Urogranoic acid as a radiopaque additive to the cyanoacrylic adhesive in transcatheter obliteration of renal arteries.

The purpose of the investigation was to study the application of radiopaque materials to the tissue adhesive base of the ester of n-butylic-alpha-cyanoacrylic acid for use in direct transcatheter renal artery obliteration. Lipiodol Ultra-fluid (Ethiodol) and urogranoic acid in quantities of 30--55% by weight of the adhesive were used as the radiopaque agents. The study was performed on seven dogs; obliterative material was administered through a telescopic, coaxial catheter system. Two dogs treated with the Lipiodol adhesive material died, which confirmed the inefficacy of Lipiodol for this purpose. In the other five dogs, treated by adding urogranoic acid to the adhesive, complete and permanent occlusion occurred and the adhesive remained radiopaque for 60--90 days. One of these dogs died of canine distemper infection. The complication of unpredictable embolization of the femoral artery appeared in a second dog. The same material has been used in two cases of nonoperative hypernephroma in humans. Permanent occlusion of the renal artery and elimination of hematuria were achieved. The obliterative material was sufficiently opaque for radiographic visualization.

[Surgical treatment of experimental liver injuries in dogs with special evaluation of Polish-made cyanoacrylic glue. I. Clinical observations, morphological and biochemical studies of blood and autopsy studies]. / Chirurgiczne leczenie doswiadczalnych ran watroby u psów, ze szczególnym uwzglednieniem wartosci kleju cyjanoakrylowego produkcji krajowej. I. Obserwacje kliniczne, badania morfologiczne i biochemiczne krwi oraz badania sekcyjne.

Liver wounds were experimentally induced in dogs. The wounds were dressed with catgut suture, suture and fibrinous sponge and ester n-butyl alfa-cyanoacrylic acid in aerosol form obtained laboratorially at the Institute of Organic Chemistry--Polish Academy of Sciences in Warsaw. The basis for evaluation were clinical observations of the operated animals, morphological and biochemical examination of blood and dissection. It was found that the best results were achieved with the surgical glue. Application of this monomer in aerosol form to join and dress liver wounds helps to close them tightly in a short time and obtain full hemostasis and stop bile leaking.

[Surgical treatment of experimental liver injuries in dogs with special evaluation of Polish-made cyanoacrylic glue. II. Histological and histochemical studies]. / Chirurgiczne leczenie doswiadczalnych ran watroby u psów, ze szczególnym uwzglednieniem wartosci kleju cyjanoakorylowego produkcji krajowej. II. Badania histologiczne i histochemiczne.

Liver wounds were experimentally induced in dogs. The wounds were dressed with catgut suture, suture and fibrinous sponge and ester n-butyl alfa-cyanoacrylic acid obtained laboratorially at the Institute of Organic Chemistry -- Polish Academy of Sciences in Warsaw. The basis for evaluation were histological, histochemical and histoenzymatic examinations of the operated liver. It was found that during the process of healing of wound dressed with the glue there were weaker inflammatory reactions and destruction of tissues was smaller than that in the case of surgical suture.