1.
Angew Chem Int Ed Engl
; 48(26): 4853-7, 2009.
Article
in English
| MEDLINE
| ID: mdl-19322865
ABSTRACT
The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single-site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores-such change requires additional noncovalent interactions or second-site attachments.