liberian, and Senegalese mothers toward having fewer children. Univariate and multivariate linear regression results after coarsened exact matching (CEM) with selected covariates for 15- to 49-year-old mothers from demographic and health survey (DHS) data implied the effectiveness of radio communications. This effort supports the need for further research on tailored communication methods for West African mothers over time.


Subject(s)
Contraception Behavior , Family Planning Services , Adolescent , Adult , Child , Developing Countries , Female , Ghana , Humans , Middle Aged , Sex Education , Young Adult
7.
Atten Defic Hyperact Disord ; 3(3): 237-44, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21442440

ABSTRACT

A three-year open-label study of atomoxetine in adults with ADHD followed two multicenter, double-blind trials. In the double-blind trials, female gender and higher levels of emotional symptoms were associated with better outcome. Following a 4-week placebo washout period, 384 (of 536) subjects continued into the open-label study. 61% of subjects entering this open-label study remained after 6 months at an average dose of 100 mg/day. Subjects who had previously responded to double-blind atomoxetine achieved maximum response after 8 weeks of open-label medication, but others continued to improve for 36 weeks. Women improved more (7.7 ± 6.4) than men (6.1 ± 6.4) on the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) (P = .007) and the Conners' Adult ADHD Rating Scale (P = .03). Subjects with emotional dysregulation improved more than others on the WRAADDS (P = .001). Responders ultimately improved approximately 60% in attentional, hyperactive/impulsive, and emotional symptoms. Thirty-nine percent of atomoxetine double-blind non-responders became responders during open-label treatment.


Subject(s)
Adrenergic Uptake Inhibitors/therapeutic use , Affective Symptoms/drug therapy , Attention Deficit Disorder with Hyperactivity/drug therapy , Propylamines/therapeutic use , Adult , Affective Symptoms/complications , Affective Symptoms/psychology , Atomoxetine Hydrochloride , Attention Deficit Disorder with Hyperactivity/psychology , Double-Blind Method , Female , Humans , Male , Psychiatric Status Rating Scales/statistics & numerical data , Sex Characteristics , Time Factors
8.
Ann Clin Psychiatry ; 22(3): 196-204, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20680193

ABSTRACT

BACKGROUND: This open-label trial followed a previously reported randomized, placebo-controlled trial of osmotic release oral system (OROS) methylphenidate (MPH) for the treatment of personality disorder (PD). Important findings from the double-blind phase are reexamined for long-term significance. METHODS: Of 41 patients who completed the double-blind, placebo-controlled trial, 34 continued into this open-label phase. The Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) measured outcome. Patients were categorized using previously defined attention-deficit/hyperactivity disorder (ADHD) groups: ADHD alone, ADHD with emotional dysregulation (ADHD + ED), and ADHD plus emotional dysregulation plus oppositional symptoms (ADHD + ED + ODD); and 3 post hoc personality categories: patients with no PD (PD-negative), patients with 1 PD (PD-positive), and patients meeting criteria for 2 or more PDs (PD-plus). RESULTS: Three WRAADDS-defined ADHD dimensions improved at similar levels (attention + disorganization, 61%; hyperactivity + impulsivity, 60%; and emotional dysregulation, 66%). All ADHD subgroups (ADHD alone, ADHD + ED, and ADHD + ED + ODD) improved. ADHD + ED + ODD patients had the highest level of social maladjustment at baseline and showed the most long-term improvement in this area. PD-plus patients were less likely to complete the study or show improvement. Sixty-five percent of treatment responders were on moderate doses (< or =54 mg/d) of OROS MPH. Vital signs and ECGs did not differ from baseline. CONCLUSIONS: Eighteen (44%) patients completed the trial. All 3 ADHD dimensions showed similar, well-maintained improvement. Patients with several PDs responded poorly to treatment in this small trial.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Central Nervous System Stimulants/therapeutic use , Methylphenidate/therapeutic use , Affective Symptoms/diagnosis , Affective Symptoms/drug therapy , Affective Symptoms/psychology , Attention Deficit Disorder with Hyperactivity/diagnosis , Attention Deficit Disorder with Hyperactivity/psychology , Attention Deficit and Disruptive Behavior Disorders/diagnosis , Attention Deficit and Disruptive Behavior Disorders/drug therapy , Attention Deficit and Disruptive Behavior Disorders/psychology , Central Nervous System Stimulants/adverse effects , Comorbidity , Cross-Over Studies , Delayed-Action Preparations , Dose-Response Relationship, Drug , Double-Blind Method , Follow-Up Studies , Humans , Long-Term Care , Methylphenidate/adverse effects , Personality Assessment , Personality Disorders/diagnosis , Personality Disorders/drug therapy , Personality Disorders/psychology , Social Adjustment , Utah
9.
Ann Clin Psychiatry ; 22(2): 84-93, 2010 May.
Article in English | MEDLINE | ID: mdl-20445835

