[Experience with glyciphonic ointment therapy for primary multiple basal cell carcinoma of the skin]. / Opyt lecheniia pervichno-mnozhestvennogo bazal'nokletochnogo raka kozhi glitsifonovoi maz'iu.

The effectiveness of glycifone ointment treatment for primary multiple basal cell carcinoma of the skin was evaluated in 28 patients. 27 cases were cured following one or two courses the duration of which was determined by the number of foci, pattern of tumor and its total surface area.

[Experience with glyciphonic ointment for malignant and precancerous lesions of the skin]. / Opyt primeneniia glitsifonovoi mazi pri rake i predrakovykh zabolevaniiakh kozhi.

Skin was smeared with glyciphonic ointment containing 30% of methylphosphonic diglycidyl ether (Tatkhimfarmpreparaty Company) in 495 patients with histologically confirmed basalioma and 36 patients with senile keratosis. During daily application necrotic tissue was removed. Considerable decomposition of tumor occurred on day 6 or later. It took the wound 9-12, seldom, 15 days to heal, with scars forming on days 15-20. Stable cure was registered (5-7 yrs) in 492 patients with skin basalioma and all cases of senile keratosis. No changes in peripheral blood count or any skin-resorption side-effects were recorded. Several patients suffered hyperemia, edema, itching or local pain.

[Glyciphonic ointment in the treatment of radiation-induced basal cell carcinoma of the skin]. / Lechenie glitsifonovoi maz'iu bazal'nokletochnogo raka kozhi, indutsirovannogo radiatsionnym izlucheniem.

Skin basalcell carcinoma of the head and neck occurring within 1.5-23 yrs on the site of radiation fibrosis were smeared daily with glyciphonic ointment without dressing the wound. Tumor disintegrated after 2-6 applications followed by edema tumor tissue development on days 22-24. After a 2-3 week interval, perifocal edema subsided, and tumor deed shrank leaving a small scab. Basalioma cells were detected underneath. Complete cure was recorded after another 2-3 week therapy in all cases. Only one patient relapsed three years later.

[The toxicity and biological effects of organophosphorus epoxides]. / Toksichnost' i nekotorye biologicheskie éffekty fosfororganicheskikh époksidov.

In the series of glycidylic ethers of alkylophosphoric and methylphosphoric acids three types of compounds have been identified: those possessing anticholinesterase, narcotic, and antineoplastic activity. Monoglycidylic ethers of diethyl- and diisopropylphosphoric acids and diglycidylic ether of ethylphosphoric acid caused intoxication of animals with the cholinergic excitation syndrome, and in vitro in a concentration of 1 mmol/liter strongly inhibited cholinesterase, stimulated the motor activity of an intestinal segment, but did not demonstrate cytotoxic activity in relation to NK/Ly strain tumor cells. Monoglycidylic ethers of di-n-propyl-, di-iso-butyl, and di-n-butyl-phosphoric acids as well as diglycidylic ethers of n-butyl- and iso-amylphosphoric acids caused a "hypnotic state" in the animals, suppressed the motor activity of an isolated intestinal segment, considerably increased the number of diffusely stained by Aizenman's [correction of Aisenmanns'] method cells of ascitic NK/Ly tumor in vitro, but poorly inhibited the growth of this tumor in chemotherapeutic experiments. Diglycidylic ethers of methyl-, n-propyl-, iso-butylphosphoric, and methylphosphonic acids caused poisoning of the type of intoxication by alkylating agents, weakly influenced cholinesterase activity, did not change the character of contractions of the intestinal segment. In vitro they caused a strong cytotoxic effect, but delayed the growth of the NK/Ly tumor treated animals by 84-100%. The possibility of the phosphororganic epoxides under study taking part in the reactions of alkylation and phosphorylation is suggested.

[Antimutagens as modifiers of the cellular cyclase system]. / Antimutageny kak modifikatory tsiklaznoi ssistemy kletki.

Ability of adenosine, caffeine, theophylline, cAMP, dimephosphone, PABA and tocopherol acetate to modify the rate of mutagenesis induced as well as to affect the content of endogenous cAMP were studied in experiments with seeds of Crepis capillaries. Those concentrations of these drugs which decreased the rate of mutations, were shown to increase the content of endogenous cAMP in the seeds. Higher concentrations of the drugs did not exhibit any antimutagenic activity as well as did not contribute to an increase in the cAMP content, but sometimes decreased distinctly cyclonucleotide content in the seeds.

[The effect of dimephosphon, sermion and piracetam on the reactivity of the cerebral vessels, on local cerebral blood flow and on oxygen tension in brain tissue]. / Vliianie dimefosfona, sermiona i piratsetama na reaktivnost' mozgovykh sosudov, lokal'nyi mozgovoi krovotok i napriazhenie kisloroda v tkani golovnogo mozga.

The paper gives the results of experimental and clinical studies of the nootropic agents dimephosphone, sermion, and piracetam on local cerebral circulation, cerebrovascular responsiveness and O2 tension. The vasoactivity of the parameters studied has been shown to be displayed by their ability to normalize cerebrovascular responsiveness and it is associated with decreased brain tissue oxygen consumption when dimephosphone is applied and with its increased one when sermion and piracetam are used.

