[Experimental rationale for the use of intra-arterial lymphostimulation in drug treatment of inflammatory diseases of organs of the peritoneal cavity]. / Eksperimental'noe obosnovanie primeneniia vnutriarterial'noi limfostimuliatsii v medikamentoznom lechenii vospalitel'nykh zabolevanii organov briushnoi polosti.

The functional status of regional lymph drainage was studied in 40 rats with various models of pyoinflammatory abdominal diseases. It was shown that intratissue lymphopoiesis and lymph drainage were suppressed in general fecal peritonitis and hemorrhagic pancreonecrosis, which was evident in 1.59-3.15-fold elimination time of the lymphotropic indicator indigo carmine from the tissue and organ depot of the abdomen. The intravenous lymphostimulation with 10% rheomacrodex solution led to 1.06-1.51-fold increases in lymphopoiesis and lymph drainage. Regional intraaortic lymphogenic stimulation caused the most marked changes in the lymph circulatory bed, producing 1.22-1.56-fold effects on lymph drainage of abdominal organs and tissue.

[Pharmacokinetic validation of intra-arterial lymphotropic antibiotic therapy of pyo-inflammatory diseases of organs of the peritoneal cavity]. / Farmakokineticheskoe obosnovanie vnutriarterial'noi limfotropnoi antibiotikoterapii gnoino-vospalitel'nykh zabolevanii organov briushnoi polosti.

Intraarterial infusion of antibiotics provided a 1.39-2.84-fold regional increase in the antibiotic concentration as compared to that after the intravenous infusion in the organs and tissues of the abdominal cavity affected by an inflammatory process. Regional intraarterial lymphostimulation provided a 1.31-1.64-fold increase in the antibiotic resorption from the affected organs and tissues of the abdominal cavity to the relevant regional lymph nodes. Combined intraarterial administration of the antibiotic and lymphostimulant made it possible to provide high antibiotic concentrations in both the affected organs and tissues of the abdominal cavity and the respective portions of the regional lymphatic system.

[Potential uses of plasma scalpel in liver and gallbladder surgery]. / Vozmozhnosti plazmennogo skalpelia pri operatsiiakh na pecheni i zhelchnom puzyre.

The article deals with the results of experimental studies and clinical experience in the use of the plasma scalpel in 25 unbred dogs and 192 patients with diseases of the liver and gallbladder. Histological studies of the hepatic tissue after treatment with the laser scalpel allowed the conclusion that such manipulations are safe. The advantages of using the device for arresting bleeding and the flow of bile from the resected hepatic areas were revealed. The accumulated experience in operations on the liver and gallbladder with a plasma scalpel made it possible to develop optimal approaches to the use of the plasma flow in resections of the liver and to suggest three methods for removal of the gallbladder. Their introduction into practice improved the intraoperative possibilities of treatment of the gallbladder bed.

[Morphological changes in patent ductus arteriosus after endovascular occlusion (clinico-experimental study)]. / Morfologicheskie izmeneniia v otkrytom arterial'nom protoke posle endovaskuliarnoi okkliuzii (kliniko-éksperimental'noe issledovanie).

The work is based on a comparison of data gained in experiments with the results of clinical examination of a large group of patients in the late-term period after endovascular occlusion of a patent ductus arteriosus (PDA). The regular features of the course of the morphological process in the zone of the PDA after implantation of a botallo-occluder into it were studied. Clinico-morphological parallels were made. The high efficacy and reliability of the new method of endovascular treatment of PDA, developed at the Moscow Second Medical institute, was substantiated morphologically and confirmed clinically.

[Magnetic-laser irradiation of the liver in the treatment and prevention of hepatic insufficiency in mechanical jaundice]. / Magnitolazernoe obluchenie pecheni pri lechenii i profilaktike pechenochnoi nedostatochnosti pri mekahnicheskoi zheltukhe.