ABSTRACT

BACKGROUND: Comorbidity of personality disorder (PD) and attention-deficit/hyperactivity disorder (ADHD) has been suggested in several reports. However, assessment of PD is problematic, and studies have over-relied on baseline evaluations. METHODS: Forty-seven patients entered a double-blind trial of osmotic release oral system (OROS) methylphenidate (MPH). Patients were assessed at baseline with the Wisconsin Personality Inventory IV (WISPI-IV) and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Following the study, all information-including tests, family reports, and extended clinical observations-produced a final PD diagnosis. Three post hoc categories were created: PD-negative (no PD), PD-positive (1 PD), and PD-plus (2 or more PDs). RESULTS: Twenty-one (45%) patients had a PD on the final assessment vs 62% using SCID-II and 33% using WISPI-IV; final PD diagnosis revealed 9% cluster A, 17% cluster B, and 28% cluster C. Twenty-one percent of patients experienced multiple disorders. Using a weighted kappa, the number of PDs on the final assessment correlated with the WISPI-IV (kappa=.53; P > .001) and the SCID-II (kappa =.70; P < .001). However the SCID-II overidentified and the WISPI-IV underidentified PD. CONCLUSION: Almost all PDs were represented in this sample, and past emphasis on cluster B appears unwarranted. Although the SCID-II and WISPI-IV had limited success in identifying specific PDs, they were more successful in identifying the number of PDs present in each patient. The small sample makes these findings preliminary.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Attention Deficit Disorder with Hyperactivity/epidemiology , Central Nervous System Stimulants/therapeutic use , Methylphenidate/therapeutic use , Personality Disorders/diagnosis , Personality Disorders/epidemiology , Adult , Attention Deficit Disorder with Hyperactivity/diagnosis , Comorbidity , Diagnostic and Statistical Manual of Mental Disorders , Dopamine Uptake Inhibitors/therapeutic use , Humans , Personality Assessment , Personality Disorders/classification , Psychological Tests , Randomized Controlled Trials as Topic
10.
Ann Clin Psychiatry ; 22(2): 94-102, 2010 May.
Article in English | MEDLINE | ID: mdl-20445836

ABSTRACT

BACKGROUND: This study explored the relationship between personality disorder (PD) and treatment response in a randomized, double-blind, clinical trial of osmotic release oral system (OROS) methylphenidate (MPH). METHODS: Forty-seven patients entered a crossover trial using the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) to assess outcome. A final personality diagnosis was made using staff consensus and information from the Wisconsin Personality Inventory IV (WISPI-IV) and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). Three post hoc categories were created: PD-negative (no PD; n = 26), PD-positive (patients with 1 PD; n = 11), and PD-plus (patients with 2 or more PDs; n = 10). Improvement in attention-deficit/hyperactivity disorder (ADHD) symptoms was assessed using a mixed-model analysis with treatment and personality categories as fixed variables. Average z scores on the WISPI-IV and items endorsed on SCID-II provided dimensional measures of PD severity. RESULTS: Different treatment effects were observed for the PD subgroups (P < .001). PD-negative patients improved 40% on OROS MPH vs 7% on placebo, and PD-positive patients improved 66% on OROS MPH vs 9% on placebo. In contrast, PD-plus patients improved 26% on OROS MPH vs 23% on placebo. CONCLUSION: Most patients experienced significantly reduced ADHD symptoms on OROS MPH; however, patients with 2 or more PDs did not. The 2 alternate measures of PD supported this observation in this small exploratory study.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Attention Deficit Disorder with Hyperactivity/epidemiology , Central Nervous System Stimulants/therapeutic use , Dopamine Uptake Inhibitors/therapeutic use , Methylphenidate/therapeutic use , Personality Disorders/diagnosis , Personality Disorders/epidemiology , Adult , Comorbidity , Female , Humans , Male , Personality Assessment , Psychological Tests , Randomized Controlled Trials as Topic , Severity of Illness Index
11.
Ann Clin Psychiatry ; 22(2): 103-12, 2010 May.
Article in English | MEDLINE | ID: mdl-20445837

