Ancestry analysis using autosomal SNPs in northern South America, reveals interpretation differences between an AIM panel and an identification panel.

Current human populations are studied to elucidate their ancestry composition and to obtain reference values for an array of genetic markers for forensic practice. This study compared the 79 ancestry informative markers (AIMs) panel with the SNPforID 52plex set used in forensic identification, using samples belonging to Continental Caribbean populations from Colombia with a high percentage of locals self-determined as Native American descendants. The results show a bias in the individual estimation made with the identification markers, which disregards the Native American ancestry component and overestimates the African ancestry component. Also, the analysis made with the Bayesian Classification Algorithm shows better likelihoods for individual assignment with AIMs than with SNPforID 52plex.

Actividad física cotidiana y estado de salud en pacientes recuperados de infarto miocárdico / Daily physical activity and health condition in patients recovering from myocardial infarction

Fundamento: La mayoría de los expertos coinciden en afirmar que el entrenamiento físico constituye la piedra angular en la rehabilitación cardiovascular. Este puede ser más beneficioso que el control adecuado de los factores de riesgos coronarios. Objetivo: Determinar la repercusión del consumo energético calórico por concepto de actividad física cotidiana, sobre la forma física y el estado de salud en pacientes recuperados de infarto miocárdico. Métodos: Se realizó un estudio, comparativo, con 147 pacientes recuperados de un infarto miocárdico agudo de bajo riesgo, los cuales se agruparon en tres grupos. Todos los pacientes fueron del sexo masculino y menores de 61 años, (media 54 ± 6.0), asistidos en el Hospital Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en los cuales no se llevó a cabo rehabilitación cardiovascular. Resultados: Los individuos que generalmente realizaron una actividad física ordinaria con gasto calórico energético mayor a 150 kilocalorías diarias, mostraron, durante la prueba ergométrica, estar en mejor forma física que los pacientes que gastaron menos de 150 Kilocalorías diarias en sus actividades ordinarias. Pero en la medida en que fueron superadas las 300 kilocalorías/día a pesar de estar en mucha mejor forma física, también se incrementó la sintomatología propia del riesgo cardiovascular. Conclusiones: El simple hecho de realizar actividades ordinarias tan comunes como caminar, que impliquen un gasto calórico energético promedio entre 150 a 300 kilocalorías diarias, puede ser beneficioso para pacientes infartados de bajo riesgo que no han recibido rehabilitación cardiovascular; ello influye también en la forma física, y disminuye las probabilidades de aparición de efectos adverso(AU)

Background: Most experts agree that physical training is the cornerstone of cardiac rehabilitation. It might be even more beneficial than appropriate control of coronary risk factors. Objective: To determine the impact of energy caloric expenditure caused by daily physical activity on fitness and health condition of patients recovering from myocardial infarction. Methods:A comparative study with 147 patients recovered from acute, low-risk myocardial infarction, which were grouped into three groups . Patients were all males, less than 61 years old (mean 54 ± 6.0) who had received medical attention at the University Hospital Dr. Gustavo Aldereguía Lima of Cienfuegos. Cardiac rehabilitation had not been carried out. Results: Individuals who typically engage in regular physical activity with energy expenditure over 150 calories a day showed, in their ergometer test, to be in better shape than those who spend less than 150 kilocalories a day. Nevertheless, as calories expenditure exceeded 300 kcal / day physical shape was much better but characteristic symptoms of cardiovascular risk increased. Conclusions: Simply by carrying out common ordinary activities such as walking, with energy caloric expenditure from 150 to 300 calories a day, may be beneficial for low-risk, post-infarct patients who did not receive cardiac rehabilitation. It also influences physical shape and decreases the probabilities of adverse effects emergence(AU)

Analysis of the CODIS autosomal STR loci in four main Colombian regions.

Genotype polymorphism studies at the 13 loci STRs included in the combined DNA index system [CODIS and PCR-based short tandem repeat loci, in: Proceedings of the Second European Symposium on Human Identification, Promega Corporation, Madison, WI, 1998, pp. 73-88; J. Forensic Sci. 46 (2001) 453] (CODIS: D3S1358, HUMvWA31, HUMFGA, D8S1179 D21S11, D18S51, D5S818, D13S317, D7S820, HUMTH01, HUMTPOX, HUMCSF1PO and D16S539) were carried out in a sample of 1429 unrelated Colombian individuals belonging to 25 different departments. As many other countries in Latino-America, Colombia shows an important admixture component, basically integrated by Amerindians, European-descendants and African-descendants. Due to the fact that only partial population analyses have been carried out in the country, the main aim of the present analysis is to establish a database of forensic interest based on the widely used CODIS systems covering the main Colombian regions.