Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects.

Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis, usually self-limited and presenting with massive, painless, bilateral cervical lymphadenopathy, with or without constitutional symptoms. Extranodal disease is frequently present, and may happen in the absence of lymph node involvement, symptomatology and differential diagnosis will depend on the site affected and fatal cases may occur. The authors present two cases of Rosai-Dorfman disease (RDD), diagnosed through immunohistochemistry, with different progressions, one with complete remission and one culminating in death, highlighting the variety of presentations and the diagnostic difficulty. RDD is a rare condition with clinical presentations similar to several diseases, and should be considered in the differential diagnosis of lymphadenopathy with extranodal lesions.

Perspectivas sobre a morte em pacientes com doença renal crônica e seus cuidadores familiares: um olhar sobre a relação com a saúde mental e o suporte social / Perspectives on death in patients with chronic kidney disease and their family caregivers: a look at the relationship with mental health and social support

Introdução: A doença renal crônica (DRC) consiste em um contexto de diversas perdas para pacientes e cuidadores. Essa realidade corresponde a processos de elaboração de perdas e lutos com impactos sobre a saúde mental de ambos. Objetivo: Avaliar as perspectivas sobre a morte e correlacionar com aspectos de saúde mental e suporte social. Materiais e Métodos: Estudo transversal com 31 participantes, sendo 14 pacientes com doença renal crônica em diálise em um Hospital Universitário no interior de Minas Gerais, Brasil, e 17 familiares. Os instrumentos utilizados foram: questionário sociodemográfico e de saúde, o Questionário de Qualidade de Vida (SF-36); Escala Hospitalar de Ansiedade e Depressão (HADS), Escala de Percepção do Suporte Social (SPSS), Pictograma de Fadiga (PF), Inventário de Sintomas de Estresse de Lipp (ISSL) e Escalas Breves de Perspectivas Sobre Morte (EBPM). Para a análise estatística as variáveis foram descritas como média, desvio padrão, mediana ou frequência conforme sua característica. Foi realizada a correlação de Pearson ou Spearman, considerando p<0,05. O software estatístico SPSS 17.0. Resultados: Os pacientes eram 50% (n= 7) do sexo feminino com idade média de 54,71 (±15,96) anos e os cuidadores eram 70,58% (n= 12) do sexo feminino, com idade média de 50,82 (±14,88) anos. Na avaliação geral (n= 31), houve uma associação negativa do domínio físico do SF-36 com a perspectiva de "morte como coragem" (r= -0,37, p= 0,04), uma associação positiva dos sintomas de ansiedade (r= 0,36, p= 0,04) e de depressão (r= 0,46, p= 0,01) com a perspectiva de morte como "sofrimento e solidão" (EBPM-1). Nos pacientes (n= 14), houve uma associação negativa entre o suporte social prático e a EBPM-1 (r= -0,719, p= ,006). Nos cuidadores, houve uma associação positiva entre as fases do estresse e a EBPM-1 (r= 0,48, p= 0,05). Conclusão: As perspectivas sobre a morte se relacionam com aspectos de saúde mental e suporte social em pacientes com DRC e cuidadores.

Introduction: Chronic kidney disease (CKD) is a context of diverse losses for patients and caregivers. This reality corresponds to processes of processing losses and mourning with impacts on the mental health of both. Objective: To evaluate perspectives on death and correlate with aspects of mental health and social support. Materials and Methods: Cross-sectional study with 31 participants, 14 patients with chronic kidney disease undergoing dialysis at a University Hospital in Minas Gerais, Brazil, and 17 family members. The instruments used were: sociodemographic and health questionnaire, the Quality of Life Questionnaire (SF-36), Hospital Anxiety and Depression Scale (HADS), Perceived Social Support Scale (SPSS), Fatigue Pictogram (PF), Lipp Stress Symptom Inventory (ISSL) and Brief Perspectives on Death Scales (EBPM). For statistical analysis, variables were described as mean, standard deviation, median or frequency according to their characteristics. Pearson or Spearman correlation was performed, considering p<0.05. SPSS 17.0 statistical software. Results: Patients were 50% (n= 7) female with a mean age of 54.71 (±15.96) years and caregivers were 70.58% (n= 12) female, with a mean age of 50. 82 (±14.88) years. In the general assessment (n= 31), there was a negative association between the physical domain of the SF-36 and the perspective of "death as courage" (r= -0.37, p= 0.04), a positive association with symptoms of anxiety (r= 0.36, p= 0.04) and depression (r= 0.46, p= 0.01) with the prospect of death as "suffering and loneliness" (EBPM-1). In patients (n= 14), there was a negative association between practical social support and EBPM-1 (r= -0.719, p= .006). In caregivers there was a positive association between the phases of stress and EBPM-1 (r= 0.48, p= 0.05). Conclusion: Perspectives on death are related to aspects of mental health and social support in CKD patients and caregivers.

Association between fear of falling and a history of falls in patients with end-stage renal disease on hemodialysis.

INTRODUCTION: Hemodialysis patients have complications that increase fear of falling (FOF). This study evaluated the association between FOF and a retrospective history of falls in hemodialysis patients and investigated the ability of the Fall Efficacy Scale-International (FES-I) to discriminate fallers from nonfallers. METHODS: A retrospective study was conducted with 183 patients to investigate the history of falls in the last 12 months and to evaluate FOF by the FES-I. RESULTS: The univariate linear regression model showed that the FES-I score was significantly associated with a history of falls (p = 0.01). After adjustment for potential confounders, this association remained significant (R2  = 0.19, p < 0.001). The FES-I score showed an area under the curve of 0.660 with a cutoff point of 25 (sensitivity-61.8%; specificity-62.2%). CONCLUSION: FOF was associated with a history of falls in the 12-month period in hemodialysis patients, and FOF assessed by the FES-I was able to discriminate fallers from nonfallers.