Subject(s)
Humans , Male , Middle Aged , Melanoma , Esophageal Neoplasms , Hematemesis , Gastric Fundus/pathology , Gastric Fundus , Esophagus/pathology , Esophagus , Endoscopy , Endoscopy, Digestive System/instrumentation , Endoscopy, Digestive System/methods , Endoscopy, Digestive System , Thorax/pathology , Thorax , Abdomen , PelvisABSTRACT
Pegylated interferon and ribavirin is the treatment of choice in patients with chronic hepatitis C infection. The most common side effects of interferon therapy are flu-like symptoms and psychiatric disorders. Pneumonitis is a less frequent complication associated with non-negligible mortality. We herein report a case of interferon associated pneumonitis in a patient with non-severe clinical symptoms and a normal chest radiography. Physicians should be aware of this entity during the differential diagnosis of respiratory symptoms in patients receiving treatment with interferon due to its high morbimortality and good resolution and outcome after drug withdrawal.
Subject(s)
Antiviral Agents/adverse effects , Hepatitis C/complications , Interferon-alpha/adverse effects , Lung Diseases, Interstitial/chemically induced , Polyethylene Glycols/adverse effects , Antiviral Agents/therapeutic use , Hepatitis C/drug therapy , Humans , Interferon alpha-2 , Interferon-alpha/therapeutic use , Lung Diseases, Interstitial/complications , Lung Diseases, Interstitial/diagnostic imaging , Male , Middle Aged , Polyethylene Glycols/therapeutic use , Recombinant Proteins , Tomography, X-Ray ComputedABSTRACT
El interferón pegilado asociado a ribavirina es el tratamiento de elección en los pacientes con infección por hepatitis C crónica. Los efectos secundarios más comunes son los síntomas gripales y las alteraciones psiquiátricas. La neumonitis es una complicación poco frecuente, pero se asocia con una mortalidad no despreciable. Presentamos el caso clínico de un paciente con neumonitis intersticial asociada a interferón que presentaba signos y síntomas clínicos sutiles y una radiografía de tórax sin alteraciones. Se debe de tener presente esta entidad en el diagnóstico diferencial de los síntomas respiratorios en pacientes que reciben tratamiento con interferón debido a su elevada morbi-mortalidad y a su evolución favorable tras la retirada del fármaco(AU)
Pegylated interferon and ribavirin is the treatment of choice in patients with chronic hepatitis C infection. The most common side effects of interferon therapy are flu-like symptoms and psychiatric disorders. Pneumonitis is a less frequent complication associated with non-negligible mortality. We herein report a case of interferon associated pneumonitis in a patient with non-severe clinical symptoms and a normal chest radiography. Physicians should be aware of this entity during the differential diagnosis of respiratory symptoms in patients receiving treatment with interferon due to its high morbimortality and good resolution and outcome after drug withdrawal(AU)
Subject(s)
Humans , Male , Middle Aged , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/therapy , Interferons/therapeutic use , Ribavirin/therapeutic use , Hepatitis C, Chronic/diagnosis , Hepatitis C, Chronic/drug therapy , Bronchoalveolar Lavage/methods , Bronchoalveolar Lavage , Lung Diseases, Interstitial/physiopathology , Diagnosis, Differential , Radiography, Thoracic , Indicators of Morbidity and Mortality , Dyspnea/complications , Heart RateABSTRACT
Sarcomas of the kidney are exceedingly uncommon. They represent between 1 and 3% of all malignant renal tumors. Several histological types have been reported. We have reviewed the renal tumors diagnosed in our department in the last 25 years and found 4 cases of sarcoma out of 390 malignant renal tumors (1.02%). They were a liposarcoma, a storiform-pleomorphic fibrous malignant histiocytoma, a rhabdomyosarcoma and a pleomorphic leiomyosarcoma. We report the clinical data and the outcome of the patients, together with the immunohistochemical and ultrastructural findings in these cases.