ABSTRACT

BACKGROUND: This study explored the relationship between the dimensions of adult attention-deficit/hyperactivity disorder (ADHD), personality disorder (PD), and adverse social adjustment. METHODS: In a controlled trial of osmotic release oral system methylphenidate, PD was assessed using the Wisconsin Personality Disorders Inventory IV (WISPI-IV), the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), and a final consensus diagnosis. Participants were categorized 2 ways: (1) ADHD alone, ADHD with emotional dysregulation (ADHD + ED), and ADHD plus emotional dysregulation plus oppositional symptoms (ADHD + ED + ODD); and (2) those with no PD (PD-negative), 1 (PD-positive), and 2 or more (PD-plus) PDs. RESULTS: None of the ADHD-alone patients had a PD compared with 33% of ADHD + ED patients and 68% of ADHD + ED + ODD patients. The level of ADHD-related emotional and oppositional symptoms correlated significantly with the severity of PD dimensions as assessed by WISPI-IV z scores and the number of items endorsed on the SCID-II screening questionnaire. Complex presentations (define by both ADHD and personality categories) were associated with high childhood ADHD ratings and problems in work, extended family, and economic functioning. CONCLUSION: The ADHD symptoms of emotional dysregulation and oppositional symptoms were associated with increased Axis II disorders. Adverse outcomes were concentrated in patients with ADHD combined with emotional and oppositional symptoms, and in those with comorbid PDs.


Subject(s)
Attention Deficit Disorder with Hyperactivity/psychology , Personality Disorders/diagnosis , Personality Disorders/psychology , Social Adjustment , Adult , Affective Symptoms/physiopathology , Attention Deficit Disorder with Hyperactivity/drug therapy , Attention Deficit Disorder with Hyperactivity/epidemiology , Central Nervous System Stimulants/therapeutic use , Comorbidity , Conflict, Psychological , Diagnostic and Statistical Manual of Mental Disorders , Dopamine Uptake Inhibitors/therapeutic use , Female , Humans , Male , Methylphenidate/therapeutic use , Personality Assessment , Personality Disorders/epidemiology , Randomized Controlled Trials as Topic
12.
Depress Anxiety ; 26(3): 273-8, 2009.
Article in English | MEDLINE | ID: mdl-19016463

ABSTRACT

BACKGROUND: Bright visible-spectrum light therapy has proven effective in the treatment of seasonal affective disorder (SAD) and recent basic research suggests that blue wavelengths approximately 470 nm account for that effectiveness. To more stringently test the importance of these wavelengths, bright red-light was used for the placebo (control) condition. METHODS: Thirty subjects meeting DSM-IV criteria for SAD were randomized to narrow-band light-emitting diode panels emitting blue- or red-light in this 3-week, parallel, double-blind trial. Twenty-five subjects participated in an open-label blue-light follow-up. Subjects were divided in a blinded, post hoc manner into two groups: SAD only and those experiencing depression with seasonal intensification. The outcome was assessed using Hamilton Depression Rating Scale-17 item version (HAMD-17) and the Structured Interview Guide for the Hamilton Depression Rating Scale-SAD version. Responders were defined by Clinical Global Impression-Improvement scale. RESULTS: HAMD-17 scores improved more under the blue-light condition (51%) than under the red-light condition (32%) (P=.05). Further, in the blue arm 60% of subjects responded compared with 13% in the red arm (P=.01). During the open-label phase, subjects from both double-blind arms improved over baseline. SAD alone patients responded numerically better to treatment than those experiencing depression with seasonal intensification during both treatment periods. CONCLUSIONS: Narrow bandwidth blue-light therapy proved superior to red-light therapy. Blue-light therapy produced results similar to both previous 10,000 lux visible-spectrum light studies and many medication studies. The use of bright red panels supported claims that wavelengths of approximately 470 nm account for the documented effectiveness of light therapy.


