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1.
Avian Dis ; 51(1 Suppl): 269-72, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17494564

ABSTRACT

The H5N1 virus currently circulating is continuing to evolve, and it has already resulted in the extension of its host and geographical range. It is likely that H5N1 will become a global problem for the poultry industry. How many of the recent H5N1 changes observed have been induced by changing patterns in poultry raising? A change in attitude on the use of high-quality vaccines is a change that would drastically help in the control of the current epidemic in the poultry industry. This article provides an overview of the changing properties that have been observed during the current H5N1 outbreaks.


Subject(s)
Birds/virology , Influenza A Virus, H5N1 Subtype/pathogenicity , Influenza in Birds/epidemiology , Influenza in Birds/virology , Influenza, Human/virology , Animals , Humans , Influenza, Human/transmission , Virulence
2.
J Virol ; 79(17): 11269-79, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16103179

ABSTRACT

Wild waterfowl are the natural reservoir of all influenza A viruses, and these viruses are usually nonpathogenic in these birds. However, since late 2002, H5N1 outbreaks in Asia have resulted in mortality among waterfowl in recreational parks, domestic flocks, and wild migratory birds. The evolutionary stasis between influenza virus and its natural host may have been disrupted, prompting us to ask whether waterfowl are resistant to H5N1 influenza virus disease and whether they can still act as a reservoir for these viruses. To better understand the biology of H5N1 viruses in ducks and attempt to answer this question, we inoculated juvenile mallards with 23 different H5N1 influenza viruses isolated in Asia between 2003 and 2004. All virus isolates replicated efficiently in inoculated ducks, and 22 were transmitted to susceptible contacts. Viruses replicated to higher levels in the trachea than in the cloaca of both inoculated and contact birds, suggesting that the digestive tract is not the main site of H5N1 influenza virus replication in ducks and that the fecal-oral route may no longer be the main transmission path. The virus isolates' pathogenicities varied from completely nonpathogenic to highly lethal and were positively correlated with tracheal virus titers. Nevertheless, the eight virus isolates that were nonpathogenic in ducks replicated and transmitted efficiently to naïve contacts, suggesting that highly pathogenic H5N1 viruses causing minimal signs of disease in ducks can propagate silently and efficiently among domestic and wild ducks in Asia and that they represent a serious threat to human and veterinary public health.


Subject(s)
Influenza A Virus, H5N1 Subtype , Influenza A virus , Influenza, Human/virology , Animals , Asia , Carrier State , Cloaca/virology , Disease Models, Animal , Disease Transmission, Infectious , Ducks , Humans , Influenza A virus/pathogenicity , Influenza, Human/transmission , Trachea/virology , Virulence
3.
Proc Natl Acad Sci U S A ; 102(30): 10682-7, 2005 Jul 26.
Article in English | MEDLINE | ID: mdl-16030144

ABSTRACT

Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the "Trojan horse" of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat.


Subject(s)
Biological Evolution , Ducks/virology , Influenza A Virus, H5N1 Subtype/pathogenicity , Influenza in Birds/transmission , Animals , Asia , Hemagglutination Inhibition Tests/veterinary , Influenza A Virus, H5N1 Subtype/genetics , Influenza in Birds/virology , Neutralization Tests/veterinary , Sequence Analysis, DNA/veterinary , Time Factors , Virulence , Virus Shedding/immunology
4.
Proc Natl Acad Sci U S A ; 101(21): 8156-61, 2004 May 25.
Article in English | MEDLINE | ID: mdl-15148370

ABSTRACT

Infection with avian influenza A virus of the H5N1 subtype (isolates A/HK/212/03 and A/HK/213/03) was fatal to one of two members of a family in southern China in 2003. This incident was preceded by lethal outbreaks of H5N1 influenza in waterfowl, which are the natural hosts of these viruses and, therefore, normally have asymptomatic infection. The hemagglutinin genes of the A/HK/212/03-like viruses isolated from humans and waterfowl share the lineage of the H5N1 viruses that caused the first known cases of human disease in Hong Kong in 1997, but their internal protein genes originated elsewhere. The hemagglutinin of the recent human isolates has undergone significant antigenic drift. Like the 1997 human H5N1 isolates, the 2003 human H5N1 isolates induced the overproduction of proinflammatory cytokines by primary human macrophages in vitro, whereas the precursor H5N1 viruses and other H5N1 reassortants isolated in 2001 did not. The acquisition by the viruses of characteristics that enhance virulence in humans and waterfowl and their potential for wider distribution by infected migrating birds are causes for renewed pandemic concern.


Subject(s)
Influenza, Human/epidemiology , Influenza, Human/virology , Animals , Birds/virology , Cytokines/biosynthesis , Cytokines/immunology , Hemagglutination Inhibition Tests , Hong Kong , Humans , Inflammation Mediators/immunology , Influenza A Virus, H5N1 Subtype , Influenza A virus/classification , Influenza A virus/genetics , Influenza A virus/immunology , Influenza A virus/pathogenicity , Influenza, Human/transmission , Influenza, Human/veterinary , Macrophages/immunology , Macrophages/metabolism , Mice , Molecular Sequence Data , Organ Specificity , Phylogeny , Reassortant Viruses/immunology , Reassortant Viruses/pathogenicity , Time Factors , Virulence
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