[An evaluation of the skin-resorptive action of dimephosphon when used locally long term]. / Otsenka kozhno-rezorbtivnogo deistviia dimefosfona pri dlitel'nom mestnom primenenii.

Experiments in rabbits and rats established that 15% dimephosphonum solution after its topical (skin) application over a long period of time (2 and 6 months) exerted no toxic skin-resorption effects, reduced blood lipid and lipid peroxidation product levels. The substance of dimephosphonum after 6-month daily skin applications caused reversible changes in renal and adrenal functions.

[Quantitative and qualitative criteria for assessing the efficacy of antimutagens in an experiment]. / Kolichestvennye i kachestvennye kriterii otsenki éffektivnosti antimutagenov v éksperimente.

The antimutagenic effect of para-aminobenzoic acid, tocopherol, adenosine and caffeine has been studied in experiments with microorganisms, Crepis capillaris seed cells, human lymphocytes, murine bone marrow cells in vivo. The activity, of antimutagens, their nature and action range, effective concentrations have been assessed. The type and severity of removable damages have been identified. Quantitative criteria for evaluating the effects of antimutagens have been defined.

[An experimental validation of the combined use of dimephosphon with nonsteroidal anti-inflammatory preparations]. / Eksperimental'noe obosnovanie kombinirovannogo primeneniia dimefosfona s nesteroidnymi protivovospalitel'nymi preparatami.

The effects of dimephosphon combined with nonsteroidal anti-inflammatory drugs were studied in rats and mice with experimental inflammation. The influence of dimephosphon on ulcerogenic activity of these drugs was also investigated. The dependence of the combinations efficiency on the scheme of dimephosphon administration was established. Synergism in anti-inflammatory activity between dimephosphon and ortophen (sodium diclofenac), indomethacin, and acetylsalicylic acid was shown. The possibility of decreasing the ulcerogenic effects of the drugs by dimephosphon was established. The effects of dimephosphon combinations are discussed as the basis for their use in clinical practice.

[The mechanism of action of dimephosphon]. / Mekhanizm deistviia dimefosfona.

It has been established in experiments on rats that the 7-day administration of dimephosphon per os increases blood levels of total mercapto groups and glutathione, changing the correlation of its forms in favour of the oxidized ones. This course of dimephosphon administration reduces blood concentration of lipid peroxidation products. The significance of these mechanisms in realization of the pharmacological effects of dimephosphon is under discussion.

[The chemoluminescence of the primary focus of a suppurative infection and of isolated neutrophils exposed to dimephosphon]. / Khemiliuminestsentsiia pervichnogo ochaga gnoinoi infektsii i izolirovannykh neitrofilov pri vozdeistvii dimefosfona.

The influence of dimephosphone at concentrations of 0.001 M-0.75 M on the chemiluminescence of tissues at the focus of purulent infection in the ear of a guinea pig, on the survival rate of the experimental animals injected with the lethal dose of Staphylococcus aureus, as well as on the spontaneous and stimulated chemiluminescence of blood neutrophils in patients with wound infection, was studied. The study showed that different concentrations of dimephosphone oppositely influenced the intensity of the chemiluminescence of neutrophil suspensions and tissues at the focus of infection: low concentrations were found to produce stimulating action and high concentrations, suppressive action. At the highest concentration used in this study (0.75 M) dimephosphone prevented the death of the animals receiving lethal doses of S. aureus.

[The effect of dimephosphon on exudative and proliferative processes]. / Vliianie dimefosfona na protsessy ékssudatsii i proliferatsii.

The effects of dimephosphon on the models of inflammation which permitted the separation of the exudative and proliferative phases were studied on rats. The drug effect on the levels of histamine, serotonin and their precursors in blood of healthy rats was also investigated. Dimephosphon was found to exert no inhibitory influence on the proliferative reaction in contrast to the well-known non-steroidal anti-inflammatory drugs. The antihistamine activity of dimephosphon occurring on account of the intensification of histaminopexy was established. It is suggested that the antihistamine activity of dimephosphon should be used for therapeutic purposes.

[Effect of dimephosphon on the adenine nucleotide system]. / Vliianie dimefosfona na sistemu adenilovykh nukleotidov.

The effect of a single injection of dimephosphon (1 mM/kg) on adenine nucleotide system in the liver of healthy and chlorophos-poisoned (a mean lethal dose) rats was studied. It was shown that in healthy rats dimephosphon decreased the levels of all components of adenylate system without changing the energy charge of adenylates. The treatment of the poisoned animals with dimephosphon normalized the parameters of energy metabolism disturbed by chlorophos intoxication.

[Effect of dimephosphon on the inflammatory reaction]. / Vliianie dimefosfona na vospalitel'nuiu reaktsiiu.

The effect of dimephosphon on the development of the experimental inflammatory edema (agar-, dextran- and carrageenan-induced edema) of rat and mouse paws was compared with those of voltaren and dimedrol. The anti-inflammatory activity of dimephosphon occurring on account of the antiexudative component was established. The antihistamine and antiserotonin activity of dimephosphon was shown on models of paw edema caused by subplantar administration of mediators and modulators of inflammation. The drug exerts no influence on similar effects of bradykinin and prostaglandin E2, intensifies edema-inducing action of prostaglandin F2 alpha. The involvement of the anti-inflammatory component in the therapeutic effect of dimephosphon is suggested.