Subject(s)
Phototherapy/methods , Seasonal Affective Disorder/therapy , Adult , Diagnostic and Statistical Manual of Mental Disorders , Double-Blind Method , Female , Humans , Male , Seasonal Affective Disorder/diagnosis , Seasonal Affective Disorder/psychology , Severity of Illness Index , Surveys and Questionnaires
13.
J Clin Psychiatry ; 68(1): 93-101, 2007 Jan.
Article in English | MEDLINE | ID: mdl-17284136

ABSTRACT

BACKGROUND: The realization that attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood has led to increased frequency of diagnosis and treatment in adults. Osmotic release oral system (OROS) methylpheni-date is a long-acting stimulant demonstrated to be effective in the treatment of children and adolescents with ADHD. METHOD: Forty-seven adults entered and 41 completed this double-blind, placebo-controlled, crossover trial of OROS methylphenidate. Each double-blind arm lasted 4 weeks; data were collected from August 2004 through December 2005. Subjects met both DSM-IV-TR and Utah Criteria for ADHD in adults. Outcome measures included the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS), the adult ADHD-Rating Scale (ADHD-RS), and the Clinical Global Impressions-Improvement scale (CGI-I). At baseline, subjects were categorized as having significant emotional symptoms with the WRAADDS and/or significant oppositional-defiant symptoms using a self-report scale assessing the DSM-IV criteria for oppositional defiant disorder. RESULTS: 17% of the sample (N = 8) had ADHD alone, 38% (N = 18) had ADHD plus significant emotional symptoms, and 40% (N = 19) had ADHD with both significant emotional and oppositional symptoms. At a mean +/- SD dose of 64.0 +/- 23.3 (0.75 mg/kg), OROS methylphenidate proved superior to placebo for all clinical measures: total WRAADDS score decrease of 42% versus 13%, respectively, p < .001 and total ADHD-RS score decrease of 41% versus 14%, respectively, p = .003, plus the subscales addressing inattention, hyperactivity/ impulsivity, and emotional dysregulation. CONCLUSIONS: OROS methylphenidate proved effective in treating adult ADHD. ADHD alone was relatively uncommon. Over 80% of our patients had ADHD with a combination of emotional and/or oppositional symptoms.


Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Attention Deficit Disorder with Hyperactivity/psychology , Central Nervous System Stimulants/administration & dosage , Central Nervous System Stimulants/therapeutic use , Methylphenidate/administration & dosage , Methylphenidate/therapeutic use , Administration, Oral , Adult , Affective Symptoms/psychology , Attention Deficit and Disruptive Behavior Disorders/psychology , Cross-Over Studies , Delayed-Action Preparations , Double-Blind Method , Female , Humans , Male , Middle Aged , Osmosis , Treatment Outcome
14.
Psychother Psychosom ; 76(1): 40-6, 2007.
Article in English | MEDLINE | ID: mdl-17170562

ABSTRACT

BACKGROUND: Some reports suggest that a subset of depressed patients may experience suicidality - that is increase or emergence of suicidal ideation (SI) or behavior--after initiation of an antidepressant. The time course and clinical correlates of this phenomenon have not been characterized in detail. METHOD: We conducted a secondary analysis of a multicenter, prospective, open, 12-week trial of fluoxetine 20 mg in outpatients with nonpsychotic major depressive episodes. Adverse effects and other clinical features associated with the emergence of suicidality, defined using item 3 of the Hamilton Depression Rating Scale, were examined using Cox regression models. RESULTS: Among 414 subjects without SI at baseline, 59 (14.3%) reported SI on at least 1 postbaseline visit. In a Cox regression, emergence of activation and worsening of depression severity were independently associated with emergence of SI, along with female gender, younger age and having thoughts that life was not worth living prior to treatment. Treatment response and remission were significantly less likely among subjects who developed SI. CONCLUSIONS: New SI was relatively common in this trial of fluoxetine and associated with the emergence of activation and overall symptomatic worsening. Whether prophylaxis against or aggressive treatment of adverse events can decrease emergence of SI merits further study.


Subject(s)
Depressive Disorder, Major/drug therapy , Drug Therapy/statistics & numerical data , Fluoxetine/adverse effects , Selective Serotonin Reuptake Inhibitors/adverse effects , Suicide, Attempted/psychology , Adolescent , Adult , Aged , Ambulatory Care , Depressive Disorder, Major/diagnosis , Drug Administration Schedule , Female , Humans , Incidence , Male , Middle Aged , Severity of Illness Index , Surveys and Questionnaires
15.
Biol Psychiatry ; 58(2): 125-31, 2005 Jul 15.
Article in English | MEDLINE | ID: mdl-16038683