The effect of magnetolaser irradiation on the liver in obstructive jaundice was studied in experiments on 500 rats. Magnetolaser irradiation was found to have a favourable effect on the functional morphology of the liver; it levels many morphological signs of hepatic insufficiency and thus provides the grounds for carrying out an operation on the bile ducts under optimal conditions. The suggested method of magnetolaser therapy was applied in 142 patients with hepatic insufficiency in obstructive jaundice. The study showed that magnetolaser therapy applied in complex treatment of hepatic insufficiency promotes active restoration of the function of the organ, significantly raises the efficacy of treatment, and reduces the term of the patient's hospital stay.

[Features of hematological changes after resection of the liver using a plasma scalpel]. / O nekotorykh osobennostiakh gematologicheskikh sdvigov pri operatsii rezektsii pecheni s primeneniem plazmennogo skal'pelia.

The resection of liver was undertaken in two series of experiments in rabbits with plasma and steel scalpels for comparison. After the interventions the haematological changes of stress nature were observed in animals. The changes of leucocytic and erythrocytic pictures and myelograms were more important and steady when the resections was made with plasma scalpel. The mentioned peculiarities must be taken into consideration in analysis of laboratory examinations in the clinic.

[Antimicrobial effect of irradiation with ionized plasma]. / Antimikrobnyi éffekt izlucheniia ionizirovannoi plazmy.

Ion plasma light flux has been found to possess bacteriostatic effect in vitro and in vivo. Three-fold irradiation with ion plasma of a wound infected by a pathogenic Staphylococcus aureus strain reduced phase I of wound healing by three days and the overall time of healing by four-five days.

[Experimental evaluation of the use of elastomer threads in vascular surgery]. / Eksperimental'naia otsenka primeneniia élastomernykh nitei v sosudistoi khirurgii.

Experiments were conducted for comparative analysis of the use of elastic (Spandex) and nonelastic (Eticon) threads for the formation of anastomoses in vascular surgery. The results were studied in follow-up periods of up to 18 months. Thrombosis occurred at the site of anastomosis only in 6.8% of cases in which elastic threads were applied in contrast to 30% of cases in which nonelastic threads were used. Microscopy in the first case revealed neither marked inflammatory reaction nor necroses, which promoted regeneration and the formation of the neointima. In the second case, on the one hand, the nonelastic anastomosis between two elastic tubes creates conditions for thrombus formation, and on the other, the tension occurring periodically in this zone causes damage to the tissues and prevents rapid formation of the neointima.

[Correction of metabolic disorders by magnetic-laser irradiation (experimental study)]. / Korrektsiia metabolicheskikh narushenii magnitolazernym oblucheniem (éksperimental'noe issledovanie).

Five series of experiments were conducted on a model of hepatic insufficiency caused by obstructive jaundice to study the effect of semiconductor infrared laser in a range of 800-900 nm with a static magnetic field on some metabolic changes in the organism. Wistar rats weighing 200-250 g were used. The region of the liver was irradiated through an intact epilated skin. The results provide evidence that a definite role in the pathogenesis of hepatic insufficiency is played by intensification of LPO processes and diminution of antioxidant defence which leads, in turn, to reduction of the insulin-receptor interrelations and sharp decrease of hepatic cell metabolism.

[Mutagenic effects of ionized plasma light flux]. / Issledovanie mutagennogo deistviia svetovogo potoka ionizirovannoi plazmy.

The effect of ion plasma light flux on the genomes of auxotrophic Escherichia coli strain and Drosophilla melanogaster has been examined. Essentially no mutagenic effect was found in doses close to therapeutic ones.

[Plasma scalpel in pulmonary surgery]. / Plazmennyi skal'pel' v khirurgii legkikh.

The "Plasma scalpel CP-M" device was used in experiments on dogs to study the possibility of applying plasma irradiation in the surgery of the lungs. The morphology of their "plasma wound" and reparative processes was studied. The plasma device was employed in the clinic in 40 various operations on the lungs and thoracic wall for cleansing the pleural cavity and operative wound, hemostasis from the walls of the pleural cavity, and hermetic closure of the lung wound surface. It was established that the plasma scalpel can be used effectively in hermetic closure of defects in the pulmonary tissue and cleansing of the pleural cavity and operative wound; for arresting diffuse bleeding from the walls of the pleural cavity, the plasma scalpel may be used only in combination with other methods of hemostasis.

