ABSTRACT
OBJECTIVE: This study focused on investigating the relationship between the level of regulatory T cells (Tregs) infiltration and the prognosis of pancreatic cancer patients by using meta-analysis to identify new clinical diagnostic markers. MATERIALS AND METHODS: We looked through PubMed, Embase, and the Cochrane Library for studies published between the database's inception and September 2021. We included studies that looked at the relationship between Tregs and pancreatic cancer prognosis. We exempted duplicate publications, studies without full text, insufficient information, or inability to conduct data extraction, animal experiments, reviews, and systematic reviews. The data were analyzed using STATA 15.1. RESULTS: The pooled results show that high infiltrating Treg is highly correlated with lower OS of pancreatic cancer patients (HR=1.56, 95% CI: 1.23-1.990.000), but not with DFS of patients with pancreatic cancer (HR=1.29, 95% CI: 0.88-1.89, p=0.184). On the other hand, the results show that high infiltrating Treg is significantly associated with lower OS (HR=2.13, 95% CI: 1.70-2.67, p=0.000) and DFS (HR=1.79, 95% CI: 1.12-2.86, p=0.015) in patients from Asia, whereas it is not significantly associated with OS and DFS in patients from Europe and America. CONCLUSIONS: This meta-analysis suggests that the assessment of Tregs may help to predict the prognosis in pancreatic cancer patients. Advanced histological techniques for obtaining more detailed information about Treg activity may assist in the identification of novel treatment strategies.
Subject(s)
Lymphocytes, Tumor-Infiltrating , Pancreatic Neoplasms , Humans , Lymphocyte Count , Pancreatic Neoplasms/diagnosis , Prognosis , T-Lymphocytes, Regulatory , Pancreatic NeoplasmsABSTRACT
All jumping spiders have unique, complex eyes with exceptional spatial acuity and some of the most elaborate vision-guided predatory strategies ever documented for any animal of their size. However, it is only recently that phylogenetic techniques have been used to reconstruct the relationships and key evolutionary events within the Salticidae. Here, we used data for 35 species and six genes (4.8 kb) for reconstructing the phylogenetic relationships between Spartaeinae, Lyssomaninae and Salticoida. We document a remarkable case of morphological convergence of eye ultrastructure in two clades with divergent predatory behaviour. We, furthermore, find evidence for a stepwise, gradual evolution of a complex predatory strategy. Divergent predatory behaviour ranges from cursorial hunting to building prey-catching webs and araneophagy with web invasion and aggressive mimicry. Web invasion and aggressive mimicry evolved once from an ancestral spartaeine that was already araneophagic and had no difficulty entering webs due to glue immunity. Web invasion and aggressive mimicry was lost once, in Paracyrba, which has replaced one highly specialized predation strategy with another (hunting mosquitoes). In contrast to the evolution of divergent behaviour, eyes with similarly high spatial acuity and ultrastructural design evolved convergently in the Salticoida and in Portia.
