Subject(s)
Azathioprine/adverse effects , Immunosuppressive Agents/adverse effects , Methyltransferases/genetics , Polymorphism, Genetic/genetics , Pyrophosphatases/genetics , Rheumatic Diseases/genetics , Rheumatic Diseases/metabolism , Adolescent , Adult , Asian People , Humans , Middle Aged , Mutation/genetics , Young AdultABSTRACT
OBJECTIVE: It has been shown previously that the IL-23 receptor (IL-23R) variants are associated with ankylosing spondylitis (AS). It is unknown whether IL-23R is associated with AS in the Chinese population. The present study was performed to examine the association of IL-23R gene polymorphisms with susceptibility to AS in the Chinese population. METHODS: A total of 157 Chinese Han patients with AS and 150 ethnically matched healthy controls were enrolled. All patients were diagnosed with AS according to the modified New York criteria. 8 single nucleotide polymorphisms (SNPs) of the IL-23R gene cluster were genotyped. RESULTS: None of the 8 IL-23R SNPs were found to be associated with AS in the Chinese population. CONCLUSION: The association of IL-23R and AS that is seen in Caucasian patients with AS is not present in Chinese patients with AS.
