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Peptides ; 28(2): 269-80, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17194505

ABSTRACT

We have utilized a rat model of peripheral artery disease (PAD) to examine whether the known angiogenic activity of the Y(2) receptor would translate into a meaningful increase in collateral blood flow. The maximal increase in collateral blood flow capacity of approximately 60% (p<0.001) was obtained with a 10microg/kgday (IA infusion, 14 days) of either PYY or PYY(3-36) and did not differ from that obtained with a maximally angiogenic dose of VEGF(165). Pharmacodynamic modeling based upon single dose pharmacokinetic plasma profiles of both agonists suggests that E(max) is reached when the Y(2) receptor is occupied by >or=50%. Furthermore, for PYY(3-36), occupancy of the Y(2) receptor is sufficient to promote a significant benefit in collateral blood flow.


Subject(s)
Blood Circulation/physiology , Models, Biological , Peripheral Vascular Diseases/metabolism , Receptors, Neuropeptide Y/physiology , Animals , Base Sequence , DNA Primers , Female , Humans , Rats , Rats, Sprague-Dawley , Reverse Transcriptase Polymerase Chain Reaction
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