ABSTRACT
We report the first published case of integrase inhibitor resistance in the central nervous system compartment in the absence of evidence of integrase inhibitor resistance in the plasma of a patient without human immunodeficiency virus (HIV)-encephalitis in the context of other HIV-associated central nervous system infections.
Subject(s)
AIDS Dementia Complex/virology , Anti-HIV Agents/pharmacology , Cerebrospinal Fluid/virology , Drug Resistance, Viral , HIV/drug effects , Pyrrolidinones/pharmacology , AIDS Dementia Complex/drug therapy , Anti-HIV Agents/administration & dosage , Brain/diagnostic imaging , HIV/isolation & purification , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Plasma/virology , Pyrrolidinones/administration & dosage , Radiography , Raltegravir PotassiumABSTRACT
BACKGROUND/AIM: IgG4-related systemic disease (IgG4-RSD) is a systemic inflammatory disease distinguished by tissue infiltrates of IgG4(+) plasma cells and elevated serum IgG4 levels. While IgG4-RSD often involves the pancreas, extra-pancreatic organs are also frequently affected. Here, we review the presentation and management of patients with extra-pancreatic IgG4-RSD. METHODS: A retrospective analysis was performed on patients diagnosed with extra-pancreatic IgG4-RSD identified from a single centre. RESULTS: Six patients with extra-pancreatic IgG4-RSD were identified. The median age of the patients was 64 years. The range of involved organs included lymph nodes (three patients), ocular adnexa, lung, kidneys, meninges and exocrine glands. The median delay in diagnosis was 13.5 months (4-60 months). Four patients had elevated serum IgG4 levels at diagnosis. Five symptomatic patients were commenced on combination immunosuppression, which included corticosteroids. Maintenance therapy with azathioprine was used in one patient, methotrexate and mycophenolate were each used in two patients, and cyclophosphamide in one patient. Four treated patients went into remission, while two patients had persistent radiological disease. One patient experienced two relapses. CONCLUSION: IgG4-RSD can manifest in a variety of organs. Lack of awareness regarding this entity may delay diagnosis. Combination treatment of corticosteroids and conventional immunosuppression is effective.
Subject(s)
Autoimmune Diseases/blood , Autoimmune Diseases/drug therapy , Immunoglobulin G/blood , Immunosuppression Therapy/methods , Immunosuppressive Agents/administration & dosage , Pancreatic Diseases , Aged , Autoimmune Diseases/diagnosis , Azathioprine/administration & dosage , Biomarkers/blood , Drug Therapy, Combination , Female , Follow-Up Studies , Humans , Inflammation/blood , Inflammation/diagnosis , Inflammation/drug therapy , Male , Middle Aged , Pancreatic Diseases/blood , Pancreatic Diseases/immunology , Retrospective Studies , Treatment OutcomeSubject(s)
Amyloid Neuropathies, Familial/diagnosis , Amyloid/chemistry , Mutation, Missense , Point Mutation , Prealbumin/analysis , Vision Disorders/diagnosis , Vitreous Body/chemistry , Amino Acid Substitution , Amyloid Neuropathies, Familial/complications , Amyloid Neuropathies, Familial/genetics , Amyloid Neuropathies, Familial/surgery , Humans , Male , Middle Aged , Phenotype , Prealbumin/genetics , Sequence Analysis, DNA , Vision Disorders/etiology , Vision Disorders/surgery , Visual Acuity , Vitrectomy , Vitreous Body/surgeryABSTRACT
BACKGROUND: Estimates of the prevalence of paraproteinaemia vary, from 1% in persons aged over 25 years to 10% in those aged over 80 years, although there are limited data from well-defined populations. We sought to determine the prevalence of paraproteinaemia in Australians aged 50 years and over, and to determine risks factors for its presence. METHODS: We performed a population-based, cross-sectional study using data and serum collected in the Blue Mountains Eye Study. Serum samples from 2933 patients were analysed by capillary zone electrophoresis and, where indicated, immunosubtraction, which allowed for both quantitation and isotype detection. RESULTS: A paraprotein was detected in 134 of the 2933 samples, giving an overall prevalence of 4.6% (95% confidence interval, 3.8-5.3%). The presence of a paraprotein was strongly age-related (P(trend) = 0.001), with a prevalence of 2.8% in persons aged 50-59 years, rising steadily to 9.1% in those aged 80 years and over. The prevalence was significantly higher in men (5.9%) compared with women (4.0%) (P= 0.03). CONCLUSION: We conclude that approximately one in 20 Australians aged 50 years or over harbours a paraprotein, a prevalence that appears higher than from similar cohorts in other countries.