ABSTRACT

BACKGROUND: Before 1980, attention-deficit/hyperactivity disorder (ADHD) was called minimal brain dysfunction and included emotional symptoms now listed as "associated features" in DSM-IV. Data from two multicenter, placebo-controlled studies with 536 patients were reexamined to assess: 1) the pervasiveness of these symptoms in samples of adults with ADHD; 2) the response of these symptoms to atomoxetine; and 3) their association with depressive/anxiety symptoms. METHODS: The Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) was used to assess temper, affective lability, and emotional overreactivity, thus identifying patients exhibiting "emotional dysregulation." Other DSM-IV Axis I diagnoses were exclusionary. Outcome measures were the Conners' Adult ADHD Rating Scale (CAARS) and the WRAADDS. RESULTS: Thirty-two percent of the sample met post hoc criteria for emotional dysregulation and had higher baseline scores on ADHD measures, a lower response to placebo, and greater response to atomoxetine (p = .048). Symptoms of emotional dysregulation had a treatment effect (p < .001) at least as large as the CAARS (p = .002) and the total WRAADDS (p = .001). Emotional dysregulation was present in the absence of anxiety or depressive diagnosis. CONCLUSIONS: Symptoms of emotional dysregulation were present in many patients with ADHD and showed a treatment response similar to other ADHD symptoms.


Subject(s)
Adrenergic Uptake Inhibitors/therapeutic use , Affective Symptoms/drug therapy , Attention Deficit Disorder with Hyperactivity/drug therapy , Mood Disorders/drug therapy , Propylamines/therapeutic use , Adult , Affective Symptoms/complications , Affective Symptoms/metabolism , Analysis of Variance , Anxiety Disorders/complications , Anxiety Disorders/drug therapy , Atomoxetine Hydrochloride , Attention Deficit Disorder with Hyperactivity/complications , Attention Deficit Disorder with Hyperactivity/metabolism , Depressive Disorder/complications , Depressive Disorder/drug therapy , Double-Blind Method , Female , Humans , Male , Middle Aged , Mood Disorders/complications , Mood Disorders/metabolism , Norepinephrine/metabolism
16.
Neuropsychiatr Dis Treat ; 1(3): 245-51, 2005 Sep.
Article in English | MEDLINE | ID: mdl-18568102

ABSTRACT

Increased attention has been given to the alternatives to stimulants in the treatment of attention deficit hyperactivity disorder (ADHD) in both adults and children. This short-term, double-blind trial was designed to evaluate the extended-release form of bupropion in adult subjects meeting DSM-IV and the Utah Diagnostic Criteria for ADHD. Outcome measures were the Clinical Global Impressions-Improvement (CGI-I) and the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS), which assesses adult ADHD symptoms. Outcome (defined by the CGI-I, average WRAADDS scores, or a 50% improvement on the WRAADDS) favored bupropion SR over placebo, but achieved statistical significance on only one, post hoc measure. Other measures showed trends for improvement with bupropion. Given the small size of this study, these findings deserve further exploration.

17.
J Affect Disord ; 79(1-3): 297-303, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15023511

ABSTRACT

BACKGROUND: Recent reports suggesting lamotrigine as an effective treatment in bipolar disorder, and perhaps borderline personality disorder, a common comorbid personality disorder in bipolar patients, led us to retrospectively examine patients from two bipolar studies to investigate this pattern of comorbidity, and to determine whether lamotrigine effected the dimensions of borderline personality. METHODS: Fifteen months following entry into either study, we retrospectively assessed DSM-IV dimensions of borderline personality disorder pre- and post-treatment with lamotrigine in 35 bipolar patients. RESULTS: Forty percent met criteria for borderline personality disorder; this subgroup had a more frequent history of substance abuse and childhood symptoms of attention deficit hyperactivity disorder (ADHD). Dimensions of borderline personality improved significantly with treatment in both patient groups, and corresponded with response of bipolar symptoms. Six (43%) comorbid bipolar patients endorsed three or fewer criteria of borderline personality during treatment with lamotrigine. There was a trend for comorbid bipolar patients to require a second psychoactive medication in addition to lamotrigine during extended treatment. LIMITATIONS: Criteria for borderline personality and improvement were assessed retrospectively in an open manner. CONCLUSIONS: Dimensions of borderline personality disorder may respond to lamotrigine in comorbid bipolar patients; controlled studies appear warranted. Bipolar studies should assess and specify the number of patients with personality disorders in the trial.


Subject(s)
Antidepressive Agents/therapeutic use , Bipolar Disorder/drug therapy , Bipolar Disorder/psychology , Borderline Personality Disorder/drug therapy , Borderline Personality Disorder/etiology , Triazines/therapeutic use , Adult , Antidepressive Agents/pharmacology , Bipolar Disorder/complications , Comorbidity , Female , Humans , Lamotrigine , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Triazines/pharmacology
SELECTION OF CITATIONS
SEARCH DETAIL
...