ABSTRACT
The results of experimental and clinical use of stimulants of local reparative processes (autologous purified lipoaspirate and platelet-rich plasma) in the treatment of chronic gastric ulcer were analyzed. In the experimental part of the study the benefits of using platelet-rich plasma as donator growth factors were proved. The ability to stimulate the activity of fibroblasts and vessels formation in the young connective tissue with improving of oxygenation in ulcers and enhancing of cell proliferation, differentiation and accelerating of connective tissue maturation and healing of ulcers were demonstrated. In clinical studies the advantages of combination of standard antiulcer therapy and local endoscopic injection of platelet-rich plasma compared to only conservative therapy were shown.
Subject(s)
Intercellular Signaling Peptides and Proteins/therapeutic use , Mesenchymal Stem Cell Transplantation , Minimally Invasive Surgical Procedures/methods , Platelet-Rich Plasma/physiology , Stomach Ulcer/surgery , Stomach Ulcer/therapy , Adult , Aged , Animals , Cell Differentiation/drug effects , Cell Proliferation/drug effects , Chronic Disease , Disease Models, Animal , Female , Fibroblasts/cytology , Fibroblasts/drug effects , Humans , Male , Mesenchymal Stem Cells/cytology , Mesenchymal Stem Cells/physiology , Middle Aged , Platelet-Rich Plasma/chemistry , Rats , Rats, Wistar , Stomach Ulcer/pathology , Transplantation, AutologousABSTRACT
Antimicrobial properties of a composite based on decamethoxine and modified polysaccharides (carboxymethylamylum, oxyethyl-cellulose) were studied. The composite was shown to have high antimicrobial activity against grampositive and gramnegative bacteria under different conditions of the experiment.