[Treatment of experimental pancreonecrosis by occlusion of the pancreatic ducts and cryodestruction of necrotic foci]. / Lechenie éksperimenta'lnogo pancreonekroza okkliuziei pankreaticheskikh protokov i kriodestruktsii ochagov nekroza.

Experimental investigations (experiments in 61 dogs) have shown the application of drug occlusion on the gland duct system with cryodestruction of necrosis foci to be a promising method for treatment of pancreonecrosis.

[The possibility of correcting metabolic disorders in experimental liver cirrhosis by cryodestruction and plasma-flow resection]. / Vozmozhnost' korrektsii metabolicheskikh narushenii pri éksperimental'nom tsirroze pecheni metodom kriodestruktsii i rezektsi plazmennym potokom.

The first week after the cryodestruction, the resection of plasma flow and combined effect of the two methods causes metabolic changes, which later according to observations are normalized. The metabolic disturbances, which are connected with experimental liver cirrhosis under the combined cryodestructive effect and plasma flow resection are normalized three weeks after treatment. But there is no elimination of defects of free radical oxidation and there remains a decreased insulin binding capability of lymphocytes. All these processes should be taken into account in surgical treatment of liver cirrhosis.

[Accumulation of gentamicin in biological fluids, organs and tissues during regional lymphotropic therapy with antibiotics]. / Nakoplenie gentamitsina v biologicheskikh zhidkostiakh, organakh i tkaniakh pri limfotropnoi regionarnoi antibiotikoterapii.

Gentamicin distribution in biological fluids, organs and tissues, lymph nodes was studied on 70 dogs. Three administration routes were compared: lymphotropic, intramuscular and regional subcutaneous. The lymphotropic route for the drug administration was recommended not long ago. It was shown that the lymphotropic route provided the antibiotic accumulation mainly in some of the abdominal organs as compared to intramuscular administration. Regional lymphotropic administration of the antibiotic to the experimental animals resulted in higher gentamicin levels in the regional lymph nodes and regional organs as compared to the levels observed after the antibiotic regional subcutaneous administration in the same doses.

[The effect on the liver of a semiconductor IR laser with a constant magnetic field]. / Izuchenie vliianiia na pechen' poluprovodnikovogo IK-lazera s postoiannym magnitnym polem.

Comparative appraisal of the effect of repeated percutaneous action of semiconductor IR-laser, magnetic field, and a combination of these two factors on the liver showed metabolic changes to be sharply manifest in the first 10 days after exposure to the different variants of action. After 20 irradiation sessions the metabolic changes were less manifest and became stabilized in subsequent irradiation of the animals, which may probably be attributed to certain adaptation of the hepatic tissue to the prolonged effect of the factor. The distinguishing feature of the magnetic-laser effect was an increase of the main substrates of energy metabolism (glucose and lipids) and a stable malonic dialdehyde content with a predominant tendency towards neutralization of free-radical reactions. All this justifies the experimental substantiation of the necessity of using a semiconductor IR-laser with a constant magnetic field for correcting metabolic disorders associated with hepatic insufficiency.

[Modeling of acute pancreatitis]. / Modelirovanie ostrogo pankreatita.

The experience with modelling acute pancreatitis (AP) in dogs is summarized. In 15 of them, to reproduce AP, the intraductal administration of a bile with trypsin mixture was used, in 8--intraductal administration of automobile under the pressure, in 15--intraparenchymatous administration of automobile at several points. Depending on the method of modelling, the forms, rate and severity of the AP course were different.

[Use of dibunol and delagil in the treatment of acute pancreatitis]. / Primenenie dibunola i delagila v lechenii ostrogo pankreatita.

The effect of Dibunol and Delagil on the course of experimental pancreatitis was studied in experiments in 80 rats and 36 dogs. The intravenous injection of the drugs was shown to decrease lethality of the animals. Control of biochemical parameters has revealed decreased activity of amylase, lipase, trypsin and malonic dialdehyde, normalized level of superlight luminescence of blood plasma. A good medical effect was obtained in 15 patients with acute pancreatitis.