[Clinical-immunological and ecological research in diabetic retinopathy]. / Kliniko-immunologicheskie i ékologicheskie issledovaniia pri diabeticheskoi retinopatii.

Two hundred and ninety-six patients with diabetic retinopathy (DR) were examined: conservative therapy and laser coagulation of the retina were applied in 120 and 176 of them, respectively. The ecological situation in the residence region and its impact on the morbidity and immune status of DR patients were analyzed. The comfort degree of the environment and the level of anthropogenic contamination affect the morbidity and immunogram results. Immune-correctors, i.e. T-activin, sodium nucleinate and laser blood irradiation (LBI), were used within treatment schemes in DR. Laser coagulation of the retina is advisable to assign in combination with sodium nucleinate and LBI in the aftercare of patients concurrently with complex therapy; T-activin is used, within conservative therapy, to correct the unfavorable ecological impact exerted on patient's body.

[Clinical-immunological and epidemiological studies in high complicated myopia]. / Kliniko-immunologicheskie i épidemiologicheskie issledovaniia pri vysokoi oslozhnennoi miopii.

A total of 100 patients with high complicated myopia were examined. Immunodeficiency syndrome and signs of autosensitization were revealed in this patient population. Analysis of morbidity and its relationship with some environmental factors and characteristics of the activity of public health system showed that the morbidity was related to increased radioactivity and to unsatisfactory status of water in a region, and that increase of the number of medical workers may help reduce the morbidity.

[A theory on the role of immunologic factors in the pathogenesis of primary glaucoma]. / Kontseptsiia uchastiia immunnykh faktorov v patogeneze pervichnoi glaukomy.

Basing on the literature data and their own clinical, immunomorphologic, and immunochemical findings in glaucoma patients and normal subjects, the authors suggest a concept on the immune factor contribution to the pathogenesis of primary open-angle glaucoma. According to the scheme they suggest, of primary importance in the development of autoimmune reactions in glaucoma are the following factors: changed antigenic specificity of the drainage zone tissues, resultant from involution processes; impaired immune homeostasis, effects of various internal and environmental factors. The pathogenetic role of autoimmune reactions and immunity system regulatory mechanism disorders is explained.

[Experience with the surgical treatment of the sequelae of uveal tract diseases]. / Opyt khirurgicheskogo lecheniia posledstvii zabolevanii sosudistogo trakta.

The paper describes results of investigation of immunologic reactivity and analysis of outcomes after surgical treatment of patients with chronic anterior uveitis (14 persons), the Fuchs' syndrome (16 persons), pseudoexfoliative syndrome (25 persons) as compared with a control group (50 persons). Immunocorrection of patients with the Fuchs' syndrome was attempted, and analysis of the immunologic status before and after treatment by means of sodium nucleinate immunomodulator and traditional therapy was made. Cataract extraction was performed separately or in combination with sinusotrabeculectomy in case of uveal glaucoma. Immunodeficient syndrome was revealed in patients with chronic uveitis and the Fuchs' syndrome as well as the most severe course of the operation and the postoperative period in patients with chronic uveitis. Considering the important role of immunologic status of the body in the postoperative period, it is recommended to use immunomodulators in a complex treatment of patients with complicated cataract and glaucoma and diseases of the uveal tract.